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    Association Between Inherited Thrombophilia and Impaired Right Ventricular Function in Deep Vein Thrombosis Without Symptomatic Pulmonary Embolism
    (Sage Publications Inc, 2014) Asgun, Halil Fatih; Kirilmaz, Bahadir; Saygi, Serkan; Ozturk, Okan; Silan, Fatma; Karatag, Ozan; Kosar, Sule
    The aim was to evaluate the right ventricular function in patients with inherited thrombophilia and deep vein thrombosis (DVT) without pulmonary embolism. A total of 38 patients with DVT without symptomatic pulmonary embolism and 30 patients with varicose veins were enrolled. Clinical data, echocardiography, and 2 thrombophilic mutations were analyzed. Factor V Leiden (FVL) polymorphism was significantly frequent in the study group (P = .007). The difference in prothrombin G20210A polymorphism between the study and control groups was at a near-significant level (P = .058). There was statistically significant decrease in tricuspid annular plane systolic excursion values in patients with FVL and prothrombin G20210A polymorphism. Combined FVL and prothrombin G20210A polymorphisms were more closely related to the decrease in this value (P = .006). Deep vein thrombosis had no additional adverse effects on right ventricle. Impaired right ventricular systolic function occurs in FVL and prothrombin G20210A polymorphisms.
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    Compartment Syndrome of the Vein Donor Leg Following an Uneventful Coronary Artery Bypass Surgery
    (Wiley, 2013) Asgun, Halil Fatih; Kirilmaz, Bahadir
    Compartment syndrome (CS) is a very rare complication of coronary artery bypass surgery (CABG) due to elevated intra-compartmental pressure induced by ischemia-reperfusion injury. We report a patient with CS following an uneventful CABG and discuss its management.
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    Experimental acute myocardial infarction in rats: HIF-1?, caspase-3, erythropoietin and erythropoietin receptor expression and the cardioprotective effects of two different erythropoietin doses
    (Elsevier Gmbh, Urban & Fischer Verlag, 2013) Bagla, Aysel Guven; Ercan, Ertugrul; Asgun, Halil Fatih; Ickin, Meltem; Ercan, Feriha; Yavuz, Ozlem; Bagla, Suat
    The cardioprotective effects of two different doses of erythropoietin administration were analyzed in rats with experimental myocardial infarction. None, saline, standard-dose (5000 U kg(-1)) and high-dose (10,000 U kg(-1)) of human recombinant erythropoietin alpha were administered intraperitoneally in Wistar rats with myocardial infarction induced by coronary artery ligation. Infarct sizes measured after triphenyltetrazolium chloride staining, levels of biochemical markers, histopathology examined by light and electron microscopy, and immunohistochemical expressions of erythropoietin, erythropoietin receptor, hypoxia inducible factor-1 alpha and caspase-3, were analyzed. Lower scores of infarction and hemorrhage, lower number of macrophages and higher score of vascularization surrounding the infarct area were observed in the erythropoietin administered groups (p < 0.05). Erythropoietin administration after myocardial infarction reduced the area of infarction and hemorrhage. There were hypoxia inducible factor-1 alpha and caspase-3 expressions in the marginal area, and erythropoietin and erythropoietin receptor expression in both marginal and normal areas (p < 0.001). Vascularization, erythropoietin expression in the normal area and vascular erythropoietin expression were positively correlated with human erythropoietin levels. The cardioprotective effects of erythropoietin treatment were independent of endogenous erythropoietin/erythropoietin receptor activity. Moreover exogenous erythropoietin treatment did not suppress endogenous erythropoietin. Erythropoietin administration after myocardial infarction reduced caspase 3 expression (apoptotic activity) and induced neovascularization around the infarct area. Higher erythropoietin administration did not provide an additional benefit over the standard-dose in myocardial protection. (C) 2013 Elsevier GmbH. All rights reserved.
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    Is contralateral carotis artery occlusion a risk factor for carotid andarterectomy?
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2016) Reyhanoglu, Hasan; Asgun, Halil Fatih; Ozcan, Kaan; Erturk, Murat; Durmaz, Isa
    Background: In this study, we aimed to investigate whether contralateral carotis artery occlusion poses an additional risk for morbidity and mortality in carotid endarterectomy. Methods: Between September 2010 and March 2015, a total of 135 patients (103 males, 32 females; mean age 68.3 years; range 46 to 92 years) who were operated with the diagnosis of carotid stenosis in our clinic were divided into two groups depending on the presence of an occluded contralateral artery. Thirty-two patients undergoing carotid endarterectomy with contralateral carotid artery occlusion were compared to 103 patients without contralateral occlusion. Baseline demographic characteristics, risk factors, type of surgical technique, postoperative early morbidity and mortality results of both groups were compared. Results: Both groups were similar according to their demographic and perioperative characteristics. There was no statistically significant difference in postoperative neurological [carotid occlusion group (CO) 6.3%, control group 6.8%, p= 0.638] or nonneurological (group CO 15.6%, control group 12.6%, p= 0.430) complications between the two groups. The length of hospital stay did not differ between both groups statistically while length of intensive care unit stay was significantly longer in the group with occlusion (p= 0.029). There was no significant difference in the postoperative mortality between the groups (group CO 0%, control group 1%, p= 0.763). Conclusion: Although morbidity and mortality are expected to be high in patients with contralateral carotid artery occlusion due to the limited cerebral blood supply, there was no significant increase in postoperative neurological complications, particularly. Therefore, we believe that contralateral occlusion does not pose an additional risk for surgery in patients undergoing carotid endarterectomy.
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    Systemic capillary leak syndrome during cardiac surgery
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2023) Asgun, Halil Fatih; Oguz, Sonay
    Systemic capillary leak syndrome is defined as excessive fluid and protein extravasation caused by microvascular hyperpermeability. It is a very rare condition, and may occur during or after any surgery without preceding symptoms or a suggestive history. It has been reported in pediatric cardiac surgery patients, and is not expected in adults. In this article, we present a 75-year-old female case of severe systemic capillary leak developed during coronary artery bypass grafting combined with dual valve replacement. To the best of our knowledge, this is the first adult case in the literature having an acute attack of systemic capillary leak syndrome during cardiac surgery.
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    The efficacy of a wearable hemodialysis with tentative equipment in chronic renal failure
    (E-Century Publishing Corp, 2020) Oguz, Sonay; Asgun, Halil Fatih; Bakirdogen, Serkan; Cakir, Dilek Ulker
    Objective: The aim of this study was to find an effective and simple method by which outpatient hemodialysis can be performed using diffusion and ultrafiltration methods with different procedures on a model. Methods: A solution containing high-level urea and creatinine similar to the blood values of patients with chronic renal failure was used, with the expectation of clearing it as in hemodialysis using a model with the designed system. The product values at the beginning and end of the process were determined, and the cleaning rates were calculated. Results: The clearance rates obtained in the serum were 79.2% for urea and 93.7% for creatinine. Greater than 65% clearance rates were detected in all products except calcium and magnesium. Statistical significance was found in all products (P < 0.05) except magnesium (P = 0.065). Conclusions: Using this method, we achieved a clearance rate greater than the desired clearance rates (65%) in hemodialysis.
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    The importance of individualized multimodality imaging-guided methods for selected patients in cardiac resynchronization therapy
    (Oxford Univ Press, 2022) Aksit, Ercan; Kucuk, Ugur; Altay, Servet; Taylan, Gokay; Asgun, Halil Fatih
    [Anstract Not Available]
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    The prevalence of VKORC1 1639 G>A and CYP2C9*2*3 genotypes in patients that requiring anticoagulant therapy in Turkish population
    (Springer, 2012) Silan, Coskun; Dogan, Omer Tamer; Silan, Fatma; Kukulguven, Fatma Mutlu; Asgun, Halil Fatih; Ozdemir, Semra; Uludag, Ahmet
    The aim was to investigate the prevalence of VKORC1 and CYP2C9 genotypes in patients requiring anticoagulant therapy in two different region's populations of Turkey. The recent cohort included 292 patients that needed anticoagulant therapy, and who had a history of deep vein thrombosis and/or pulmonary artery thromboembolism. Genomic DNA was isolated from peripheral blood samples and the StripAssay reverse hybridization or Real Time PCR technique was used for genotype analysis. Genotypes for CYP2C9 were detected as follows: 165 (56.5 %) for CYP2C9*1/*1, 67 (23.0 %) for CYP2C9*1/*2, 25 (8.6 %) for CYP2C9*1/*3, 9 (3.0 %) for CYP2C9*2/*2, 21 (7.2 %) for CYP2C9*2/*3, 5(1.7 %) for CYP2C9*3/*3 for CYP2C9 and the allele frequencies were: 0.723 for allele*1, 0.182 for allele*2 and 0.095 for allele*3 respectively. Genotypes for VKORC1 were detected as follows: 64 (21.9 %) for GG, 220 (75.4 %) for GA and 8 (2.7 %) for AA alleles. The G allele frequency was detected as 0.596, and the A allele frequency was 0.404. The VKORC1 1639 G > A and CYP2C9 mutation prevalence and allele frequency of the current results from two different populations (Sivas and Canakkale) showed similarly very variable profiles when compared to the other results from the Turkish population.