Yazar "Andic, Mehmet Fatih" seçeneğine göre listele

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    Quercetin, a powerful antioxidant bioflavonoid, attenuates renal dysfunction in long-term experimental diabetes mellitus
    (Marmara Univ, Fac Medicine, 2011) Edremitliolu, Mustafa; Andic, Mehmet Fatih; Sayin, Derya Beyza; Korkut, Oguzhan; Kisa, Ucler
    Objectives: Diabetes mellitus (DM) can cause serious complications such as nephropathy in long term. One of the factors of diabetic nephropathy pathogenesis is the increase of oxidant stress. The aim of this study is to examine the effect of quercetin, a powerful antioxidant agent, on renal functions in streptozotocin-induced diabetes mellitus and the change in balance of oxidant-antioxidant capacity in this process. Methods: Five groups of rats were used: Control, DM 8 and 16-week (DM8, DM16), DM 8 and 16-week + quercetin (QUER8, QUER16). Rats in QUER8 and QUER1 6 were treated with IP quercetin (15 mg/kg/day) until the end of the experiment. Results: Malondialdehyte increased in the DM8 and DM16 groups. On the contrary, it decreased in the groups which were given quercetin. Accordingly, increase in NADPH oxidase activity, and decrease in superoxide dismutase and catalase activities in diabetic rats were determined. In the QUER8 and QUER16 groups, NADPH oxidase activity decreased while antioxidant enzyme activities increased. Functional kidney parameters were considerably corrupted in the diabetic rats. Sodium and water excretion via urine and plasma creatinine level in the QUER16 group were lower than in the DM16 group. Conclusion: These findings suggest that the administration of quercetin attenuated renal dysfunction and totally prevented the increase of kidney oxidant damage in DM.
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    Quercetin, a Powerful Antioxidant Bioflavonoid, Prevents Oxidative Damage in Different Tissues of Long-Term Diabetic Rats
    (Galenos Publ House, 2012) Edremitlioglu, Mustafa; Andic, Mehmet Fatih; Korkut, Oguzhan
    Objective: The role of oxidant damage on the development of end-organ injuries caused by diabetic rat is well known. The aim of this study is to examine the effect of quercetin, which is a strong antioxidant bioflavonoid, on oxidant damage and antioxidant capacity in various organs in the case of medium-term or long-term diabetic rat. Material and Methods: Forty-eight male Wistar rats were divided into five groups, namely, control group, diabetic group of 8-weeks, diabetic group of 16-weeks, quercetin treated diabetic group of 8-weeks, and quercetin treated diabetic group of 16-weeks. At the end of the experiment, malondialdehyde levels, superoxide dismutase, catalase, and glutathione peroxidase activities, were measured in the lung, aorta, heart, spleen, liver, and kidney tissues. Results: MDA levels were elevated in all tissues except in the lung in non-treated diabetic groups. Quercetin treatment increased the antioxidant enzyme capacities and considerably reduced oxidant damage. Conclusion: We suggest that quercetin has a protective effect on the aorta, heart, brain, liver, and kidneys from oxidant damage in the case of medium-term or long-term diabetic rat. It can be argued that quercetin is effective by increasing the antioxidant defence capacity in this process.