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Öğe Comparison of iodine application methods in rocket plant(Eesti Pollumajandusulikool, 2017) Aksu, G.; Temel, E.; Altay, H.Iodine is an essential trace element for human health and is involved in the production of the thyroid hormone. Recently, a new idea has emerged: to meet people's need for daily iodine by increasing the iodine content of vegetables with high iodine bioavailability and assimilation. This study was carried out with iodine foliar application and root application methods to determine which is more appropriate when attempting to increase iodine content. An experiment was conducted in a greenhouse with 4 doses of iodine in the form of potassium iodide (0, 2, 4, 8 mM), two application methods (foliar and root application) and three replicates. At the end of the experiment, the plants’ fresh and dry weight, relative water content, membrane stability, chlorophyll a, chlorophyll b and total chlorophyll were determined. The results were subjected to analysis of variance according to the randomized blocks experiment design using the MINITAB 17.0 statistical package program. The applications did not show a statistical difference in plant fresh weight and dry weight. There was no statistical difference in the relative water content between the applications, while a statistical difference (P < 0.05) in the membrane stability was observed for the interaction of application type and application dose. Chlorophyll a, chlorophyll b and the total chlorophyll amount were also statistically affected (P < 0.05) by the application doses. Foliar and root application methods have not caused significant loss of yield. Both methods are also considered to be appropriate to use in practice. © 2017, Eesti Pollumajandusulikool. All rights reserved.Öğe Correlation between c-erbB2 expression, lymphovascular invasion and other biological and clinical prognostic factors and preoperative tumor markers in patients with early-stage and locally advanced breast cancer(Zerbinis Medical Publ, 2011) Aksu, G.; Duman, C.; Gurbuz, Y.; Ercin, C.; Canturk, Z.; Utkan, Z.; Dulger, M.Purpose: To evaluate the correlation between c-erbB2 expression, lymphovascular invasion and other biological and clinical prognostic variables and preoperative CA 15-3 and CEA levels in patients with early-stage and locally advanced breast cancer Methods: Preoperative serum concentrations of CA 15-3 and CEA were measured in 123 patients undergoing surgical treatment for stage breast cancer and the association between these markers and clinical and biological variables were evaluated. Results: With cut-off values of 45 U/ml (CA 15-3) and 2.5 ng/ml (CEA), the sensitivity for CA 15-3 and CEA was 10% and 24% and their mean values were 23 U/ml and 2.32 ng/ml, respectively. A significant correlation between preoperative levels of CA 15-3 and CEA was noticed (p=0.023). Preoperative CA 15-3 levels were significantly higher in patients with tumors > 5 cm (p<0.0001), with positive axillary lymph nodes (p=0.04), with increasing nodal burden (p= 0.025) and in patients with stage III disease (p=0.003). Tumor size > 5 cm (p=0.002), increasing axillary nodal burden (p=0.02) and stage Ill disease (p<0.0001) were also significantly correlated with CEA values above the cut-off level. There were no correlations between CA 15-3 and CEA levels and other variables including c-erbB2 expression, age, grade, hormone receptor status, and lymphovascular invasion. Conclusion: Preoperative CA 15-3 and CEA levels are significantly correlated with tumor size, axillaty nodal status and stage in patients with non-metastatic breast carcinoma. No correlation between preoperative values of CA 15-3/CEA and c-erbB2 status, lymphovascular invasion and other prognostic factors was detected.











