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    Effects of reduced glutathione on nitric oxide level, total antioxidant and oxidant capacity and adenosine deaminase activity
    (Verduci Publisher, 2010) Atakisi, O.; Erdogan, H. M.; Atakisi, E.; Citil, M.; Kanici, A.; Merhan, O.; Uzun, M.
    The aim of this study was to determine the effect of exogenous GSH, an important antioxidant containing thiol group, on total antioxidant capacity (TAC) and total oxidant capacity (TOC), adenosine deaminase (ADA), a significant indicator of cellular immunity, and nitric oxide (NO) concentrations in rabbits. Sixteen healthy New Zealand rabbits were divided into 2 groups as control and GSH-treated group. Animals in control group received single intraperitoneal (ip) administration of 0.9% saline. Rabbits in GSH-treated group received reduced L-glutathione (10 mg/kg) (ip). Blood samples were taken from the marginal ear vein 0, 3, 6 and 12 hours after injection. Plasma TAC and NO levels were not statistically different between control and GSH group at 0 and 12 hours. Plasma TAC level was found to be significantly higher (p<0.05) while NO level was found to be significantly lower (p<0.05) in GSH treated group when compared to control group at 3 and 6 hours. Plasma TOC and ADA activity were not statistically different between control and GSH group during experiment. In conclusion, exogenous GSH resulted in an alteration of TAC and NO but not TOC and ADA, so exogenous GSH may be a valuable enhancer of the antioxidant system.
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    Öğe
    Effects of therapeutic dose of ivermectin on plasma nitric oxide and total antioxidant capacity in rabbits
    (Verduci Publisher, 2009) Atakisi, E.; Atakisi, O.; Topcu, B.; Uzun, M.
    Background: Ivermectin, an acaricide and anthielmintic drug of the family of avermectins may produce free radicals thus resulting cytotoxic effect on the parasite. Nitric oxide (NO) acts as free radicals and as host defense mechanisms. The antioxidant capacity (TAC) can be described by the analysis of single components in the defense systems against free radicals. It was aimed to study the effects of therapeutic doses of ivermectin on the plasma adenosine deaminase (ADA) and gamma glutamyl transpeptidase activities (GGT), total antioxidant capacity (TAC), nitric oxide (NO) and total protein, albumin, globulin levels in rabbits. Material and Methods: Twenty healthy New Zealand rabbits were allocated to 2 equal groups. Group I received 0.5 mg/kg and Group II received 1 mg/kg of ivermectin via subcutaneous injection. Blood samples were collected before the experiment, at 24 and 120 hours following the treatments. Results: Ivermectin at therapeutic doses increased plasma NO level at 24 h while decreased TAC at 120 h and did not alter other parameters. Conclusion: These findings may suggest that ivermectin is a safe antiparasitic drug for mammals but to less extent, it may have an effect on the oxidant/antioxidant balance.