Yazar "Bek, Sibel Gökçay" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    HEPCIDIN AND VITAMIN D LEVELS: MUTUAL EFFECTS IN ANEMIA OF CHRONIC KIDNEY DISEASE
    (2021) Ustuner, Berna; Bek, Sibel Gökçay; Eren, Necmi; Bakirdogen, Serkan; Kalender, Betül Gönüllü
    Objective: Hepcidin is a peptide with anti-microbial properties that is largely synthesized in the liver and has important roles in iron homeostasis,with serum levels elevated in chronic inflammatory conditions, including chronic kidney disease (CKD). Our aim was to discuss on the role ofvitamin D in regulation of hepcidin and anemia of CKD.Methods: The study group included 103 patients with CKD and 59 healthy individuals. The serum concentration of hepcidin was measured usingELISA, and the association to the following factors was evaluated: age, sex, body mass index, renal functions (estimated glomerular filtration rate,eGFR), drug history, serum biochemistry, complete blood count, iron and total iron binding capacity, ferritin, vitamin D, high sensitive C-reactiveprotein, C-reactive protein, and the erythrocyte sedimentation rate.Results: The mean age of the CKD group was 58.63 ± 11.8 years (with 16, 26, 27, 19, and 15 patients; respectively in each chronic kidney diseasestage, from I through V and nine on haemodialysis, six on peritoneal dialysis). The mean hepcidin concentration was higher in the chronic kidneydisease (30.3±24.7 ng/ml) than control (17.8 ± 8.4ng/ml) group (p<0.05). There was a positive association between hepcidin and CRP, ESR and thefollowing serum factors (urea, creatinine, ferritin, phosphate, pH, parathyroid hormone and alkaline phosphatase), with a negative association witheGFR, haemoglobin, haematocrit, calcium, magnesium, 25-OH vitamin D and bicarbonate levels.Conclusion: Hepcidin levels were found negatively correlated with 25-OH vitamin D levels which was related with the inflammatory effects ofvitamin D and hepcidin.
  • [ X ]
    Öğe
    The Effects of Peripheral Platelet and Leukocyte Counts on Platelet Agregation in Peritoneal Dialysis Patients
    (2018) Bakırdöğen, Serkan; Bek, Sibel Gökçay; Eren, Necmi; Uzay, Ant; Bilgili, Ümit; Çekmen, Mustafa Baki; Yavuz, Sara
    INTRODUCTION: Studies in healthy individuals andpatients with coronary artery disease have demonstratedthat circulating platelet and leukocyte counts affect plateletaggregation. The aim of our study was to investigatewhether there is such a relationship betweenleukocyte/platelet counts and platelet aggregation in endstagerenal disease patients on peritoneal dialysis (PD).METHODS: Forty-three PD patients were included in thestudy. Multiple electrode aggregometry method capable ofmeasuring platelet aggregation in whole blood was used.RESULTS: A statistically significant positive correlationbetween platelet aggregation and leukocyte and platelet countsin complete blood count (CBC) was seen. This positivecorrelation was stronger for platelets than leukocytes.DISCUSSION and CONCLUSION: Platelet and leukocytecounts in CBC in PD patients might be important on plateletaggregation. This might be another risk factor contributing toalready increased thrombosis risk in these patients.