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Öğe A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression(Elsevier Science Bv, 2014) Altinbas, Kursat; Ozerdem, Aysegul; Prieto, Miguel L.; Fuentes, Manuel E.; Yalin, Nefize; Ersoy, Zeliha; Aydemir, OmerBackground: Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. Methods: The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (IAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BR Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. Results: There was no significant difference between mood groups in the mean rnHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. Limitations: Small sample size and cross-sectional design. Conclusion: Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments. (C) 2013 Published by Elsevier B.V.Öğe Different patterns of manic/hypomanic symptoms in depression: A pilot modification of the hypomania checklist-32 to assess mixed depression(Elsevier, 2015) Prieto, Miguel L.; Youngstrom, Eric A.; Ozerdem, Aysegul; Altinbas, Kursat; Quiroz, Danilo; Aydemir, Omer; Yalin, NefizeBackground: There are no self-report scales that assess manic/hypomanic symptoms in patients with depression. The aim of this study was to explore the use of a modified screening instrument for bipolar disorder to assess current manic/hypomanic symptoms in patients with a depressive episode. Methods: The study sample consisted of 188 patients with Structured Clinical Interview for DSM-IV-TR disorders (SCID) confirmed bipolar or major depressive disorder. We modified the Hypomania Checklist-32 (mHCL-32) to assess current instead of lifetime symptoms. An Exploratory Factor Analysis (EFA) was conducted to identify clusters of mHCL-32 items that were endorsed concurrently. A Latent Class Analysis (LCA) was carried out to identify groups of patients with similar mHCL-32 item endorsement patterns. Results: The EPA identified 3 factors: factor #1 (elation-disinhibition-increased goal directed activity), factor #2 (risk-taking-impulsivity-substance use) and factor #3 (distractibility-irritability). The LCA yielded 3 classes (2 showing manic/hypomanic features). While class #1 patients endorsed more items related to disinhibition and racing thoughts, class #2 patients recognized more items associated with irritability and substance use Limitations: Lack of an adequate gold standard measure of mixed depression to compare to, the cross-sectional design and the lack of a validation sample. Conclusions: The mHCL-32 scale allowed a comprehensive and convergent delineation of hypomanic/manic symptoms in depression. Further validation of these findings is needed. (C) 2014 Elsevier B.V. All rights reserved,Öğe Reliability and Validity Study of the Turkish Version of Hypomania Checklist-32-Revised(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2017) Vahip, Simavi; Aydemir, Omer; Akkaya, Cengiz; Altinbas, Kursat; Kora, Kaan; Suculluoglu Dikici, Didem; Akdeniz, FatmaObjective: In this study, it is aimed to evaluate the reliability and validity of the Turkish version of Hypomania Checklist-32-Revised. Method: The study was carried out with 80 patients diagnosed with bipolar I disorder, 26 patients diagnosed with bipolar II disorder and 42 patients diagnosed with major depressive disorder attending the out- and in-patient psychiatry departments of three university hospitals and one training hospital, and 116 healthy volunteers consisting of university students. Mean duration of illness was 15,1 years for the bipolar disorder group, and 9,3 years for the major depressive disorder group. For concurrent validity, Mood Disorder Questionnaire was used. In the statistical analysis, internal consistency coefficient, item-total score correlation coefficients, exploratory factor analysis, correlation with concurrent scale and ROC curve were calculated. Results: Translation into Turkish and back-translation into English of Hypomania Checklist-32-Revised were performed and thus the semantic harmony of the scale was obtained. In the internal consistency, Cronbach alpha coefficient was 0,914 and item-total score correlations were between 0,235-0.743. Solely the coefficient of item #23 was found as 0,110. In factor analysis, six factors were obtained but a two-factor solution representing 44,5% of the total variance was accepted and first factor represents overactivity and being expansive, second factor represents impulsivity and risky behaviors. Correlation of Hypomania Checklist-32-R with Mood Disorder Questionnaire was r=0,379. In the ROC analysis, the cut off point of the scale was calculated as 14 with a sensitivity of 71,0 and specificity of 69,8. The scale discriminates well between the bipolar group, and depressive and control groups. Conclusion: Hypomania Checklist-32-Revised developed for screening hypomania is reported to be reliable and valid in Turkish after cutting out item #23.Öğe Temperament characteristics in patients with panic disorder and their first-degree relatives(W B Saunders Co-Elsevier Inc, 2015) Altinbas, Gulcin; Altinbas, Kurst; Guloksuz, Selin Aktan; Guloksuz, Sinan; Aydemir, Omer; Ozgen, GulizAim: Panic disorder is one of the highly heritable anxiety disorders; and temperament characteristics are considered predicting liability to panic disorder. Accumulating evidence suggests temperament characteristics are intermediate phenotypes for clinical conditions. Given this background, we aimed to investigate temperament characteristics in patients with panic disorder, their first-degree relatives, and healthy controls. Method: Study sample was consisted 60 patients with panic disorder, 37 first-degree relatives of these patients, and 37 age, gender, and education level matched healthy controls (HC). SCID-I, the Panic Agoraphobia Scale, and the State and Trait Anxiety Inventory were applied to assess clinical characteristics of the patient group. Temperament characteristics were assessed using the Temperament Evaluation of Memphis, Pisa, Paris, San Diego Autoquestionnaire (TEMPS-A). Results: Anxious, depressive, cyclothymic, and irritable temperament scores of patients were higher than those of HC. There was no difference between the patients and the relatives, with the exception of higher anxious temperament scores in patients. Conclusion: Overall, our findings suggest that anxious temperament characteristic might be a trait marker for liability to panic disorder. Further research with a prospective design in a larger sample is required to confirm our findings. (C) 2015 Elsevier Inc. All rights reserved.Öğe The Impact of Psychotropic Drugs on Psychosocial Functioning in Bipolar Disorder(Kure Iletisim Grubu A S, 2014) Aydemir, Omer; Aydin, Pinar Cetinay; Oyeckin, Demet Gulec; Gulseren, Seref; Koybasi, Gulperi Putgul; Sahin, HasanObjective: Even though bipolar patients achieve remission, they do not reach. premorbid psychosocial functioning. Factors such as residual depressive symptoms and number of episodes may cause this effect. The impact of treatment modalities has not been adequately studied. The aim of this study was to evaluate the impact of treatment modalities on psychosocial functioning in remitted bipolar patients. Methods: The study was carried out with 108 patients diagnosed as having bipolar disorder. All patients were in remission and the remission state was confirmed by rating scales. In the assessment of functioning, the Functioning Assessment Short Test (FAST) covering domains such as autonomy, occupational functioning, cognitive functioning, financial issues, interpersonal relations, and leisure time activities was applied. The treatment modalities were mood stabilizers (MS) versus mood stabilizers plus second-generation antipsychotics (MS+SGA). While 38% (n=41) of the patients were on MS only, 67 patients (62%) were on MS+SGA. In the statistical analysis, multiple linear regression analysis was performed. Results: In multiple linear regression analyses, the models concerning autonomy, interpersonal relations, and leisure time were statistically significant. In patients on MS+SGA, autonomy (Beta=3.086, p<0.01), interpersonal relations (Beta=2.807, p<0.01) and leisure time activities (Beta=3.293, p<0.01) were affected negatively. Similarly, total HAM-D score had negative effects on the same domains. Conclusion: Beside residual depressive symptoms, second-generation antipsychotics used in the treatment seem to affect psychosocial functioning negatively.Öğe The impact of second generation antipsychotics on psychosocial functioning in bipolar disorder(Springer, 2014) Aydemir, Omer; Cetinay-Aydin, Pinar; Gulec-Oyeckin, Demet; Gulseren, Seref; Putgul-Koybasi, Gulperi; Sahin, Hasan[Anstract Not Available]
