Yazar "Askarizadeh, Fatemeh" seçeneğine göre listele

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    Impact of statin therapy on CD40:CD40L signaling: mechanistic insights and therapeutic opportunities
    (Springer Heidelberg, 2024) Askarizadeh, Fatemeh; Karav, Sercan; Jamialahmadi, Tannaz; Sahebkar, Amirhossein
    Statins are widely utilized to reduce cholesterol levels, particularly in cardiovascular diseases. They interface with cholesterol synthesis by inhibiting the 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase enzyme. Besides their primary effect, statins demonstrate anti-inflammatory and immune-modulating properties in various diseases, highlighting the pleiotropic effect of these drugs. The CD40:CD40L signaling pathway is considered a prominent inflammatory pathway in multiple diseases, including autoimmune, inflammatory, and cardiovascular diseases. The findings from clinical trials and in vitro and in vivo studies suggest the potential anti-inflammatory effect of statins in modulating the CD40 signaling pathway and downstream inflammatory mediator. Accordingly, as its classic ligand, statins can suppress immune responses in autoimmune diseases by inhibiting CD40 expression and blocking its interaction with CD40L. Additionally, statins affect intracellular signaling and inhibit inflammatory mediator secretion in chronic inflammatory diseases like asthma and autoimmune disorders such as myasthenia gravis, multiple sclerosis, systemic lupus erymanthus, and cardiovascular diseases like atherosclerosis. However, it is essential to note that the anti-inflammatory effect of statins may vary depending on the specific type of statin used. In this study, we aim to explore the potential anti-inflammatory effects of statins in treating inflammatory diseases by examining their role in regulating immune responses, particularly their impact on the CD40:CD40L signaling pathway, through a comprehensive review of existing literature.
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    Phytochemicals as Modulators of NETosis: A Comprehensive Review on Their Mechanisms and Therapeutic Potential
    (Wiley, 2025) Askarizadeh, Fatemeh; Karav, Sercan; Sahebkar, Amirhossein
    Medicinal plants have a longstanding history in the treatment of various diseases, including infectious and inflammatory disorders. These therapeutic effects are attributed to the presence of bioactive compounds. Among these, phytochemicals, particularly polyphenols such as curcumin, luteolin, resveratrol, alkaloids, and terpenoids, play a significant role as a secondary metabolites with potent NETosis-modulating properties. Phytochemicals include a wide range of bioactive substances with various therapeutic properties, including anti-inflammatory, antibacterial, anticancer, anti-metastatic, and antioxidant effects. These compounds specifically target NETosis in inflammatory and autoimmune disorders such as rheumatoid arthritis, lupus erythematosus, psoriasis, and cancer. In such conditions, unregulated inflammatory responses lead to complications and disease progression. Innate immunity and neutrophils are recognized as the primary constituents of the immune response. NETosis is a process associated with neutrophils in the inflammatory response, which is initiated to eliminate pathogens; however, as it is dysregulated, it results in tissue damage. This process is initiated in order to eliminate external factors and modulate inflammatory pathways. However, excessive activation of NETosis leads to tissue damage and exacerbates inflammation. The phytochemicals discussed herein modulate NETosis through distinct mechanisms, including inhibiting or reducing key mediators such as MPO, NE, and ROS. This study provides the first comprehensive review systematically evaluating the active phytochemicals effect in the treatment of various diseases, with a special focus on their NETosis-modulating effects. We highlight their specific mechanism of action against NETotic pathways and clinical potential as targeted therapies for NET-driven disease.