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    Assessment of genotoxic and cytotoxic effects in COVID-19 patients
    (Cukurova Univ, Fac Medicine, 2025) Aliravci, Isil Deniz; Berber, Ahmet Ali; Kenanoglu, Nihan Akinci; Ertekin, Yusuf Haydar
    Purpose: The objective of our study was to ascertain whether the SARS-CoV-2 virus exerts direct cytotoxic and genotoxic effects on human blood defence cells. Materials and Methods: An in vitro analysis was conducted to assess the cytotoxic and genotoxic effects of the virus using three established tests: the mitotic index (MI), micronucleus (MN), and comet assay (CA). These tests were applied to blood samples from 101 patients. The blood samples were simultaneously analyzed using the polymerase chain reaction (PCR) test. The study population included patients of all ages and genders who presented to the outpatient clinic with symptoms suggestive of a respiratory tract infection and fever. Results: The frequency of MN in the human lymphocytes of COVID-19-infected patients (1.06) was higher compared to COVID-19-negative patients (0.68). Similarly, in COVID-19-positive individuals, parameters such as tail length (3.67), tail moment (1.786), and tail intensity in the comet assay showed a significant increase compared to the negative control, indicating DNA damage. In the cytotoxicity assessment, the MI frequency of COVID-19-positive individuals (0.041) was significantly lower than that of negative controls (0.051). Gender did not influence the cyto/genotoxicity (except for tail length) in SARS-CoV-2-infected patients. Among age groups, the SARS-CoV-2 virus increased MI frequency and tail intensity only in middle-aged individuals (26-36 years). Conclusion: The SARS-CoV-2 virus has the potential to induce cytotoxic and genotoxic effects in the human lymphocytes of infected individuals.
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    Bibliometric Analysis of Human Metapneumovirus Studies
    (Doc Design Informatics Co Ltd, 2023) Aliravci, Isil Deniz; Celik, Taylan; celik-Ekinci, Semiha; Hamidi, Aziz Ahmad
    Objective: This study aimed to estimate research productivity and general characteristics of research in different regions of the world in the field of human metapneumovirus (hMPV). Materials and Methods: We used the Web of Science (WoS) electronic database to retrieve articles on human metapneumovirus, published up to March 31, 2023. Parameters such as research productivity, the total number of publications, average citation counts of all ar-ticles, research productivity by top publishing countries and affiliated organizations, links between countries/organizations, and top keywords were assessed. Results: We found 826 articles in the WoS database. The first article on hMPV was pub-lished in 2002, and 2008 was the year that the most articles on hMPV were published, with 70 articles. The articles were cited 26,797 times (14,498 times without self-citations) and 32.25 times on average per article. Hirsch (H)-index was 80. The year 2008 also had the highest number of citations, with more than 1800. The United States was the most pro-ductive country, producing 295 documents (35.714%), one-third of all publications in this field worldwide. Canada (6.5%) and Japan (6.5%) followed the United States regarding total hMPV publications worldwide. The leading funding agencies for hMPV research were from the United States, Europe, China, and Japan. Conclusion: Our findings imply that developed countries should assist developing countries in enhancing their research infrastructures.
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    Characteristics of health care workers with SARS-CoV-2 at a COVID-19 hospital in Turkiye: Homologous versus heterologous vaccination
    (Professional Medical Publications, 2024) Aliravci, Isil Deniz; Ertekin, Yusuf Haydar; Can, Gamze; Alkan, Sevil
    Objective: Given the limited studies on types of vaccination and infection rates among health care workers (HCWs) in T & uuml;rkiye, we analyzed the demographic, clinical, and vaccination characteristics as well as the attitudes of HCWs who have been infected with COVID-19. Methods: We retrospectively analyzed demographic and clinical data on breakthrough COVID-19 infections in HCWs from hospital surveillance data collected between April 5, 2020, and November 1, 2022. The comparison was based on four subgroups that consisted of unvaccinated, one-shot-vaccinated, homologous vaccinated, and heterologous vaccinated individuals. Participants who received various combinations of Sinovac/CoronaVac and/or BioNTech/Pfizer vaccines were compared for detection of COVID-19. Results: During a 33-month period of 744 HCWs who contracted COVID-19, women (65.3%) and nurses (28.9%) were the most affected, followed by doctors (25.8%). Of the infected HCWs, only 1.3% required hospitalization, 0.3% required ICU support, and 98.4% were outpatients. By vaccination status, 143 of the HCWs (19.2%) were unvaccinated, 292 (39.2%) were homologously vaccinated, 294 (39.5%) were heterologously vaccinated, 15 (2%) received a single shot, 206 (27.7%) received two shots, and 165 (22.2%) received three shots. All HCWs contracted COVID-19 at a mean of 134- days (range:1-539) after vaccination. While the proportions of homologously and heterologously vaccinated HCWs were similar, the time elapsed from vaccination to contracting COVID-19 varied (mean 143.4 +/- 106.7 vs.126.4 +/- 82.43 +/- 82.43 days). Conclusions: Among both outpatients and inpatients with COVID-19, women HCWs outnumbered men HCWs. HCWs who received homologous vaccination contracted COVID-19 later than those who received heterologous vaccination.
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    Deciphering the genotoxic and cytotoxic properties of teicoplanin: a combined laboratory and computational investigation
    (Taylor & Francis Ltd, 2025) Berber, Ahmet Ali; Aliravci, Isil Deniz; Kenanoglu, Nihan Akinci; Demir, Sefika Nur
    In this study, the mutagenicity and carcinogenicity of the teicoplanin antibiotic were first investigated using the Vega Hub and Toxtree software through in silico prediction. The cytotoxic and genotoxic effects were evaluated using in vitro assays, including the mitotic index (MI), micronucleus (MN), nuclear division index (NDI), and Comet Assay (CA) in human lymphocytes. In the in vitro studies, both 24-hour and 48-hour exposures were conducted for MI, and teicoplanin significantly decreased MI compared to the control at all concentrations. In addition, a significant increase was detected in the MN frequency compared to the negative control at all concentrations. In the Comet assay, tail length significantly increased compared to the control at all concentrations except for 5.6 mu g/mL, while tail moment and comet tail intensity significantly increased at all concentrations compared to the control. In conclusion, within the concentration range used in this study, teicoplanin was found to have cytotoxic and genotoxic effects.