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    Adipokines, inflammation, oxidative stress: Critical components in obese women with metabolic syndrome
    (Mattioli 1885, 2021) Yılmaz, Sevil Karahan; Eskici, Günay; Mertoğlu, Cuma; Ayaz, Aylin
    Objective: Adipose tissue dysfunction, increased systemic inflammation and oxidative stress are features of metabolic syndrome. The purpose of the present study was to determine the relationship between adipokines, inflammation, oxidative stress and metabolic syndrome components in obese women. Subjects and Methods: A total sample of 100 obese women (BMI=32.44±1.80 kg/m2) living in Erzincan aged 20-45 years were included in this cross-sectional survey. Serum biochemical (leptin, adiponectin, resistin, lipit profiles, fasting plasma glucose, fasting plasma insulin, high sensitivity C-reactive protein, tumor necrosis factor-alfa, interleukin-6, malondialdehyde, anthropometrical (body weight, height, waist and neck circumference) parameters and blood pressure were measured. Metabolic syndrome was defined according to National Cholesterol Education Program Adult Treatment Panel-III (NCEP-ATP III) criteria. Results: Results of this study indicate that waist circumference, neck circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma insulin (FPI), HOMA-IR, triglyceride (TG), high sensitivity C-reactive protein (Hs-CRP), Tumor Necrosis Factor -alfa (TNF-α), leptin, leptin: adiponectin (L:A) ratio and malondialdehyde (MAD) were significantly higher but adiponectin and HDL-Cholesterol (HDL-C) were significantly lower in obese women with metabolic syndrome than in women without the syndrome (p <0.05). Waist circumference had positive correlation with Hs-CRP (r = 0.315, p < 0.05) and negative correlation with adiponectin (r =- 0.552, p < 0.01). TG had highly significant positive correlation with Hs-CRP (r = 0.305, p < 0.05) but, negative correlation with IL-6 (r = -0.347, p < 0.05) and adiponectin (r=-0.440, p< 0.01). Hs-CRP was positively correlated with MDA (r=0.323, p< 0.05) and negatively correlated with DBP (r=-0.253, p< 0.05). TNF-α was significantly and positively correlated with leptin (r = 0.701, p < 0.01), resistin (r = 0.646, p < 0.01), MDA (r = 0.949, p < 0.01) and negatively correlated with adiponectin (r =-0.772, p < 0.01). MDA had positive correlation with TNF-α (r = 0.949, p <0.01), leptin (r = 0.721, p < 0.01), adiponectin (r = 0.788, p< 0.01) and resistin (r = 0.694, p < 0.01). Hs-CRP was significantly and positively associated with waist circumferemce (β = 0.315, p < 0.05), TG (β = 0.307, p < 0.05) and negatively associated with DBP (β = -0.276, p < 0.05). Conclusion: High leptin and low adiponectin level, L:A ratio, Hs-CRP, TNF-α and MDA may act as a diagnostic marker for metabolic syndrome in obese women.
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    Effect of different protein diets on weight loss, inflammatory markers, and cardiometabolic risk factors in obese women
    (Wolters Kluwer Medknow Publications, 2021) Yılmaz, Sevil Karahan; Eskici, Günay; Mertoğlu, Cuma; Ayaz, Aylin
    Background: Reducing and maintaining body weight has become more important than ever as obesity is becoming increasingly common worldwide. This study was aimed to investigate the effects of diets with different protein contents administered to obese women on anthropometric measurements, inflammatory markers, and cardiometabolic risk factors. Materials and Methods: This randomized controlled trial was conducted with sixty volunteering obese women aged between 20 and 45 years. The subjects were divided into two groups in equal numbers. The high-protein (HP) group (n = 30) was administered an iso-caloric HP diet (25% protein, 30% fat, and 45% carbohydrate), and the control group (n = 30) an isocaloric low-protein diet (15% protein, 30% fat, and 55% carbohydrate), and both groups were followed up for 8 weeks. The subjects' descriptive data, anthropometric measurements, homeostatic model assessment-insulin resistance (HOMA-IR), lipid profiles, and high-sensitive C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-), and interleukin-6 (IL-6) levels were analyzed. Results: There was no significant difference at baseline (except for low-density lipoprotein cholesterol [LDL-C]), and end-of-study (except for IL-6, systolic blood pressure [SBP], and diastolic blood pressure) values of parameters between the two groups; after adjusted for baseline measurements, a significant difference was observed between the groups for body weight, body mass index, waist circumference, HOMA-IR, LDL-C, hs-CRP, TNF-, IL-6, and SBP (P = 0.004, P = 0.001, P = 0.003, P = 0.029, P = 0.004, P = 0.016, P = 0.004, P = 0.010, and P = 0.000, respectively) and were greater in the HP group than in the control group (P < 0.05). Conclusion: The HP diet was effective on improvement in HOMA-IR, SBP, LDL-C, hs-CRP, TNF-, IL-6, and resulted in body weight loss.
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    Öğe
    Sebze amaçlı sakız fasulyesi (Cyamopsis tetragonoloba L.) yetiştiriciliğinde uygun sıra üzeri ve sıra arası mesafenin belirlenmesi
    (Çanakkale Onsekiz Mart Üniversitesi, 2019) Ayaz, Aylin; Akçura, Mevlüt
    Çalışma, sakız fasulyesinin (Cyamopsis tetragonoloba L.) sebze amaçlı yetiştiriciliğinde farklı sıra arası ve sıra üzeri mesafelerin verimine ve verim öğelerine olan etkisini belirlenmek amacıyla 2017 senesinde Edirne koşullarında yürütülmüştür. Deneme bölünmüş parseller deneme desenine göre 3 tekerrürlü olarak kurulmuş, sıra arası aralıkları 20 cm, 30 cm, 40 cm, 50 cm, sıra üzeri aralıkları ise 10 cm, 20 cm ve 30 cm olacak şekilde tertiplenmiştir. Araştırmadan elde edilen sonuçlara göre hem sıra arası hem de sıra üzeri mesafe bakımından bitkide tane sayısı, tanede kotiledon oranı, bakla uzunluğu, bitkide bakla sayısı, tane verimi, yeşil bakla verimi, bin tane ağırlığı arasındaki farklar istatistiki olarak önemli bulunurken, incelenen diğer özellikler arasındaki farklar ise önemsiz olmuştur. İncelenen bütün özelliklerin çoğunluğunda en yüksek değerler 30 cm sıra arası aralığında ve 10 cm sıra üzeri mesafelerde tespit edilmiştir. Netice olarak sakız fasulyesinin sebze amaçlı yetiştirilmesi halinde 30 cm sıra aralığında ve 10 cm sıra üzeri aralıkta ekilmesi uygun bulunmuştur.