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    Effect of hemoglobin, albumin, lymphocyte, and platelet score on prognosis in intermediate-risk endometrial cancer according to molecular-based classification
    (Wiley, 2024) Ozdemir, Cem Yagmur; Cicekli, Nayif; Ahat, Betul; Marangoz, Bahar; Konus, Suleyman; Dur, Riza; Arioz, Dagistan Tolga
    ObjectiveThe aim of this study is to compare the relationship between molecular classification and HALP score in endometrial cancer (EC).MethodsPatients who were operated with the diagnosis of EC 2014 and 2024 were included in our study. 150 patients were included in the study. We divided the patients into three groups in terms of molecular classification; group 1 was the patients with POLE mutation, group 2 was the patients with MMRd and NSMP (intermediate prognosis), and group 3 was the patients with p53 mutation. Group 2 participants were divided into two groups, a low HALP score group and a high HALP score group, according to the HALP score cut-off value.ResultsUsing the value with the highest Youden's index (0.306) as a basis, it was demonstrated that the HALP score with a cut-off value of 33.735 has a sensitivity of 61.86% and a specificity of 68.75% in intermediate-risk EC. The 5-year overall survival (OS) was found to be 75.4% in intermediate-risk EC patients with low HALP scores and 91.5% in intermediate-risk EC patients with high HALP scores (p = 0.008). The 5-year progression-free survival (PFS) was found to be 86% in intermediate-risk EC patients with low HALP scores and 94.4% in intermediate-risk EC patients with high HALP scores (p = 0.089). MMR deficiency and NSMP have been considered intermediate-risk groups for endometrial cancer and are a heterogeneous group. Although the use of the HALP score to reduce this heterogeneity is successful in predicting OS, it is not sufficient for PFS.
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    Maternal and fetal leptin and ghrelin levels: relationship with fetal growth
    (Springer Heidelberg, 2011) Saylan, Filiz; Koken, Gulengul; Cosar, Emine; Koken, Tulay; Saylan, Arif; Arioz, Dagistan Tolga; Sahin, Figen
    In our study, we investigated the influence of plasma levels ghrelin, leptin and other metabolic hormones (ILGF-1 and ILGF-2) in pregnants in regulating fetal body weight and mode of delivery. A total of 36 appropriately healthy pregnants 19-36-year-old were involved in the study. Demographic chracteristics, serum ghrelin, leptin, IGF-1 and IGF-2 levels of the pregnants were studied. Plasma ghrelin and leptin levels did not differ significantly among trimesters and delivery, in contrast to IGF-I and IGF-II concentrations were significantly higher in the first half of the pregnancy (P < 0.05). Serum leptin was significantly associated with mode of delivery (r = 0.231; P = 0.008), BMI (r = 0.462; P = 0.004). Metabolic factors are associated with fetal growth, but in AGA babies, there were no differences between any parameter and clinical factor.