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    Chronotype and temperament relationship and the effect of chronotype on suicide risk in patients with unipolar depression
    (Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2019) Kilic, Neslihan; Oyekcin, Demet Gulec; Akinci, Erhan
    Objective: The aim of this study was to investigate the relationship between chronotype and temperament in patients with unipolar depression and the effect of chronotype on suicide risk. Methods: The participants consisted of patients with unipolar depression who were eligible for inclusion and exclusion criteria. Subjects were interviewed with the Structured Clinical Interview for DSM-5 and HAM-D, HAM-A scales. Patients filled the Morningness-Eveningness Questionnaire (MEQ), the Pittsburgh Sleep Quality Index, the Suicide Probability Scale and the Temperament Evaluation of Memphis, Pisa, Paris, San Diego Autoquestionnaire. Results: The participants were admitted female (n = 69) and male (n = 19). The rate of past suicide attempts was 24.1%. 50% of the patients had moderate depression and 50% of them had mild depression. According to MEQ scores patients were classified into three groups: 30.7% of them were eveningness, 58% of them were neither (intermediate) and 11.4 % of them were morningness type. The 90.8% of the patients had poor sleep quality. Depressive temperament was the most common temperament in the participants. Chronotype preference was not found to be associated with depression severity, anxiety, suicide probability, sleep quality and temperament characteristics. Discussion: There was not an association between temperament and chronotype preferences. Chonotype preferences do not affect the severity of depression. Chronotype is not a risk factor for suicide. In assessing the risk of suicide in patients with mild to moderate severity depression without comorbid psychiatric disorders; the clinical characteristics of depression should be prioritized by the clinicians, rather than temperament and chronotype.
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    In silico molecular docking and in vitro analysis of atomoxetine
    (Taylor & Francis Ltd, 2025) Bolat, Nurullah; Hiz-celikliyurt, Merve Meliha; Akinci, Erhan; Akkus, Gulsum; Gunay, Melih; Korkmaz, Sukru Alperen
    Although atomoxetine, a selective norepinephrine reuptake inhibitor, is widely used in the treatment of attention-deficit/hyperactivity disorder (ADHD), there is limited data on its cytogenetic effects. This study aimed to investigate the cytotoxicity and genotoxicity of atomoxetine in vivo and silico. Chromosome aberration and micronucleus assays were used to analyze the genotoxic effect of atomoxetine in human peripheral blood lymphocytes under culture conditions. The mitotic index was assessed for cytotoxic potential. For the docking analysis, DNA receptor (1BNA) was prepared with ChimeraX, and the Atomoxetine molecule was optimized by Avogadro2.0 software. In silico molecular docking analysis was carried out utilizing SwissDock online platform. The results obtained were visualized using ChimeraX and Pymol software. Atomoxetine doses of 9.6 mu g/mL (equal to about 1.2 mg/kg as a maintenance dose), 14.4 mu g/mL (equal about to 1.8 mg/kg as the highest dose systematically tested), 48.0 mu g/mL (equal about to 6 mg/kg as five times the maintenance dose) and 96.0 mu g/mL (equal about to 12 mg/kg as ten times the maintenance dose) were analyzed. The findings clearly indicate that atomoxetine has no genotoxic effect at the therapeutic dose. However, we observed genotoxic effects at 48.0 and 96.0 mu g/mL doses. No strong binding affinity occurs in silico analyses. As one of the initial inquiries into the in silico and in vivo appraisal of atomoxetine's genotoxic impacts, the research has established that atomoxetine does not significantly affect the frequency of chromosomal damage or micronucleus formation. Genotoxic effects should be kept in mind at doses above clinical practice.
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    Öğe
    The associations of temperament, character, anxiety, and specialty choice among sixth-year medical students: a cross-sectional study
    (Kare Publ, 2020) Akinci, Erhan
    Objective: This study aimed to investigate the effects of anxiety, temperament, and character dimensions on the preferences of final-year medical students for postgraduate education. Method: Participants were 161 students in a sixth-year medical class. The primary outcome variables of the study were the preferred main specialty category and branch. Independent study variables were age, gender, perception of the economic situation, place of birth, and State-Trait Anxiety Inventory and Temperament and Character Inventory scores. Results for 151 participants were analyzed. Results: The mean (+/- SD) age of the participants was 23.66 +/- 1.18 years, and 57.6% (n=87) were females. The participants stated that they would choose mostly internal (64.2%, n=97) and surgical (35.1%, n=53) disciplines, while the basic sciences were the least favored (0.7%, n=1). The most popular specialties were psychiatry (9.9%, n=15), orthopedics and traumatology (8.6%, n=13), and physical therapy and rehabilitation (8.6%, n=13). There was no significant difference between state (chi(2)=1.93, p=0.382) and trait (chi(2)=2.31, p=0.315) anxiety levels and the specialty category selections. Harm avoidance (HA), fear of uncertainty (HA2), shyness (HA3), fatigability (HA4), and sentimentality (RD1) scores of students opting for internal medicine were statistically higher than scores for surgical sciences (p<0.05). In addition, the resourcefulness (SD3) scores of the aspiring internists were statistically lower than scores for surgery (p<0.05). Conclusion: Temperament and character have some degree of influence on the choice of specialty, whereas anxiety was shown not to have such an impact. These findings may be helpful to medical educators or career counselors in the specialty choice of medical students.