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Öğe A Comprehensive Bibliometric Analysis on Neuronavigation Researches(Pera Yayincilik Hizmetleri, 2023) Akar, AliObjective: Neuronavigation is a novel method that has made great advances in the field of neurosurgery. The aim of this study was to review the published literature on this topic and to investigate the current state of research and trending topics. Methods: A bibliometric analysis of the neuronavigation on the Web of Science database was performed. The publications included in the study were analyzed with Bibliosiny, bibliometrix (version R 4.2.2), and the Literature Metrology Online Analysis Platform. Graphs from Web of Science were also utilized and some tables were created with the help of Excel. Results: The current study included 3026 research articles on neuronavigation. 11040 authors, 2332 affiliations, and 93 countries contributed to the literature on neuronavigation. The earliest publications on neuronavigation were published in early 1990. The first article was published in Germany. The international co-authorship rate was 17.78%. Most of the international co-authorship was between the United States and Germany. Conclusion: Neuronavigation research will remain a hot topic as technology advances. As a result, this study presented the trend and characteristics of neuronavigation studies, offering researchers a useful bibliometric analysis for future research.Öğe A visual and bibliometric analysis of Parkinson’s disease biomarker research(2023) Cinpolat, Havva Yasemin; Akar, AliAim: Biomarker research in Parkinson’s lacks a systematic bibliometric review, despite a growing body of bibliometric studies. This study aimed to analyze publications on biomarkers that may play an important role in the diagnosis and treatment of Parkinson’s disease. Materials and Methods: In the study, bibliometric methods were used to analyze the related research in depth. Data were obtained from the Web of Science Core Collection database. Specific keywords consisting of MeSH terms were used as search criteria. The search was conducted in English and the type of publication was selected as article. Microsoft Excel, VOS viewer and the visualization and analytical capabilities of the Biblioshiny R package were used in the analysis, providing a versatile approach to achieve the study objectives. Results: A total of 461 articles on Parkinson’s disease biomarkers published between 2002 and 2023 in 170 journals met the criteria and were analyzed. Regarding publications and citations, the year 2022 stood out. Each document had an average of 6.28 co-authors. The main contributing countries were the United States, China and Italy, with a global co-authorship rate of 30.8%. Notable institutions included the University of Washington, Ruhr University Bochum and the Paracelsus Elena Clinic. \"Journal of Neurochemistry,\" was the journal with the most publications. Through their total link strength, prominent terms such as \"Parkinson’s disease\", \"biomarker\" and \"alpha-synuclein\" showed significant occurrences and thematic relevance. Conclusion: The present study presents the inaugural bibliometric evaluation of biomarkers in Parkinson’s disease. The gradual increase of papers since 2012 indicates persistent scholarly interest and foretells continued significance over the following ten years. Future research will be aided by the study’s depiction of biomarker patterns, which provides insightful information. The term \"Alpha-synuclein\" stood out, highlighting its relevance in our research.Öğe BIBLIOMETRIC ANALYSIS ON DEEP BRAIN STIMULATION PROCEDURES CONDUCTED BETWEEN 2000-2023(Galenos Publ House, 2024) Cakir, Murteza; Akar, AliObjective: Deep brain stimulation (DBS) is a treatment method that uses electrodes to stimulate the brain, affecting brain activity and potentially causing medical conditions. It is commonly used to treat Parkinson's disease, essential tremor, dystonia, epilepsy, Tourette syndrome, and obsessive-compulsive disorder. This bibliometric study examines advanced bibliometric parameters in articles published since 2000, focusing on trends in publishing organizations, countries, funding sources, international collaborations, and trend keywords. Materials and Methods: We have searched the Web of Science database to find articles on DBS which published since 2000. The search was performed by using the MESH keywords releated to Deep brain stimulation. Results: This study presents a comprehensive analysis of 4,601 articles on Deep Brain Stimulation (DBS) from 2000 to 2023, focusing on publication trends, properties, funding, country contributions, and international collaborations. Noteworthy findings include a peak of 413 publications in 2020 and 14,992 citations in 2021. The overall trajectory demonstrates a significant increase in scientific output, with an average of 31.9 citations per article. Publication properties reveal diverse access categories, including 66 Early Access and 2,136 Open Access articles. The majority of records are in the Science Citation Index Expanded (93.980%). Clinical Neurology dominates research topics with 63.464% representation. Funding sources highlight major contributions from the USA, Germany, and China. The USA leads in research output, while the University of Toronto tops institutions. Major journals include Stereotactic and Functional Neurosurgery and Movement Disorders. Keyword analysis emphasizes common themes like deep brain stimulation and Parkinson's disease. International collaborations involve researchers from 75 countries, with the USA leading in total link strength. This study contributes valuable insights into the global landscape of DBS research. Conclusion: This analysis highlights the dynamic nature of Deep Brain Stimulation research, highlighting global collaboration and diverse topics, emphasizing the crucial role of key countries, institutions, and journals.Öğe Correlation between the Tuffier's Line and the Spinopelvic Parameters(Cem TIRINK, 2023) Akar, Ali; Malçok, Ümit AliTuffier’s line (TL) is a horizontal line that connects the two superior iliac crests and is used to determine L4 and L5 vertebrae levels. Spinopelvic parameters have been gaining further importance in the diagnosis and treatment planning of spinal diseases. This study aims to reveal whether there is an interaction between TL and spinopelvic parameters. We examined the 113 patients who consulted our clinic for low back pains. TL levels were divided into five categories as L4 body, L4 inferior endplate, L4-5 disc space, L5 superior endplate, and L5 body. In the study group, 70 of the cases (61.9%) were female, 43 (38.1%) were male, and the average age was 50.8 (21–77). TL was determined to pass through L4 body in 38.9% of cases (n=44) regardless of gender. It was observed that sacral slope (SS) and lumbar lordosis (LL) were affected by the changes in TL level (P0.05). SS and LL being affected by changes in TL levels indicates that TL should be assessed together with the spinopelvic parameters. To conclude, TL is a potential spinal parameter that should be included in the spinopelvic parametersÖğe Distribution of Lumbar Microdiscectomy Cases by Tuffier’s Line Levels(2023) Akar, Ali; Malçok, Ümit AliObjective: The most used method in the surgical treatment of lumbar disc herniation (LDH) is lumbar microdiscectomy (LMD). In this study, we aimed to show the relationship between Tuffier's line (TL), which is widely used in determining the L4-5 distance in lumbar spinal interventions, and LMD levels. Materials and Methods: In this study, a total of 204 patients who had LMD or had low back pain were reviewed retrospectively. According to the projection of TL at the spine level; it was divided into 5 categories as L4 corpus, L4 lower endplate, L4-5 disc space, L5 upper endplate, L5 corpus. The cases were analyzed according to age, gender, disc level and changes in TL. Results: 92.1% of the cases were operated at the L4-5 or L5-S1 level. TL was mostly at L5 upper endplate level in women, L4-5 disc space and above in men, and there was a significant relationship between TLs and gender in both groups (p<0.05). Conclusion: In our study, we found that although TLs were caudally in patients operated at L5-S1 level, they displaced cranially in patients operated at L4-5 level. However, it was observed that LDH development in the lower lumbar region and increased at the upper levels with ageing.Öğe Distribution of Traumatic Spinal Injuries in Turkey In Accordance with ICD-10 Codes between the Years 2015 and 2019(Eskişehir Şehir Hastanesi, 2021) Malçok, Ümit Ali; Akar, AliIntroduction: The incidence of traumatic spinal injuries (TSIs) is increasing around the world, our country included. In this study, the distribution of ICD-10 codes used after TSI examinations in Turkey and specifically in Çanakkale between the years 2015 and 2019, and their changes throughout the years were analyzed. Methods: Nationwide data of Turkey and data of Çanakkale province were obtained from relevant institutions and open access statistics reports. Anatomical regions, types of injury and annual changes in ICD-10 codes of TSI examinations were analyzed. Results: Across Turkey, the number of medical examinations increased by 18% in secondary and tertiary care facilities between the years 2015 and 2019. For TSI examinations, the increase was 61%. In Çanakkale province, the number of medical examinations increased by 13.4% and TSI examinations by 9% in this 5-year period. Across Turkey, S33 (919.868) was the most used code in TSI examinations in these 5 years. The least used code was S24 (3.951). In Çanakkale province, it was determined that the code S22 (6508) was used the most, and S24 (23) was used the least. Conclusion: It was determined that TSI examinations across Turkey increased by 61% in this 5-year period, and the lumbar region was the most effected. The neural injury rate was high in the cervical region, despite TSI being relatively less common. There was a significant difference between Çanakkale province and Turkey when the ICD code ratios in spinal region were compared. We can conclude from this difference that clinicians use different ICD-10 codes for the same disease. In conclusion, we believe that it should be confirmed that ICD-10 codes actually match the patient's diagnosis in epidemiological studies to be conductedÖğe EFFECTS OF LUMBAR MICRODISCECTOMY ON SPINOPELVIC PARAMETERS(Turkish Spine Society, 2021) Malçok, Ümit Ali; Akar, AliObjective: One of the causes which accelerates spinal degeneration process is lumbar disc hernia (LDH). In this study, we observed the changes in spinopelvic parameters one month after single-level lumbar microdiscectomy (LM). Materials and Methods: Standardized bilateral standing scoliosis radiography images of 19 patients, which were performed before and 1 month after LM operation, were evaluated retrospectively. Sagittal vertical axis and coronal vertical axis distances, thoracic kyphosis, lumbar lordosis, pelvic incidence, sacral slope and pelvic tilt angles were measured with Surgimap software. Results: There was a positive correlation between pre-and post-LM values of all spinopelvic parameters included in the study. In comparative tests however, the difference was found to be not statistically significant. As a result, despite LM operation slightly improved spinopelvic parameters in the first month, there was not a significant change overall. Conclusion: LDH is known to worsen the degenerative process in spine. LM as a treatment option is seen to alleviate this degenerative process by slowing down the deterioration in spinopelvic parameters.Öğe Evaluation of Publications on Pineal Tumor from a Bibliometric Perspective(Cem TIRINK, 2023) Akar, AliThere are still many unknowns about the classification, diagnosis, and treatment of pineal tumors. The aim of this study was to review the accumulated knowledge of pineal tumors to guide future research. Web of Science (WoS) Core Collection was used to access the articles, and the Vosviewer package program was used for visualizations. The results showed that, between 1970 and December 2022, the WoS database indexed 1103 publications and 668 articles on pineal tumors. 92,365% of the articles were published in journals within the scope of the Science Citation Index Expanded. 798 institutions and 2,841 authors contributed to the pineal tumors literature. The most important contributions to the literature on pineal tumors were made by institutions in France and the United States. The majority of the articles were from the USA (n=190, 28.443%), Japan (n=111, 16.617%), and France (n=62, 9.281%). The number of articles were irregular in each per year. However, more citations have been made, especially since 2010. In this study, the studies on pineal tumors in the world were examined and the main underlied issues were tried to be emphasized. In addition, it has been observed that the scientific and industrial sectors should cooperate in order to increase the allocated resources for multidisciplinary researchesÖğe Investigation of Venous Thromboembolism Prophylaxis Practices in Spinal Fusion Surgery and Outcomes: A Single Center Experience(Rabia YILMAZ, 2023) Akar, Ali; Şahin, SerpilAbstract Aim: Venous thromboembolism (VTE) is among the most common causes of preventable hospital-acquired deaths. VTE is known as deep vein thrombosis (DVT) when it occurs in the veins and pulmonary embolism (PE) when it occurs in the lungs and is common in surgery practice. We aimed to determine the frequency of venous thromboembolism (VTE), the factors affecting the development of VTE, and the types and effectiveness of VTE prophylaxis applications in patients who underwent spinal fusion surgery (SFS). Material and Methods: The patients aged over 18 who underwent SFS for spinal fracture or thoracolumbar stenosis in our neurosurgery clinic between June, 2020 and December, 2022 were included. The patients records were evaluated retrospectively. VTE prophylaxis was given according to the Caprini risk score. Results: A total of 137 patients, 85 (62%) of female, with a meanage of 48.6±+8.77 years were included in the study. According to the Caprini risk scores, 90 (65.7%) of the cases were at high risk. VTE was detected in four patients (2.9%) despite prophylaxis (3 cases of DVT and one pulmonary embolism). Conclusions: Although VTE prophylaxis is performed according to Carpini risk score in SFS, it is seen that embolisms cannot be prevented sufficiently. Therefore, studies with a high level of evidence are needed for the use of these algorithms in SFSÖğe Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage(Springer, 2023) Akar, Ali; Öztopuz, Rahime Özlem; Büyük, Başak; Ovalı, Mehmet Akif; Aykora, Damla; Malçok, Ümit AliSubarachnoid hemorrhage (SAH) accounts for 5% of all stroke cases and is responsible for significant permanent brain and neurological damage within the first few days. Loss of smell is one of those neurological disorders following olfactory bulb injury after SAH. Olfaction plays a critical role in several aspects of life. The primary underlying mechanism of olfactory bulb (OB) injury and loss of smell after SAH remains unknown. Piceatannol (PIC), a natural stilbene, possesses anti-inflammatory and anti-apoptotic effects against various diseases. In this study, we aimed to investigate the potential therapeutic effects of PIC on OB injury following SAH at molecular mechanism based on SIRT1, inflammatory (TNF-α, IL1-β, NF-κB, IL–6, TLR4), and apoptosis (p53, Bax, Bcl-2, caspase-3)-related gene expression markers and histopathology level; 27 male Wistar Albino rats were used in a pre-chiasmatic subarachnoid hemorrhage model. Animals were divided into groups (n = 9): SHAM, SAH, and PIC. Garcia’s neurological examination, brain water content, RT-PCR, histopathology, and TUNEL analyses were performed in all experimental groups with OB samples. Our results indicated that PIC administration significantly suppressed inflammatory molecules (TNF-α, IL–6, IL1-β, TLR4, NF-κB, SIRT1) and apoptotic molecules (caspase-3, p53, Bax). We also evaluated edema levels and cell damage in OB injury after SAH. Ameliorative effects of PIC are also observed at the histopathology level. Garcia’s neurological score test performed a neurological assessment. This study is the first to demonstrate the neuroprotective effects of PIC on OB injury after SAH. It suggests that PIC would be a potential therapeutic agent for alleviating OB injury after SAH.Öğe Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage (Mar, 10.1007/s12035-023-03306-x, 2023)(Springer, 2023) Akar, Ali; Oztopuz, Rahime Ozlem; Buyuk, Basak; Ovali, Mehmet Akif; Aykora, Damla; Malcok, Umit Ali[Anstract Not Available]Öğe Osteoporotik Vertebra Kırıklarının Retrospektif Analizi(2023) Akar, AliAmaç: Osteoporotik vertebra kırığı (OPVK) ileri yaşlarda oldukça sık görülen patolojilerdir. Bu çalışma ile OPVK hastaların, osteoporoz (OP) düzeyleri ve tedavi alışkanlıkları ile OPVK nedenleri ve tedavi şekilleri arasındaki ilişkiyi ortaya koymayı amaçladık. Araçlar ve Yöntem: OPVK nedeni tedavi edilen 50 yaş üzeri 65 olgu retrospektif olarak incelendi. Hastaların müracaatları esnasında OP tanısı (var-yok) ve tedavileri (var-yok) olup olmadığına göre ayrıldı. OPVK tedavisi esnasındaki DEXA sonuçlarına göre hastalar osteopeni (T skoru -1 ve -2.5 arası) ve OP (T skoru<-2.5) olarak iki gruba ayrıldı. OPVK nedenlerine göre trafik kazası, düşme ve travma yok ve tedavi şekillerine göre medikal, kifoplasti ve posterior stabilizasyon olarak 3 gruba ayrıldı. Bulgular: Hastaların OPVK nedeni ile kliniğimize müracaatı esnasında hiçbirinde OP tanısının olmadığı, dolayısı ile OP medikal tedavisi almadığı görüldü. Kadın ve erkek cinsiyet arasında DEXA değerlerinde anlamlı bir fark olduğu tespit edildi (p=0.045). Yaş kategorisi ve OPVK nedenleri ile DEXA değerlerinin arasında anlamlı bir ilişki yoktu (p=0.144, p=0.163). Sonuç: Osteoporoz ve OPVK yaşam süresi uzadıkça giderek daha büyük ve daha önemli bir halk sağlığı sorunu haline gelmektedir. OPVK’dan korunmak için, OP’nin erken tanı ve tedavisi önemlidir. OP ve tarama yöntemleri için farkındalığın arttırılması gerekmektedir.Öğe Perkütan Diskektomi Üzerine Bir Bibliyometrik Analiz Çalışması(Rabia YILMAZ, 2023) Akar, AliÖz Amaç: Perkütan diskektomi beyin cerrahisi alanında önemli bir konudur. Ancak bu konudaki bilimsel yayınların çıktıları bilinmemektedir. Bu çalışmanın amacı perkütan diskektomi ile ilgili 1970 yılından beri yayınlanan orijinal bilimsel çalışmaların bibliyometrik analizini yaparak bilgi birikimine katkıda bulunmaktır. Gereç ve Yöntem: Literatür taraması Web of Science veri tabanı kullanılarak yapılmıştır. Perkütan diskektomi ile ilgili Mesh anahtar kelimelerini içeren tüm makaleler ve alıntıları, arama motorunun "başlık" bölümünden aratıldı. Ülkelerin ürettikleri makale sayısı ve gelişmişlik göstergeleri analiz edilmiştir. Makalelerin ortak yazarlığını, anahtar kelimelerini vb. Haritalamak için Vosviewer programından yararlanıldı. Bulgular: 1983-2021 yılları arasında 619 makale bulundu. İlk makaleler 1983 yılında yayınlanmıştı (3 makale). Makalelerin yaklaşık %73'ü 2000 yılından beri yayınlanmıştı. Perkütan diskektomi konusunda lider ülke Çin Halk Cumhuriyeti idi (n=264, %42.649). Çin, Güney Kore, Amerika Birleşik Devletleri, Japonya ve Almanya'dan gelen yazarlar en üretken yazarlar idi. Çin'den yayınlanan yayınlara 2237 (makale başına 8,47), Güney Kore'den yayınlanan yayınlara 3483 (makale başına 34,49) atıf yapılmıştı. Wooridul Spine Hospital (Güney Kore) en çok yayın yapan kuruluştu. Sonuç: Perkütan diskektomi ile ilgili gelecekteki araştırmalar, bu bibliyometrik çalışmada toplanan verilerden yararlanabilecektir. Nöroşirürji alanındaki yayınların çeşitliliği, en gelişmiş ülkelerde coğrafi olarak artmaya devam etmiştir. Gelişmiş ve gelişmekte olan ülkeler arasındaki yayın oranlarındaki eşitsizlik aynı zamanda sabit kalmıştırÖğe Rarely Seen Intradiploic Skull Hematoma in Infants(Lippincott, Williams & Wilkins, 2021) Malçok, Ümit Ali; Akar, AliAlthough the first intradiploic hematoma (IH) case was reported in 1934, only 7 infant cases were reported in the literature. The authors present 2 IH cases, without birth trauma or bleeding disorder, which were treated surgically. IH is also included in the differential diagnosis of babies with a skull deformity. Computed tomography and magnetic resonance imaging modalities should be used together in diagnosis and treatment. The authors believe that the surgery to treat skull deformity because of IH in babies should be planned in the early period.Öğe THE UTILITY OF HEMATOLOGICAL INDICES AT THE INITIAL ADMISSION TO THE NEUROSURGERY CLINIC IN CERVICAL DISC HERNIATION(Galenos Publ House, 2024) Cinpolat, Havva Yasemin; Akar, Ali; Malcok, Umit Ali; Alkan, SevilObjective: This study aimed to investigate hematological indices to predict spontaneous regression in patients with cervical disc herniation (CDH) during the initial visit to outpatient clinics. Materials and Methods: This retrospective study was carried out at a single center by reviewing laboratory parameters to assess the outcomes of CDH patients. The cohort consisted of patients with CDH who had undergone surgery, those who had undergone conservative treatment and achieved spontaneous regression, and a control group without CDH. The laboratory data consisted of the neutrophil-tolymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammatory index (SIII). Results: Differences in the NLR, MLR, and SIII were statistically significant across groups (p<0.001). Compared with the spontaneous regression and control groups, the surgical intervention group presented significantly greater NLR, MLR, and SIII values. According to the comparison of the patients with CDH in terms of the level of herniation, there were no significant differences at the C4-C5 and upper levels, whereas there was a statistically significant increase in the NLR, MLR, and SIII in the surgical intervention group compared with the spontaneous regression group at the C6-C7 level (p = 0.015, p<0.001, and p = 0.003, respectively). Conclusion: This study provides valuable insights into the use of hematological indices to predict the need for surgical intervention in CDH patients. The observed associations emphasize their practical use, providing a way for further research and their inclusion in routine diagnostic protocols for CDH management.
