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    Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice
    (Taylor & Francis Ltd, 2016) Turgut, Nergiz Hacer; Mert, Derya Guliz; Kara, Haki; Egilmez, Hatice Reyhan; Arslanbas, Emre; Tepe, Bektas; Gungor, Huseyin
    Context: Morus nigra L. (Moraceae) has various uses in traditional medicine. However, the effect of M. nigra on cognitive impairment has not been investigated yet. Objective: The objective of this study is to determine the phenolic acid content and DNA damage protection potential of M. nigra leaf extract and to investigate the extract effect on cognitive impairment and oxidative stress in aging mice. Materials and methods: Phenolic acid content was determined by quantitative chromatographic analysis. DNA damage protection potential was evaluated on pBR322 plasmid DNA. Thirty-two Balb-C mice were randomly divided into four groups (control, d-galactose, d-galactose + M. nigra 50, and d-galactose + M. nigra 100). Mice were administered d-galactose (100 mg/kg, subcutaneous) and M. nigra (50 or 100 mg/kg, orally) daily for 8 weeks. Behavioral responses were evaluated with Morris water maze. Activities of antioxidant enzymes and levels of malondialdehyde (MDA) were assayed in serum, brain, and liver. Results: In extract, vanillic (632.093 mu g/g) and chlorogenic acids (555.0 mu g/g) were determined. The extract between 0.02 and 0.05 mg/mL effectively protected all DNA bands against the hazardous effect of UV and H2O2. Morus nigra significantly improved learning dysfunctions (p< 0.01), increased memory retention (p < 0.01), reduced MDA levels (p < 0.05), and elevated SOD, GPx, and CAT activities (p < 0.05) compared with the d-galactose group. Discussion and conclusion: These results show that M. nigra has the potential in improving cognitive deficits in mice and that M. nigra may be useful to suppress aging, partially due to its scavenging activity of free radicals and high antioxidant capacity.
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    Metal levels in organically and conventionally produced animal and vegetable products in Turkey
    (Taylor & Francis Ltd, 2013) Arslanbas, Emre; Baydan, Emine
    Lead, cadmium, copper, zinc and iron levels were determined in organically and conventionally produced wheat, green lentils, flower honey and eggs that are supplied on different markets in Ankara, Turkey. Their toxicological and nutritional values were compared with national and international limits and literature data. The levels of cadmium and lead in conventionally and organically produced wheat, green lentils, honey and egg were below the limit of detection (LOD), whereas the level of copper was only below LOD in honey and eggs. The levels of Zn and Cu were found to be higher in conventionally produced wheat samples than organically produced ones; whereas the level of Fe in organic products was found to be higher than the conventional products.
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    Öğe
    Prophylactic effect of N-acetylcysteine against sodium fluoride-induced blood oxidative stress in mice
    (Pergamon-Elsevier Science Ltd, 2010) Altintas, Levent; Essiz, Dinc; Eraslan, Gokhan; Ince, Sinan; Arslanbas, Emre
    Ninety female Balb/c mice were used. The animals were allocated to evenly six groups. While the first group was maintained as control. Groups 3, 4, 5, and 6 were administered 750 ppm, 1500 ppm, 3000 ppm, and 6000 ppm of N-acetylcysteine, respectively, for a period of 15 days. After day 15. Groups 2-6 were administered sodium fluoride, containing 100 ppm fluoride in drinking water, for another 15 days. Plasma malondialdehyde (MDA) levels and erythrocyte superoksid dismutase (SOD) and catalase (CAT) activities were determined at the beginning of the trial and on days 15 and 30. According to the data obtained in the present study, N-acetylcysteine, when administered at the indicated doses, did not produce a significant alteration in any of the three parameters investigated. On the other hand, while the plasma MDA level was determined to have increased significantly, erythrocyte SOD and CAT activities were ascertained to have decreased significantly in the group, which was administered sodium fluoride alone on day 30. In the groups, which were administered N-acetylcysteine prior to sodium fluoride, however, it was observed that, after sodium fluoride administration, plasma MDA levels and erythrocyte SOD and CAT activities drew closer to the values of the control group. (C) 2010 Elsevier Ltd. All rights reserved.