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Öğe Medical Image: Silicosis due to denim sandblasting: Multidetector CT findings(2008) Akgun, Metin; Kantarci, Mecit; Araz, Omer; Ucar, Elif Yilmazel; Mirici, Arzu[No abstract available]Öğe Silicosis due to denim sandblasting: multidetector CT findings(New Zealand Medical Assoc, 2008) Akgun, Metin; Kantarci, Mecit; Araz, Omer; Ucar, Elif Yilmazel; Mirici, Arzu[Anstract Not Available]Öğe Steroids in acute exacerbations of chronic obstructive pulmonary disease: are nebulized and systemic forms comparable?(Lippincott Williams & Wilkins, 2009) Gunen, Hakan; Mirici, Arzu; Meral, Mehmet; Akgun, MetinPurpose of review Systemic corticosteroids are strongly recommended in the treatment of exacerbations of chronic obstructive pulmonary disease (COPD). As COPD patients are usually elderly and are relatively immobile, side effects of systemic corticosteroids frequently outweigh their beneficial effects. On the contrary, nebulized corticosteroid solutions have a negligible systemic side-effect profile. In this review, as an alternative to systemic corticosteroids, the place of nebulized corticosteroids in exacerbation periods of COPD was summarized. Recent findings The number of trials in the literature is increasing. Regarding the available data, high dose nebulized budesonide was found as effective as systemic corticosteroids in exacerbations of COPD. The side-effect profile, blood glucose level in particular, is better for nebulized budesonide. Summary Findings from recent studies are giving a positive impression on the role of high dose nebulized budesonide in exacerbations of COPD. However, larger and statistically high powered trials testing different types of nebulized corticosteroid solutions with varying dosages are still lacking. Before recommending the routine use of nebulized corticosteroids in exacerbations, present findings need to be confirmed with further studies of high quality.Öğe The diagnostic value of bronchoscopy in smear negative cases with pulmonary tuberculosis(Turkish Assoc Tuberculosis & Thorax, 2008) Araz, Omer; Akgun, Metin; Saglam, Leyla; Ozden, Kemalettin; Mirici, ArzuThere are many studies showing usefulness of bronchoscopy in patients with suspected pulmonary tuberculosis (Tbc) and negative sputum smear. However, there is no enough data concerning that in which cases bronchoscopy is more useful. We aimed to investigate in which cases bronchoscopy is more diagnostic and also an in which cases presence of endobronchial involvement is more likely. A total of 60 smear negative patients undergoing bronchoscopy due to tuberculosis suspicion were evaluated. The characteristics of cases with or without positive diagnosis via bronchoscopy and also of the ones with or without endobronchial involvement were compared. Bronchoscopy provided positive result for Tbc in 29 (76%) of 38 cases with confirmed as Tbc later and 7 (18%) cases had endobronchial involvement. In the cases who are diagnosed as Tbc via bronchoscopy, the mean serum levels of C-reactive protein (CRP) were significantly higher than those of undiagnosed (p< 0.05). In the cases with endobronchial involvement, the duration of symptoms was significantly shorter (p= 0.01); the diameter of tuberculin skin test induration was significantly smaller (p< 0.05); and mean serum level of CRP was significantly higher (p< 0.05) than those of without endobronchial lesion. The results suggest that it is more likely to diagnose Tbc bronchoscopically in the cases who had increased serum levels of CRP, and possibility of endobronchial involvement may be increased among the cases in active and earlier period of the disease. However, further studies are required to support this hypothesis.
