Yazar "Alaygut, Demet" seçeneğine göre listele

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    Öğe
    Comparison of two different periods of renal cortical activity ratios in the evaluation of ureteropelvic junction obstruction by dynamic renal scintigraphy
    (2014) Hasbek, Zekiye; Özdemir, Semra; Turgut, Bülent; Erselcan, Taner; Cankorkmaz, Levent; Alaygut, Demet
    Amaç. Retrospektif olan bu çalışmada amacımız, üreteropelvik bileşkede darlığı olan çocuk hastagrubunda, renal sintigrafilerde, 1inci ve 20nci dakikalardan elde edilen kortikal aktivite oranının,obstrüksiyonun varlığının belirlenmesinde takip parametresi olarak kullanılabilirliğiniaraştırmaktır. Yöntem. Çalışmaya toplam 322 renogram dahil edildi. Standart renogram eğrileridiüretiğe verdiği cevaba göre vizüel olarak nonobstrüktif, obstrüktif ve şüpheli olaraksınıflandırıldı. Ayrıca her bir böbrek için 1inci ve 20nci dakikalarda kortikal ROIler çizildi vekortikal sayımlar elde edildi. Bunun dışında renogram ile hesaplanan T 1/2 10 dakikanın altındaolan böbrekler normal, 10-20 dakika indetermine, >20 dakika kötü drenaj olarak kabul edildi.Obstrüksiyon paternleri ile 1inci ve 20nci dakikalardaki kortikal aktivite oranları karşılaştırıldı.Bulgular. Kortikal aktivite sayımlarının oranları ile vizüel olarak belirlenen obstrüktif patern(nonobstrüktif, obstrüktif ve şüpheli) karşılaştırıldığında, Tc-99m DTPA renogramında,1inci/20nci dak. kortikal aktivite oranı %82,8in üzerinde olan hastalar obstrüktif, %59,3 ile%82.8 olan hastalar obstrüksiyon açısından şüpheli olarak bulundu. Tc-99 m MAG-3 ile yapılansintigrafilerde ise, 1inci/20nci dak. kortikal aktivite oranı %74,2nin üzerinde olan hastalarobstrüktif, %44,6 ile %74,2 olan hastalar obstrüksiyon açısından şüpheli olarak bulundu. T½parametresinin böbreklerin obstrüksiyon paterni ile karşılaştırılması sonucunda; vizüeldeğerlendirmeye göre non-obstrüktif olan 299 böbreğin 124ünde (41,5%) T½ indetermine grupta,7sinde (2,3%) ise T½ obstrüktif gruptaydı. Vizüel değerlendirmede şüpheli grupta yer alan 17böbreğin 4ünde (23,5%) T½ normal grupta, 5inde (29,4%) T½ indetermine grupta ve 8inde(47,1%) T½ obstrüktif grupta yer almaktaydı. Sonuç. Biz çocuk hasta grubunda 1inci/20ncidakika kortikal aktivite oranlarının kullanılmasının da obstrüksiyon tanısının konulmasındayardımcı olduğunu düşünmekteyiz.
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    Öğe
    Development of Adolescent Social Media Addiction Scale: study of validity and reliability
    (Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2020) Orbatu, Dilek; Eliacik, Kayi; Alaygut, Demet; Hortu, Hacer; Demircelik, Yavuz; Bolat, Nurullah; Elmali, Ferhan
    Objective: The aim of this study is to build an up to date and easy to use Turkish Social Media Addiction Scale for Adolescents. Methods: The sample of the study included 2020 high school students. The scale was five-point Likert-type and consisted of 13 items. The internal consistency of the items was evaluated with Cronbach's alpha coefficient, summability Tukey summability test, adequacy of the number of units in the sample Kaiser-Meyer-Olkin test, factorability Bartlett test, factor structure main components analysis. Results: Cronbach alfa internal consistency coefficient of the scale was found to be 0.869. The scale consists of three sub-factors: choosing virtual life, impairment in functionality, and virtual pleasure. Total stated variance regarding the scale was 58.89%. Discussion: As a result of this study, a high reliability and validity social media dependency scale was developed. However, it should be kept in mind that all scales developed cannot be valid and reliable in the long term since social media use behaviors in individuals may change over time.
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    Öğe
    Variable phenotype and genotype of pediatric patients with HNF1B nephropathy
    (Dustri-Verlag Dr Karl Feistle, 2024) Gulhan, Bora; Ekici, Ozan; Dursun, Ismail; Goknar, Nilufer; Yuksel, Selcuk; Alaygut, Demet; Ozcakar, Zeynep Birsin
    Aims: Hepatocyte nuclear factor 1 beta ( HNF1B ) mutations are the most common monogenic cause of congenital anomalies of the kidney and urinary tract (CAKUT). We aimed to investigate clinical and genetic characteristics of patients with HNF1B nephropathy to expand its phenotypic and genetic spectrum. Materials and methods: This retrospective cohort study included 16 unrelated pediatric patients (6 females, 10 males) from 13 families with genetically confirmed HNF1B -related nephropathy. Results: Abnormal prenatal kidney abnormalities were present in 13 patients (81.3%). The most common antenatal kidney abnormality was kidney cysts, which were observed in 8 patients (61.5%). Urinary system abnormalities (vesicoureteral reflux (VUR) and ure teropelvic junction obstruction (UPJO)) were present in 4 patients (25%). HNF1B analysis uncovered missense variants in 4 families (30.8%) as the most common genetic abnormality. In addition, 4 novel pathological variations have been defined. During followup, hypomagnesemia and hyperuricemia were observed in 7 (43.8%) and 5 patients (31.3%), respectively. None of the patients with a missense variant had hypomagnesemia. However, 7 out of 12 patients (58.3%) with a non-missense variant had hypomagnesemia (p = 0.09). None of the patients had an HNF1B score below 8, and the mean score was 15.3 +/- 4.4. The mean follow-up period was 7.4 +/- 5.0 years. While 100% of patients (n = 4) with missense variants were in various stages of CKD (CKD2: 2 patients,CKD3: 2 patients), 25% of those with nonmissense variants had CKD (CKD2, 3, and 5; 1 patient, respectively) (p = 0.026). Conclusion: Patients with HNF1B-associated disease have concomitant urinary system abnormalities such as VUR or UPJO. Missense variants seem to be the most common pathological variations in HNF1B gene and have higher risk of CKD.
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    Öğe
    Variable phenotype and genotype of pediatric patients with HNF1B nephropathy [2]
    (Springer, 2024) Gulhan, Bora; Ekici, Ozan; Dursun, Ismail; Goknar, Nilufer; Yuksel, Selcuk; Alaygut, Demet; Ozcakar, Zeynep Birsin
    [No abstract available]