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    Co-occurrence of Papillary and Follicular Thyroid Carcinoma in a Patient with Hodgkin's Disease
    (Galenos Yayincilik, 2013) Asik, Mehmet; Ozkul, Faruk; Toman, Huseyin; Durmus, Ahmet; Anaforoglu, Inan; Gunes, Fahri; Akbal, Erdem
    [Anstract Not Available]
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    Evaluation of epicardial fat tissue thickness in patients with Hashimoto thyroiditis
    (Wiley-Blackwell, 2013) Asik, Mehmet; Sahin, Sinan; Ozkul, Faruk; Anaforoglu, Inan; Ayhan, Semiha; Karagol, Sukriye; Gunes, Fahri
    Objective Hypothyroidism, whether overt or subclinical, has multiple effects on the cardiovascular system. Epicardial fat tissue (EFT) is closely related to cardiovascular disorders and atherosclerosis. Our study aimed to assess EFT thickness and carotid artery intima-media thickness (CIMT) in patients with Hashimoto's thyroiditis (HT) displaying overt and subclinical hypothyroidism (SCH). Design and patients The study included 33 patients with SCH and 24 patients with overt hypothyroidism (OH) with HT as well as 32 healthy controls. EFT thickness, CIMT, thyroid hormone levels and lipid parameters were measured in all subjects. Correlation analysis and linear regression analysis were performed for EFT thickness. Results Mean EFT thickness was 2.89 +/- 0.38, 3.53 +/- 0.92 and 4.56 +/- 1.61mm in control, SCH and OH groups, respectively (P < 0.001). EFT thickness of OH patients was high compared with SCH and control subjects (P < 0.01 and < 0.001, respectively). CIMT of OH patients was high compared with SCH and control subjects (P < 0.01 and < 0.001, respectively). In addition, EFT was significantly thicker in SCH patients than in controls (P < 0.05). Correlation analysis showed that EFT thickness was significantly positively correlated with CIMT, age, body mass index, systolic blood pressure, thyroid-stimulating hormone, total and LDL cholesterol and triglyceride and negatively correlated with free T4. In the regression analysis, EFT thickness retained its independent and positive association with CIMT, patient group (particularly OH) and systolic blood pressure. Conclusions Epicardial fat tissue thickness may be a useful indicator of early atherosclerosis in SCH and OH patients with HT.
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    The Antibody Response to Endoplasmic Reticulum Stress in Hashimoto's Thyroiditis
    (Galenos Yayincilik, 2013) Asik, Mehmet; Sahin, Mustafa; Anaforoglu, Inan; Arikan, Serap; Haydardedeoglu, Filiz Eksi; Ertugrul, Taner Derun; Tutuncu, Neslihan Bascil
    Purpose: We aimed to investigate the presence of antibodies (Anti-BIP) against binding immunoglobulin protein (BIP), an endoplasmic reticulum (ER) chaperone with immune modulator and anti-apoptotic effects in Hashimoto's thyroiditis (HT) patients. Material and Method: We included sixty-two autoimmune thyroiditis patients, 20 with euthyroid autoimmune thyroiditis, 27 with subclinical hypothyroidism and 15 with hypothyroid, and a control group of 37 healthy subjects. Results: No statistically significant difference was determined in anti-BIP levels among the HT subgroups or in comparison with the control group (p= 0.889). Discussion: Although BIP activation has been shown in vitro in thyroid cells, no difference was determined in our study in anti-BIP levels between the HT patient subgroups and the control group. This suggests that antibodies developing against BIP through apoptosis and/or T cell response are either not related to HT or at levels that cannot be determined by measuring serum.