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    677C>T and 1298A>C Polymorphisms of Methylenetetrahydropholate Reductase Gene and Biochemical Parameters in Turkish Population with Spina Bifida Occulta
    (Turkish Neurosurgical Soc, 2010) Eser, Betul; Cosar, Murat; Eser, Olcay; Erdogan, Mujgan O.; Aslan, Adem; Yildiz, Handan; Boyaci, Gazi
    AIM: This study aimed to investigate the 677C>T and 1298A>C MTHFR gene polymorphisms and their metabolic effects on the levels of folate, vitamin B12 and homocysteine in the serum of Turkish spina bifida occulta (SBO) patients and healthy individuals in disease. MATERIAL and METHODS: A case-control study was performed to detect 677C>T and 1298A>C MTHFR gene polymorphisms in 39 SBO patients and 34 healthy individuals. The folate, vitamin B12 and homocysteine concentrations in the serum of SBO and healthy individuals were evaluated and compared with MTHFR gene polymorphisms. RESULTS: 677 CC/CT/TT MTHFR genotype frequency differences between the SBO patients and controls were not significant (x(2)=3.325, P=0.068; x(2)=1.479, P=0.224; x(2)=0.275, P=0.600; respectively). 1298A>C MTHFR genotype frequency differences between the SBO patients and controls were significant (x(2)=8.477, P=0.004). The frequencies of the A and C alleles of the 1298A>C polymorphism did not differ in a statistically significant manner between the groups (x(2)=0.576, P=0.448). The biochemical parameters were not significantly different between SBO patients and healthy individuals (P>0.05). CONCLUSION: The 677C>T and 1298A>C polymorphisms of the MTHFR gene cannot be regarded as major risk factors for SBO in the Turkish patients 677TT homozygosity may affect the metabolism of homocysteine.
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    Intracerebral hematoma complicated with brain abscess in an infant - Case report
    (Japan Neurosurgical Soc, 2008) Eser, Olcay; Cosar, Murat; Aslan, Adem; Koken, Resit; Aktepe, Fatma; Esert, Betul
    A 45-day-old infant presented with a rare case of intracerebral hematoma complicated with brain abscess which developed after vitamin K deficiency. He was admitted to our emergency department with complaints of fever and confusion. Physical, neurological, and laboratory examinations and cranial computed tomography identified vitamin K deficiency and intracerebral hematoma. He started to suffer convulsions. The patient underwent surgery. A brain abscess was discovered with an intracerebral hematoma. The intracerebral hematoma and abscess were evacuated and antibiotic therapy was initiated. Convulsions became rare and were controlled with midozalam administration. Follow-up computed tomography after 6 months showed encephalomalacic changes in the temporoparietal area. If feeding depends only on human milk, the amount of vitamin K prophylaxis given to neonates should be increased to support vitamin K related factors.
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    Intradiploic cavernous hemangioma of the skull in a child: a case report
    (Springer, 2008) Cosar, Murat; Eser, Olcay; Aslan, Adem; Korkmaz, Serhat; Boyaci, Gazi; Aktepe, Fatma
    Introduction Intradiploic cavernous hemangioma of the skull is seen rarely. Intradiploic cavernous hemangiomas arise from the intrinsic vasculature of the bone and generally picks up at the fourth and fifth decades. Discussion and conclusion In this report, we present a 16-year-old child who was admitted with a swelling lesion in the right parietal bone and diagnosed as cavernous hemangioma after total extirpation.
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    The analyses of C677T and A1298C Polymorphisms on the MTHFR gene and Factor V Leiden mutation in Pseudotumor Cerebri Patients
    (Gene Therapy Press, 2013) Cosar, Murat; Eser, Betul; Erdogan, Mujgan Ozdemir; Eser, Olcay; Aslan, Adem; Yildiz, Handan; Korkmaz, Serhat
    Background: In this study, we aimed to investigate the genetic factors which may cause to thrombosis such as C677T and A1298C methylen-thetrahydropholate reductase (MTHFR) gene polymorphisms and Factor V Leiden mutation. Methods: A case-control study was performed to detect C677T and A1298C MTHFR and Factor V Leiden gene polymorphisms in 30 patients which have headache and prediagnosed as pseudotumor cerebri (PC) after neurological examination and cranial magnetic resonance imaging. The intracranial pressures of the patients were measured via lumbar punction and 16 of 30 patients were diagnosed as PC and the rest 14 patients diagnosed as normal patients (control group). The C677T and A1298C polymorphisms of the MTHFR gene and Factor V Leiden polymorphisms in PC and normal patients were analyzed. Results: The 677 CC/CT and 677 CC/TT MTHFR genotypes between the PC patients and controls were significant. However, 677 CT/TT MTHFR genotypes between the PC patients were not significant. We were not found 677 TT genotype in control groups. We compared 1298 AA/AC/CC genotype frequencies between the PC patients and controls groups, and the difference was not significant. There were no participants with AA genotype of Factor V Leiden. A significant association was not found between GA/GG of Factor V Leiden genotypes between PC patients and controls groups. (chi(2)=0.01, P=0.72). Conclusion: We think that C677T polymorphisms of the MTHFR can be regarded as a risk factor for PC patients. However, A1298C polymorphisms of the MTHFR and factor V Leiden polymorphisms cannot be regarded as major risk factors for PC in the Turkish population.
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    Vertebral body pneumatocyst in the cervical spine and review of the literature
    (Turkish Neurosurgical Soc, 2008) Cosar, Murat; Eser, Olcay; Aslan, Adem; Korkmaz, Serhat; Boyaci, Gazi; Degirmenci, Bumin; Albayrak, Ramazan
    A pneumatocyst in the cervical spine is extremely rare and to our knowledge only a few reports have been published in the English literature. Although the etiology and natural course of vertebral body pneumatocyst is unclear, nitrogen gas accumulation is claimed. A 65-year-old-man was admitted to the emergency department with neck pain and numbness and incapacity in his both hands and fingers. The radiological images revealed a vertebral located pneumatocyst in the C4 cervical vertebra. In this report, we present a case of cervical pneumatocyst located in the C4 vertebral body. The clinical and radiological features and natural course of the pneurnatocyst were evaluated.