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Öğe 4-YEAR-OLD CASE WAS ADMITTED TO HOSPITAL WITH DELIRIUM CAUSED BY DEHYDRATION AND METABOLIC ACIDOSIS(2023) Özcan, Eda Gül; Kaymaz, Nazan; Aylanç, Hakan; Şehitoğlu, M.Hilal; Kurtuluş, ŞenayDelirium, a potentially reversible, acute-onset organic brain syndrome, is a behavioral manifestation of acute brain dysfunction associated with underlying medical conditions. It presents as marked and inconsistent mental changes characterized by dysregulated states of focus and cognition. It can be caused by several different causes, including infections, drugs, toxins, metabolic disorders, and a number of other medical conditions. This case report presents a 4-year-old girl with short bowel syndrome, who developed hyperactive delirium due to acute metabolic acidosis.Öğe A case of IVIG-resistant Kawasaki disease with gallbladder hydrops(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2015) Yildirim, Şule; Binneto?lu, Fatih Köksal; Tekin, Mustafa; Battal, Fatih; Aylanç, Hakan; Aylanç, Nilüfer; Kaymaz, NazanKawasaki Disease is an acute systemic vasculitis of childhood affecting small and medium-sized arteries particularly coronary arteries. Intravenous immunoglobulin therapy decreases the major cardiovascular complication of the disease. Atypical clinical conditions may accompany to the disease and these cases seem to be more prone to intravenous immunoglobulin resistance which is an important problem in the management of the cases. Herein, we presented a case of 4-year-old boy admitted to our emergency department with fever of 5 days duration and diagnosed as Kawasaki disease based on the clinical, laboratory and imaging findings. He was resistant to intravenous immunoglobulin treatment and in the follow up resulting abdominal tenderness was explained by gallbladder hydrops. Copyright © 2015 by Türkiye Klinikleri.Öğe Ailesinde nodüler guatr olan çocukların tiroid lezyon prevalansı(Yusuf Haydar ERTEKİN, 2017) Aşık, Zuhal; Aylanç, HakanGiriş: Nodüler guatrın genetik olarak kümelenmesi ile ilgili yeterli çalışma yoktur. Her ne kadar ikiz çalışmaları genetik bir kümelenme göstermişse de, bu konuyla ilgili yapılmış prospektif bir çalışma yoktur. Bu çalışmanın amacı ailesinde nodüler guatrı olan çocuklardaki nodül prevelansının değerlendirilerek ailesel kümelenmenin varlığının araştırılmasıdır.Yöntem: Ailesinde nodüler guatr tespit edilen ve edilmeyen çocukların tiroit ultrasonu ile değerlendirilerek nodül prevelansı hesaplanmıştır.Bulgular: Tüm çocukların 5’inde (%3,4) nodüler guatr saptandı. Ailesinde nodüler guatr öyküsü olan çocukların 2’sinde (%2,5), kontrol grubundaki çocukların 3’ünde (%4,7) nodüler guatr tespit edildi. 2 grup arasında istatistiksel olarak anlamlı fark saptanmadı. Sonuç: Bu çalışma nodüler guatr hastalığının ailesel yönünü araştıran ilk prospektif çalışmadır. Çalışmamızda nodüler guatrlı hastaların çocuk kitlesi hedeflenmiştir. Yapılan istatistiksel analiz sonucunda MNG’lı hastaların çocuklarında nodüler guatrın kümelenmediği izlenmiştirÖğe Akut Gastroenteritli Çocuklarda Rotavirüs Sıklığı(Çanakkale Onsekiz Mart Üniversitesi, 2014) Tekin, Mustafa; Topaloğlu, Naci; Yıldırım, Şule; Binnetoğlu, Köksal; Kaymaz, Nazan; Aylanç, Hakan; Battal, Fatih; Vural, Ahmet; Başer, EsraViral gastroenteritlerin ve özellikle rotavirüse bağlı ishallerin epidemiyolojik ve klinik özelliklerinin takip edilmesi ve buna göre korunma ve tedavi stratejilerinin geliştirilmesi önemlidir. Bu nedenle biz de kliniğimize akut ishal nedeniyle başvuran olgularda rota virüs ishallerini araştırdık. 2011-2013 tarihleri arasında ÇOMÜ Tıp Fakültesi Hastanesi çocuk polikliniği ve acil servisine akut ishal nedeniyle baş vuran ve dışkı örnekleri incelenen 263 olgunun hastane kayıt verileri geriye dönük olarak tarandı. Dışkı örnekleri, kalitatif monoklonal antikorlarla kaplanmış kromatografik immunoassay yöntemi ile çalışan ticari bir test kiti (Rota-Adeno Virus Combo Test Device, Ecotest, Çin) ile incelenmişti. Toplam 263 akut ishalli olgu dosyası incelendi. Rota antijen pozitifliği bütün olguların 62’sinde (%23,6) saptandı. 2 yaş altı çocuklarda sıklık %34,5 olarak saptandı. Rota pozitifliğinin mevsimlere göre sıklığı sırasıyla ilkbaharda %27,8, yazın %14,6, sonbaharda %26,3 ve kışın %21,4 idi. Sonuç olarak akut ishalli olgu yönetimi yaşa ve mevsime göre yapılmalıdır. Bu tür ishalli olgularda gerekirse hızlı tanı testleri kullanılarak gereksiz antibiyotik kullanımından kaçınılmalıdır.Öğe Bronşta diş: Anamnez ve akciğer grafisinin önemi(2015) Battal, Fatih; Aylanç, Hakan; Bahadır, Gökhan Berktuğ; Tekin, Mustafa; Yıldırım, ŞuleÇocuklarda kronik öksürüğün nadir nedenlerinden birisi de bronşta yabancı cisim bulunmasıdır. Dokuz yaşında kız hasta, altı aydır süren öksürük şikayeti ile başvurdu. Anamnezde hastanın dişini yuttuğunu daha önce başvurduğu merkezlerde ifade etmesine rağmen astım ve pnömoni tanısı aldığı ve ilaçlarla şikayetlerinin geçmediği ve herhangi bir tetkik yapılmadığı öğrenildi. Fizik muayenesinde dinlemekle sağda ekspiryum uzunluğu olup sağ hemitoraksta dinlemekle solunum sesi azalmıştı. Kan tetkiklerine hafif lökositoz dışında özellik yoktu. Akciğer grafisinde sağ bronşial alanda opak görünümü mevcuttu. Hasta bu bulgularla solunum yolunda yabancı cisim tanısı aldı. Çocuk cerrahisine konsülte edildi ve bronkoskopi yapıldı. Sağ bronştan bir adet molar diş çıkartıldı. Öksürük şikayeti müdahale sonrasında gerileyen hastanın takiplerinde şikayeti tekrarlamadı. Olgu kronik öksürük şikayeti ile başvuran okul çağı çocuğunda anamnezin, fizik muayenenin ve akciğer grafisinin ne kadar önemli olduğunu vurgulamak amacıyla sunulmuştur.Öğe Bıçağın İki Yüzü: Kromozom 17p11.2 Delesyon ve Duplikasyon Sendromları(2021) Çokyaman, Turgay; Erdem, Ülgen Özcan; Aylanç, Hakan; Sılan, FatmaPotocki Lupski ve Smith Magenis sendromları insan 17. kromozom kısa kolu (11.2 bandı) ile ilişkili sendromlardır. Bu bölgenin duplikasyonu Potocki Lupski, delesyonu ise Simth Magenis sendromu olarak tanımlanmaktadır. Çocukluk çağında nadir görülen bu hastalıkların tipik fenotipik özellikleri olsa da tanı ileri genetik analizlerle konulmaktadır. Bu makalede nörolojik gelişimsel gerilik başta olmak üzere bu iki sendromun neden olduğu diğer nörolojik komplikasyonları belirtmeyi ve pediyatri klinisyenlerinin bu sendromlara dikkatini çekmeyi amaçladık. Potocki Lupski and Smith Magenis syndromes are associated with the human 17th chromosome short arm (11.2 band). Duplication of this region is defined as Potocki Lupski syndrome, and its deletion is defined as Smith Magenis syndrome. Although these diseases, which are rare in childhood, have typical phenotypic features, the diagnosis is made with advanced genetic analysis. In this article, we aimed to point out especially neurological developmental delay and other neurological complications caused by these two syndromes and draw the attention of pediatric clinicians to these syndromes.Öğe Central Anticholinergic Syndrome Following Excessive Mydriatic Use in an Eight-Year-Old Patient(Aydın Pediatric Society, 2021) Kaymaz, Nazan; Uzun, Mehmet Erdem; Battal, Fatih; Güzel, Yusuf; Aylanç, HakanCyclopentolate hydrochloride, belonging to a class of drugs known as anticholinergics, is an ophthalmic solution frequently used in ophthalmology clinics because of its cycloplegic and mydriatic effects in both refractions as well as fundus examinations. After application, the maximum cycloplegic effect begins approximately after 30-60 min, which can further continue up to 24 h. Due to a dose-dependent relationship, cyclopentolate hydrochloride’s side effects can be observed both in an ocular and systemic manner which may occur if solutions more than 0.5% concentration are used. Herein, we report central anticholinergic syndrome due to the administration of excessive amounts of cyclopentolate hydrochloride in a child.Öğe Children with urİnary tract isolated from cultures of microorganisms and antibiotic resistance rates(Anatolian Journal of Clinical Investigation, 2014) Aylanç, Hakan; Topaloğlu, Naci; Battal, Fatih; Yildirim, Şule; Bİnnetoğlu, Fatih Köksal; Tekİn, Mustafa; Tekİn, Satı ZeynepUrinary tract infections (UTI) are one of the most common infections in childhood. Resistance is a major problem due to common use of wide-spectrum antibiotics. In the present study we aimed to identify the pathogens of UTI in our clinic and define the resistance pattern of these pathogens.We scanned the urinary cultures and antibiograms of the children applied to our outpatient clinic between August 2011 and December 2013. Urinary cultures of 217 children were studied. Of the 217 studied children 176 (81.1%) were girls and 4 (18.9%) were boys. Of the 52 patients under one year 38 (73%) were girls and 14 (27%) were boys. The age of the cases were between 0.01 and 17.80 decimal years (mean: 5.6). The pathogens were E. Coli in 64.1%, Klebsiella spp. İn 16.1%, Pseudomonas aeruginosa in 6.5%, Enterococcus spp in 4.6%, Enterobacter spp in 3.2%, Proteus spp in 2.8%, Staphylococcus spp. İn 1.9%, Streptococcus spp in 1%. there was a high resistance against ampicillin, amoxicillin-clavulanate and trimethoprin-sulfamethoxazole. The present study proved the importance of culture and antibiogram. Until antibiogram results oral cephalosporins can be used as a first line empirical treatment. If the antibiogram could not be done regional resistance status should be known for the succesful treatment. © 2014, Anatolian Journal of Clinical Investigation. All rights reserved.Öğe Delayed time of atrial conduction in children with Familial Mediterranean Fever(2021) Şehitoğlu, M.Hilal; Binnetoğlu, Fatih Köksal; Aylanç, Hakan; Yıldırım, Şule; Kaymaz, Nazan; Özdemir, ÖztürkIntroduction: Familial Mediterranean Fever (FMF) is a disease with recurrent fever, characterized by painful, noninfectious inflammation of the serous membranes. It mostly affects Armenians, Turks, Arabs and Jews. Prolonged inflammation in FMF may lead to atrial fibrosis which can cause the deterioration of atrial conduction time and refractory periods of atrial myocardium. In the present study we aimed to assess atrial conduction time in children with FMF. Methods: The study included 36, children diagnosed with FMF(17 males/19 females, 13 (7-15) years) and 20 control(7 males/13 females, 11 (9- 16) years) cases in our Pediatric Outpatient Clinic between October 2015 and October 2016. Tissue Doppler Echocardiography (TDE) measurements of intra-and interatrial electromechanical delay were done. P wave dispersion (Pdisp) was calculated from the 12-lead electrocardiogram. Results: Inter-atrial (Lateral PA– Tricuspid PA) and Intra-left (Lateral PA-Septal PA) atrial electromechanical delay were significantly longer in FMF patients (P<0.001,respectively). (PA: the time range between the beginning of the P wave in the surface electrocardiogram and the beginning of the tissue Doppler late diastolic wave A). Also, P-wave dispersion (Pdisp) were significantly higher in FMF patients ( p= 0.002). Conclusions: This study shows that atrial electromechanical delay and Pdisp are prolonged in children with FMF. We recommend that atrial conduction time be measured for children diagnosed with FMF.Öğe Diyabetik Anne Bebeklerinde Antropometrik Ölçümler İle Kord Kanı Tenascin-C, İnsülin Ve Glikoz Seviyelerinin İlişkisi(2018) Sürecek, Fehime Erdem; Aylanç, HakanGiriş: Bu çalışmada Kronik bir inflamatuar süreç olan diyabetten etkilenen fetüsün büyümesinde Tenascin-C’nin rolünün olup olmadığının araştırılması ve kordkanı Tenascin-C, insülin ve glikoz düzeylerinin karşılaştırılması amaçlanmıştır.Gereç ve Yöntemler: Bu prospektif çalışmaya gebelik haftası >376/7olan, diyabetik anne bebekleri (grup 1, n=25) ile annesinde diyabet olmayan sağlıklı bebekler (grup 2, n=35) dahil edildi. Bebeklerin boy, baş çevresi, tartı ve göğüs çevreleri aynı kişi tarafından ölçülüp kayıt edildi. Doğumda göbek kordonundan alınankan örneğinden Tenascin-C, insülin, glikoz düzeyleri çalışıldı.Sonuçlar: Prenatal diyabet maruziyeti olan grup 1 ile sağlıklı yenidoğanlardan oluşan grup 2‘nin kord kanı Tenascin-C seviyeleri karşılaştırıldığında istatistikselolarak anlamlı fark bulundu (p<0,001). Her iki grubunda kord kanında bakılan glikoz ve insülin düzeyleri arasında istatistiksel olarak anlamlı fark bulunmadı(p=0,57). Gruplar arasında antropometrik ölçümler (vücut ağırlığı, boy, baş çevresi, göğüs çevresi) karşılaştırıldığında istatistiksel olarak anlamlı fark bulunmadı.Kord kanı Tenascin-C düzeyi ile antropometrik ölçümlerin korelasyonunda istatistiksel olarak bir anlamlılık bulunmadı. İnsülin ve Tenascin-C seviyeleri arasındaorta düzeyde negatif korelasyon saptandı (r=-0,464; p=0,019).Tartışma: Sonuç olarak diyabetik anne bebeklerinin komplikasyon yaşamamış olsalar bile kontrol grubuna göre Tenascin-C seviyelerinin anlamlı derecede yüksek olduğu gösterildi. Bu nedenle gebelik süresince inflamasyona maruz kalan diyabetik anne bebekleri ile ilgili daha geniş prospektif çalışmalara ihtiyaç vardır.Öğe Effect of infant feeding on epicardial fat thickness in normal weighted children(Anatolian Journal of Clinical Investigation, 2015) Yildirim, Şule; Binnetoğlu, Fatih Köksal; Aylanç, Hakan; Battal, Fatih; Tekin, Mustafa; Kaymaz, Nazan; Topaloğlu, NaciEFT is an independent predictor of coronary artery disease and closely associated with increased risk of metabolic syndrome and cardiovascular complications. This study aimed to evaluate the effect of breastfeeding on EFT thickness in normal-weighted children to predict the increased risk of coronary artery disease. This study included 84 normal weighted children (aged between 5-10 years), who admitted to pediatric cardiology department from October 2013 to March 2014. The patients were divided into 3 groups according to the feeding regimen in the first 6 months of year. Group 1 consisted of children who were exclusively breastfed in the first 6 months (n: 45). Group 2 consisted of children who were fed with both breast milk and formula (n: 37) and the Group 3 included children who only fed with formula (n: 2). Transthoracic echocardiography was performed and epicardial fat tissue measured. EFT was statistically lower in Group 1 compared to Group 2. EFT was highest in Group 3. The children who breastfed for longer time had low EFT thickness and this correlation was statistically significant (r= -0,457, p<0,001). In conclusion echocardiographically measured EFT thickness is low in breastfed children compared to formula-fed children. © 2015, Anatolian Journal of Clinical Investigation. All rights reserved.Öğe Evaluation of the Relationship Between Adolescents’ Internet Addiction Risks and Prosocial Behaviors(Galenos Publishing House, 2023) Kasap, Tolga; Kaymaz, Nazan; Aylanç, Hakan; Battal, FatihIntroduction: Prosocial behavior is defined as behavior that is done voluntarily, aiming to benefit another person or group. Prosocial behavior appears in preschool, around age two, and increases in frequency and variety throughout life. While the internet can provide many positive prospects, exposure to negative behaviors on the internet may cause an individual to normalize them over time, which eventually could cause humans to lose certain senses. As a fast-growing addictive behavior, internet addiction (IA) can lead to poor social communication, loneliness, depression, etc. However, it should be remembered that many positive behaviors may be learned through the internet. The present study aimed to evaluate the relationship between IA and prosocial behavior in adolescents. Materials and Methods: A cross-sectional study was conducted with healthy adolescents aged 10 to 18. The participants were asked to answer a questionnaire including socio-demographic information and two scales; i) Young’s Internet Addiction Scale-Short Form (YIAS-SF); for evaluating IA, ii) Child Prosociality Scale (CPS); for evaluating the tendency to engage in prosocial behaviors. The scale scores were compared with each other through the socio-demographic features of the participants. Results: The study sample consisted of 488 adolescents (292 females, 196 males) with a mean age of 13.75. The parameter that affected the YIAS-SF score most was found to be the adolescent’s duration of daily internet use (p<0.01 and ?=0.396), and it was determined that the parameter that affected the CPS score the most was school success (?=-0.166, p<0.001). A negative correlation was found between CPS and YIAS-SF (p=0,001, r=-0,269). Furthermore, there was a negative correlation between the adolescent’s CPS score and the mother’s daily internet use duration in comparison to the adolescent’s and the father’s (p=0.344 and r=-0.043). Conclusion: Since there is an inverse relationship between the risk of IA and prosocial behaviors, prosocial behaviors should be motivated in adolescents at high risk of IA. To promote prosocial behaviors in adolescents, mothers should be informed that the duration of their own daily internet time has a more significant effect on the adolescent’s prosocial behavior than the adolescent’s daily internet use time. ©Copyright 2023 by Bursa Uludağ University, Department of Pediatrics.Öğe First meconium time may be a predictive factor for infantile colic: a prospectivestudy(2018) Aylanç, Hakan; Kaymaz, Nazan; Köpük, Şule Yıldırım; Cevizci, Sibel; Vurur, Gülşen; Battal, FatihObjective: Meconium passage is a good marker of a normal gastrointestinal tract and the general health of a neonate.There are both gastrointestinal and non-gastrointestinal hypotheses for the etiology of infantile colic. The aim of thepresent study was to determine whether first meconium time could predict infantile colic (IC) later.Method: A follow-up study was conducted with 248 consecutive singleton full-term healthy neonates. The demographicvariables, age at first feed, time of first meconium, number of feeds until the first meconium, and number of defecationsduring the first 3 days of life were recorded. The characteristics of the neonates were analyzed for association with IC.Results: First meconium time was 9.7±10.2 h and 6.8±7.8 h in the IC and non-IC groups, respectively (p=0.014). Therisk of IC was increased by 1.99 times for those who did not have their first meconium until 5.75 h after birth (95% CI:1.13–3.51) and by 2.11 times for those who did not have more than 17 defecations in the first 72 h (95% CI: 1.19–3.74).Conclusions: Neonates who do not have their first meconium in the first 5.75 h after birth and who have fewer than 17defecations in the first 72 h of life are at risk of IC development.Öğe Glucagon-like peptide-2 May Assist to Protect against Valproic Acid Induced Hepatic Injury in Rats(2020) Öztopuz, Özlem; Aylanç, Hakan; Şehitoğlu, M.Hilal; Türkön, Hakan; Battal, Fatih; Demir, UfukVPA is widely used in epilepsy and other psychological disorders, increasing the probability of developing non-alcoholic liver diseasein long-term treatments. GLP-2 is a proglucagon belonging to the peptide family expressed in the intestine, pancreas and brain to date.Although there are many studies on the use of GLP-2 for therapeutic purposes on the gastrointestinal system, its effect on liver toxicityis unknown. We aimed to investigate the effect of GLP-2 administration on hepatic function in a rat model with VPA-inducedhepatotoxicity. Rats were injected intraperitoneally at 500 mg/kg and GLP-2 5µg/kg a day. The rats (200-250g) were separated into fourgroups (n=7). Group C was administrated 1 mL of 0.9% SF, Group GLP treated with GLP-2 (5µg/kg/day), Group GLP+VPA werereceived GLP-2 (5µg/kg) 1 h prior to VPA (500 mg/kg), Group VPA received VPA (500 mg/kg), 1 h prior to 1 mL of 0.9% SF ip (n=7).Liver tissues were used to investigate effects of VPA and GLP-2 in the liver 15 days after application. While VPA caused moderate butsignificant liver damage according to biochemical results, mRNA expression of cytokines were found to significantly increase after theday 15. VPA administration significantly induced expression of Interleukin 1 beta (IL-1?), Tumor necrosis factor alpha (TNF-?),Interleukin 10 (IL-10). In contrast, GLP-2 treatment reduced expression of IL-1?, TNF-? and IL-10. Also malondialdehyde (MDA),glutathione s-transferase (?-GST), superoxide dismutase activities (SOD), total antioxidant status (TAS) and total oxidant status (TOS)levels were estimated. GLP-2 had positive effects on both liver enzymes and oxidative stress markers in VPA-induced hepatotoxicity.These results suggest that endogenous GLP-2 administration is associated with a mechanism that moderately protects liver tissue.Öğe Influence of body mass index on mindfulness awareness and coping methods for stress in adolescents(Walter de Gruyter GmbH, 2018) Kaymaz, Nazan; Düzçeker, Yasemin; Uzun, Mehmet Erdem; Aylanç, Hakan; Baştürk, Meryem; Yildirim, ŞuleObjective: Psychological state may affect the body weight through the hypothalamus and vice versa. The goal of this study is to investigate whether body mass index affect mindfulness awareness (MA) levels and type of coping with stress. Methods: Healthy adolescents were included in the study. The mindfulness attention awareness scale (MAAS), indicating the ways of coping checklist inventory was performed and body mass index (BMI) (kg/m2) of adolescents were calculated. The influence of BMI on MA and ways of coping with stress was tested. According to BMI percentiles the study population was grouped as obese (including overweight), normal-weighted and underweight. Results: A total of 270 adolescents (mean age: 13.63±2.07 years; 165 female/105 male) participated in the study. No significant correlation was found between BMI and MA scores (r //-0.085; p -0.161) and coping strategies were not different between the groups. When MA scores are compared with stress coping methods, it appeares that participants with high awareness levels chose positive coping styles. Conclusion: BMI is not effective on MA levels and choice of stress coping methods. But the higher MA levels are associated with positive coping styles. © 2018 Walter de Gruyter GmbH, Berlin/Boston.Öğe Multi-vitamin intake during pregnancy: Is it a causative factor for childhood obesity?(2015) Topaloğlu, Naci; Uysal, Ahmet; Tekin, Mustafa; Yıldırım, Şule; Binnetoğlu, Köksal; Kaymaz, Nazan; Aylanç, HakanAmaç: Çalışmamız, gebelikte multivitamin kullanımının çocukluk çağı obezitesinde nedenlerden biri olup olmadığını araştırmak amacıyla yapılmıştır. Gereç ve Yöntem: Çalışma prospektif vaka kontrol çalışmasıdır. İlk gruba VKIinegöre obez tanısı konmuş 50 çocuk, ikinci gruba ise sağlıklı 50 çocuk alındı.Prematüreler, mental retardasyonu olanlar, kronik hastalığı olanlar, sendro-mik çocuklar ve sorulara yeterli cevap veremeyenler çalışmaya dahil edilmedi.Çalışma annelerin anket formlarını doldurması ile gerçekleştirildi. Vücut ağırlığı ve boy gibi antropometrik ölçümler aynı araştırmacı tarafından yürütüldü.Bulgular: Obez gruptaki çocukların yaş ortalamaları 10,34±3,68 yıl iken kontrol grubundakilerin 8,88 ± 3,96 yıl idi. İki grup arasında doğum şekli, doğumhafası, doğum ağırlığı açısından istatistiksel olarak fark yoktu. Obez ve kontrol grundaki çocukların annelerinin multivitamin kullanması açısından aralarında bir fark yoktu. Tartışma: Çalışmamızda gebelikte multi-vitamin desteğinin çocukluk çağı obezitesi üzerine etkili olmadığı bulunmuştur. Konuyla alakalı daha büyük ve detaylı çalışmalara ihtiyaç vardır.Öğe Pre-conception folic acid intake and attention deficit and hyperactivity disorder in children(2023) Uzun, Mehmet Erdem; Kaymaz, Nazan; Aylanç, Hakan; Gökten, Emel Sarı; Şirin, Hande; Şehitoğlu, M.HilalObjectives: Attention Deficit Hyperactivity Disorder (ADHD) is a common disorder in children. It is thought to occur due to the interaction of many genetic and environmental factors during early development. Many studies have been conducted to investigate the etiology of ADHD. Some have investigated neurobiology, and others have investigated malnutrition and trace element deficiency. To investigate the effect of folic acid intake during the pre-conception period in terms of ADHD development. Methods: Five hundred and ninety-eight participants, 246 children with ADHD, and 352 healthy controls were enrolled. A questionnaire was completed, including socio-demographic information and the use of folic acid and other supplements such as a multivitamin, iron, and omega 3 during pregnancy. Data were examined to determine associations with ADHD. Mann-Whitney U tests for continuous variables, Pearson’s chi-square, and Fisher’s exact tests for categorical variables were used to compare groups. Results: The use of folic acid during pre-pregnancy among mothers who had a child with ADHD was 13% and this was 31% in the control group (p < 0.001). There was no statistically significant difference between the groups’ use of folic acid in pregnancy (p = 0.617). Other situations related to ADHD were advanced maternal age (p < 0.001 for both groups), abnormal double screening test results in pregnancy (27% vs. 5%, p < 0.001) and omega 3 use in pregnancy (p < 0.001). Conclusions: The use of folic acid before and during pregnancy is important for neurological development. However, there is little data on use before pregnancy in the literature. This study shows that folic acid taken before pregnancy may prevent ADHD in childhood. The present study recommends folic acid usage in planned pregnancy to prevent ADHD in the child.Öğe Right Aortic Arch with Aberran Left Subclavian Artery; Accompanied with Crossed Pulmonary Arteries: A Rare Association(2016) Aylanç, Hakan; Aylanç, Nilüfer; Binnetoğlu, Fatih Köksal; Battal, Fatih; Adam, Gürhan; Tekin, Mustafa; Kaymaz, Nazan[Abstract Not Available]Öğe Serum ischemia-modified albumin levels in adolescent smokers(Walter de Gruyter GmbH, 2018) Battal, Fatih; Tekin, Mustafa; Aylanç, Hakan; Ylldlrlm, Şule; Türkön, Hakan; Binneto?lu, Fatih Köksal; Kaymaz, NazanIt is known that the biochemical marker linked to tissue ischemia, ischemia-modified albumin (IMA), is related to oxidative stress. Cigarette smoking is a situation with increased oxidative stress causing cell damage and it is thought that many of the negative effects linked to smoking may occur after the biological material in the body is exposed to oxidative damage. This study aimed to identify variability in serum IMA levels in adolescents who smoke. This case-control study comprised 60 adolescents without any chronic disease. The smoking group was 30 adolescents between the ages of 14 and 17 years who smoked, while the control group was 30 healthy adolescents who did not smoke. Blood samples were collected from all subjects and serum IMA levels and serum nicotine metabolites were determined. The serum IMA levels in the adolescents who smoked were 0.452±0.094 absorbance unit (ABSU), while the control group had ASBU levels of 0.427±0.054. There was no significant difference between the groups in terms of serum IMA levels (p=0.210). There was a significant difference between the control and smoking groups in terms of serum nicotine metabolite levels (p<0.001). Among adolescents who smoke, serum IMA levels may not be a good marker for oxidative stress. © 2018 Walter de Gruyter GmbH, Berlin/Boston.Öğe Topikal steroid kullanımına bağlı iyatrojenik adrenokortikal yetmezlik(Çanakkale Onsekiz Mart Üniversitesi, 2013-06) Tekin, Mustafa; Topaloğlu, Naci; Yıldırım, Şule; Binnetoğlu, Köksal Fatih; Kaymaz, Nazan; Aylanç, Hakan; Battal, Fatih; Aşık, Zuhal[No Abstract Available]
