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    Exploring the Impact of Wearing-Off Phenomenon in Ocrelizumab-Treated Multiple Sclerosis Patients: Insights from a Comprehensive Study
    (Sage Publications Ltd, 2024) Seferoglu, Meral; Tunc, Abdulkadir; Aksoy, Selma; Sivaci, Ali Ozhan; Uzuner, Gulnur; Mungan, Semra; Inanc, Yilmaz; Yetkin, Mehmet
    [Anstract Not Available]
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    Polysomnographic and Clinical Features of Positional and Non-positional Sleep Apnea Syndrome in Turkish Adult Population: Experience from a Single Institution
    (Springer, 2024) Aksoy, Selma; Çil, Özge Çağlar
    Purpose The purpose of the study is to determine prevalence of positional obstructive sleep apnea (POSA) and non-POSA among obstructive sleep apnea syndrome (OSAS) cases. Additionally, it aims to compare the sociodemographic and polysomnographic characteristics in the city of Canakkale, located in the northwest of Turkey. Method We included 263 patients diagnosed with OSAS by polysomnography (PSG) between January 2021 and November 2022. OSAS was defined as AHI ≥ 5. The severity of OSAS was assessed as normal (AHI < 5); mild (AHI 5–15); moderate (AHI 16–30); and severe (AHI > 30). Sociodemographic characteristics such as gender, weight, and height, along with and polysomnographic features were evaluated and compared between two groups. Results Our final sample was 227 after applying exclusion criteria. The rate of POSA was 48 and 52% of patients had non-POSA. The body mass index (BMI) of the POSA group were significantly lower. Male gender was dominant in both groups. In POSA cases, 25.7% had mild, 38.5% moderate, and 35.8% severe OSA levels. In non-POSA cases, the same ratios were 8.5, 22.9, and 68.6% retrospectively. Positional stage was a risk factor for the severity of AHI score in our study (B = 14.49, p < 0.001, 95% CI 9.66–19.33) according to our analysis. Conclusion We found significant characteristic sociodemographic and polysomnographic features which differentiate these two conditions. Male gender and high BMI constituted considerable risk of severe OSA. Although gender presents an unchangeable risk factor, it has been shown that the most important risk factor for non-POSA is body weight which is a modifiable risk factor.
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    Prevalence of restless legs syndrome: a cross-sectional population-based study from northwest of Turkey
    (Springer Japan, 2021) Aksoy, Selma; Eker, Esen; Yalçın, Sibel; Özışık Karaman, Handan Işın
    Background: Although restless legs syndrome (RLS) is one of the most frequent movement disorders, it is often misdiagnosed or even unrecognized. The aim of this study is to determine the prevalence of RLS among adult population (individuals who are older than 18 years old) in the city center of Canakkale, from northwest of Turkey. Method: This community-based study was performed as a cross-sectional, door-to-door field study.The adult population of the city center of Canakkale had an estimated population of 126,893 according to 2018 data. The sample size of the study assuming RLS prevalence, in Epi Info Statcalc program was determined to be 476 subjects using the sample calculation formula. We reached 622 adults. The International RLS Study Group (IRLSSG) diagnostic criteria were applied and the IRLSSG rating scale (IRLS) was used to assess the severity of symptoms. Results: The RLS prevalence was determined as 12.1%. The prevalence reached peak point (15.3%) in the 50–65-year-old group. The IRLSSG severity scale score correlated with age (r = 0.356, p < 0.01). We observed particularly a higher RLS prevalence for patients with two or more medical comorbidities, although this trend did not reach significance (p > 0.05). Conclusion: We found high prevalence of RLS among adult individuals. Despite this increasing prevalence, very few patients seek professional help and treatment. We see that the prevalence of RLS has increased with recent prevalence studies over the years.
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    Understanding stigma in multiple sclerosis: workplace discrimination, social challenges and psychological impacts
    (Springer Heidelberg, 2025) Bulbul, Nazli Gamze; Tunc, Abdulkadir; Bunul, Sena Destan; Demir, Serkan; Seferoglu, Meral; Sivaci, Ali Ozhan; Aksoy, Selma
    Background Stigmatization in MS patients is an important problem that affects social interaction, work life and daily life. In this study, we investigated the prevalence, severity and especially the effects of stigmatization on work life in MS patients. Methods A cross-sectional study of 420 people living with MS (PwMS) assessed stigma using the NeuroQoL Stigma Short Form and a direct stigma survey. Demographic, clinical, workplace, and social data were collected through an online survey. Statistical analyses were performed.ResultsStigma was prevalent, with 77% reporting stigma in direct surveys and 67.6% scoring > 8 on the NeuroQoL Stigma Short Form. Stigma was more severe in patients with progressive MS and higher EDSS scores. The most disturbing symptoms were fatigue (73.3%), imbalance (46.7%) and attention deficit 50.5%). The most prominent complaint affecting work life was fatigue (41.2%). Only 7.3% of the patients had sought psychological support for this issue. 57.4% of patients had disclosed their illness to their employer and 68.1% to their coworkers.ConclusionsStigma in MS is pervasive, linked to clinical severity, workplace challenges, and social withdrawal. Interventions targeting stigma's psychological and social dimensions, along with workplace education and support are essential.