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    A new organ preservation solution for static cold storage of the liver. Amniotic fluid
    (Acta Cirurgica Brasileira, 2019) Buyuk, Basak; Demirci, Tuba; Adali, Yasemen; Eroglu, Huseyin Avni
    Purpose: To evaluate the effect of amniotic fluid in liver preservation in organ transplantation, and compare it with standard preservation solutions. Methods: The groups consisted of Group 1: Ringer Lactate (RL) group, Group 2: HTK group, Group 3: UW group, Group 4: AF group. The livers of rats from Group 1, 2, 3, and 4 were perfused and placed into falcon tubes containing RL, HTK, UW, and AF solutions at +4(sic)degrees C, respectively. The tubes were stored for 12 hours in the refrigerator at +4 degrees C. Tissue samples were taken at the 6th and 12th hours for histopathological examinations of the perfused livers, and storage solutions for biochemical analyzes at 6th and 12th hours. Results: AF was shown to maintain organ viability by reducing the number of cells undergoing apoptosis. Histopathological changes such as sinusoidal dilatation, hydropic degeneration, and focal necrosis were found to be similar to the groups in which the standard organ preservation solutions were used. Additionally, the results of INOS, IL-10, and TNF-alpha, which were evaluated immunohistochemically, have been shown to be similar to the UW and HTK groups. Conclusions: AF provided conservation similar to UW and HTK in the 12-hour liver SCS process. The fact that apoptosis values are comparable to standard preservation solutions supports the success of AF in the cold storage of the liver.
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    An experimental study of ascorbic acid effects in acute renal failure under general anesthesia
    (Acta Cirurgica Brasileira, 2017) Ozturk, Omur; Ustebay, Sefer; Eroglu, Huseyin Avni; Gunay, Murat; Adali, Yasemen; Donmez, Ilksen; Erbas, Mesut
    Purpose: To evaluate the preventive effect of ascorbic acid on sevoflurane-induced acute renal failure in an experimental rat model. Methods: Twenty-four adult male Wistar rats were randomly distributed into three groups. Subjects were allocated into 3 groups: Group I received sevoflurane only, whereas Groups II and III had moderate (150 mg/kg) and high (300 mg/kg) doses of AA in addition to sevoflurane, respectively. Rhabdomyolysis and myohemoglobinuric ARF was formed by intramuscular administration of glycerol on the upper hind limb on the 15th minute of inhalation anesthesia. Biochemical parameters consisted of serum levels of blood urea nitrogen, creatinine, neutrophil gelatinase-associated lipocalin (NGAL), total antioxidant capacity (TAC), and protein carbonyl content. Histopathological variables were tubular necrosis, fibrin, and cast formation. Results: NGAL levels were significantly lower in Group III than Group II and Group I. On the other hand, TAC, PCO, urea and creatinine levels were notably higher in Group I compared with Groups II and III. There was a significant difference between 3 groups on frequencies of acute tubular necrosis (p=0.003), fibrin (p<0.001) and cast (p<0.001). Acute tubular necrosis and fibrin formation were more prominent in Group I. Casts were more common in Groups II and III. Conclusions: The ascorbic acid serve as a prophylactic agent against renal damage in patients receiving sevoflurane anesthesia and higher doses were associated with more apparent protective effects.
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    An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy
    (Acta Cirurgica Brasileira, 2018) Ozturk, Omur; Eroglu, Huseyin Avni; Ustebay, Sefer; Kuzucu, Mehmet; Adali, Yasemen
    Purpose: To compare the preventive effects of N-acetyl cysteine (NAC), ozone preconditioning and ozone treatment against contrast-induced nephropathy (CIN) in an experimental rat model. Methods: Thirty adult male Wistar rats were randomly distributed into five groups (n=6 for each group). Group I served as control and Group II had only contrast agent, while Group III received NAC and Group IV received Intraperitoneal ozone 6 hours before and 6 hours after Introduction of contrast agent. Ozone treatment was applied for 5 days after the contrast agent was Introduced in Group V. After induction of CIN, groups were compared in terms of serum levels of urea, creatinine, neutrophil gelatinase associated lipocalin, protein carbonyl, total antioxidant capacity (TAC) as well as degree of renal Injury at histopathologic level. Results: Groups II-V displayed more obvious histopathological alterations such as hemorrhage and renal tubular Injury compared with Group I. TAC(p=0.043) and creatinine (p=0.046) levels Increased significantly in Group II after the intervention. In Group III, protein carbonyl level diminished remarkably (p=0.046), while creatinine level was increased (p=0.046) following the intervention. TAC level was higher in Group IV (p=0.028) and Group V (p=0.026) following the procedure. Conclusion: The N-acetyl cysteine and ozone treatment may alleviate the biochemical and histopathological deleterious effects of contrast-induced nephropathy via enhancement of total antioxidant capacity and decreasing oxidative stress.
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    Association of Histopathology and Hemogram Findings Following Sleeve Gastrectomy
    (Mary Ann Liebert, Inc, 2019) Eroglu, Huseyin Avni; Adali, Yasemen; Beseren, Hatice; Guvendi, Gulname Findik; Binnetoglu, Kenan
    Objectives: This study aimed to evaluate the effects of histopathological findings observed in removed gastric tissues on the preoperative and postoperative hemogram data. Materials and Methods: Sixty patients with sleeve gastrectomy were included in the study. Histopathologic findings were compared with the hemogram values. Results: Preoperative hemoglobin (HGB) and hematocrit (HCT) values were significantly lower in patients with intestinal metaplasia (IM) compared to those without IM (p values 0.033 and 0.036, respectively). Preoperative red blood cell (RBC) and HCT values were significantly lower in women with Helicobacter pylori compared with those without H. pylori (p values 0.031 and 0.032, respectively). In contrast, in men with H. pylori, the preoperative RBC, HGB, and HCT values were significantly higher than those without H. pylori (p values 0.007, 0.031, and 0.027, respectively). Conclusion: We found that IM and presence of H. pylori had effects on hemogram values. We suggest that preoperative H. pylori assessment can yield use in the evaluation of postoperative anemia.
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    CAN AMNIOTIC FLUID BE AN ALTERNATIVE ORGAN PRESERVATION SOLUTION FOR COLD RENAL STORAGE?
    (Asoc Regional Dialisis Trasplantes Renales, 2020) Buyuk, Basak; Demirci, Tuba; Adali, Yasemen; Eroglu, Huseyin Avni
    Introduction: Kidney-transplantation is a life-saving treatment option for patients with chronic renal failure. Preserving the viability of the organ from the removal of the organ until transplantation into the recipient is one of the most essential factors affecting postransplant success. Kidney tissue is exposed to ischemia following removal of the organ from the donor, initiating some cellular events. Amniotic fluid (AF) was previously reported as a preservation solution for the liver, but not for the kidney yet. The aim of this study is to investigate the effectiveness of AF as a preserving solution for rat kidneys compared with the University of Wisconsin (UW) and Histidine-Tryptophan-Ketoglutarate (HTK), which are reported to be the most commonly used and preferred preserving solutions. Methods: Forty male Wistar albino rats were used in this study in four experimental groups. Group 1: Ringer Lactate (RL, Control) group, Group 2: HTK group, Group 3: UW group, and Group 4: AF group. A midline incision was performed, and the renal artery was isolated under ketamine and xylazine anesthesia. Solutions relevant for groups (cooled to + 4 degrees C) were used for kidney perfusion. Nephrectomy was applied, and the removed kidneys were placed into + 4 degrees C standard organ storage solution and stored at + 4 degrees C for 12 hours. After 12 hours of storage, samples from the kidney tissues were fixed in 10% neutral buffered formalin. Histopathological, immunohistochemistry evaluation and apoptosis detection via TUNEL method were performed. Results: The results of the AF group were close to those of the UW and HTK groups. Tubular necrosis and vacuolization were high in the RL solution group when compared to the other experimental groups. Immunohistochemistry staining for all three markers (TNF-alpha, IL-18, and iNOS) was decreased in the amniotic fluid group, similar to the UW and HTK groups. Also, the number of apoptotic cells was decreased in the AF group compared to control. Conclusions: UW, HTK, and AF had similar and higher protective effects compared to the RL solution. Thus, AF may be used as an inexpensive and readily available alternative natural tissue preservation solution.
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    Comparison of tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model
    (Assoc Medica Brasileira, 2020) Adali, Yasemen; Eroglu, Huseyin Avni; Makav, Mustafa; Karayol, Sunay Sibel; Guvendi, Gulname Findik; Gok, Mustafa
    INTRODUCTION: Liver biopsies such as tru-cut (sharp needle) and fine-needle aspiration cytology (FNAC) are the most commonly preferred techniques to detect the grade and stage of certain liver diseases. In this study, we aimed to compare the efficiency of USG-guided tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model. METHODS: Thirty-six female Wistar albino rats, 4-6 months old, and weighing from 190 to 250 g, were used in this study. The animals were randomly divided into six equal groups: GI (control), G2 (tru-cut control), G3 (FNAC control), G4 (Alcoholic liver disease model), G5 (Alcoholic liver disease model + FNAC), and G6 (Alcoholic liver disease model + tru-cut biopsy). After a histopathological evaluation by light microscopy, the sensitivity, specificity, positive and negative predictive values of FNAC and tru-cut biopsy for the diagnosis of liver lesions were calculated. RESULTS: No pathology was detected in GI except for mild congestion. On the other hand, hepatocyte damage, periportal inflammation, congestion, and fatty changes were detected in all liver tissues of the alcoholic liver disease groups. The sensitivity of hepatocyte damage, inflammation, congestion, and fatty change parameters for FNAC were 33.3%, 80%, 0%, and 0%, respectively, while the sensitivity of the same variables for tru-cut were 66.7%, 40%, 100%, and 20%, respectively. DISCUSSION: Both techniques were superior in some aspects. FNAC can be an attractive alternative to tru-cut biopsy and applied in routine practice in the diagnosis of non-tumoral liver diseases.
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    Effects of bedside adequacy assessment in thyroid cytology on cytological sufficiency and the final histopathological diagnosis
    (Cukurova Univ, Fac Medicine, 2020) Toyran, Tugba; Guvendi, Gulname Findik; Adali, Yasemen; Ustun, Huseyin
    Purpose: The thyroid fine needle aspiration cytology (FNAC) is a fast, reliable, and economical method for interpretation of thyroid nodules. This method contributes to the later management of patients and reduces unnecessary surgical interventions. This study aimed to demonstrate the contribution of bedside adequacy assessment during FNAC to the accuracy rates of cytological competence and final histological diagnosis. Materials and Methods: The study included 443 patients who underwent FNAC in a university hospital between 2012 and 2015. Correlations between the histological diagnosis categories of patients who had and who did not have bedside adequacy assessment were compared per sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy. Results: As a result of comparison of cytological and histopathological diagnoses, 30.7% sensitivity, 75% specificity, 50% positive predictive value, 57.1% negative predictive value and 55.1% diagnostic accuracy were found in the group with bedside adequacy assesment. Whereas the group without bedside adequacy assessment, 50% sensitivity, 69.2% specificity, 42.8% positive predictive value, 75% negative predictive value, and 63.1% 1% diagnostic were found Conclusion: Bedside adequacy assessment increases the cytological adequacy proportion, but does not contribute to the diagnostic accuracy rate.
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    Effects of Ozone and L-Carnitine on Kidney MDA, GSH, and GSHPx Levels in Acetaminophen Toxicity
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2020) Eroglu, Huseyin Avni; Makav, Mustafa; Adali, Yasemen; Citil, Mehmet
    This study aimed to determine the therapeutic effects of medical ozone and L-carnitine therapy on acetaminophen (APAP)-induced kidney damage by evaluating malondialdehyde (MDA), glutathione (GSH), and GSHPx levels. In this study, 56 rats were randomized into 8 groups with 7 rats in each group. Kidney injury was induced by the administration of a single dose N-acetyl-p-aminophenol (1 g/kg) orally.Therapeutic ozone (0.7 mg/kg) and L-carnitine (500 mg/kg) were administered intraperitoneally. After the therapy, the rat kidneys were homogenized, and the tissue MDA, GSH, and GSHPx levels were measured. Compared to the control groups, there were higher MDA levels in the kidney tissues only in the APAP, APAP + Ozone, and APAP + Ozone + L-carnitine groups (P<0.001). Besides, the decrease in the GSH and GSHPx levels of the kidney tissues in the study groups were significant compared to the control groups, and the highest decreases were observed in the APAP APAP + Ozone and APAP + Ozone + L-carnitine groups (P<0.001). Findings obtained from this study revealed that acetaminophen toxicity caused oxidative damage in the examined kidney tissues, and L-carnitine and/ or ozone applications for protective purposes decreased MDA levels, a product of lipid peroxidation, and increased tissue GSH levels thru GSHPx antioxidant enzyme activity. In this context, the most important protective effect was observed in the group where L-carnitine and ozone were administrated together.
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    Efficacy of Ozone and Selenium Therapy for Alcoholic Liver Injury: An Experimental Model
    (Int Inst Anticancer Research, 2019) Adali, Yasemen; Eroglu, Huseyin Avni; Makav, Mustafa; Guvendi, Gulname Findik
    Background/Aim: Alcoholic liver disease is an important health problem which is reversible during early stages of liver damage, but becomes permanent with time. Nowadays, many studies focus on various agents that prevent, reduce or slow the progression of the toxic effects of alcohol. In our study, we investigated the efficiency of ozone and selenium against oxidative damage in a model of alcohol-induced liver damage. Materials and Methods: Forty-eight female Wistar Albino rats between 4 and 6 months of age and weighing 190-250 g were included in the study and were used as models of alcohol liver damage. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum and tissue total oxidant levels, serum and tissue total antioxidant levels, and the histopathological evaluation of the liver were performed in 8 groups. Results: In the statistical analysis, it was observed that ozone and/or selenium therapies decreased the AST levels. Total oxidant and antioxidant serum levels were found to vary in serum and tissue. Ozone and/or selenium therapies decreased liver damage, according to histopathological findings. Conclusion: Through ozone and/or selenium therapies, less damage was observed histopathologically compared to the alcohol group. It is thought that the results of our study can be used in individual treatments following confirmation of liver damage in alcoholic patients.
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    Hepatoprotective and nephroprotective effects of Trigonella foenum-graecum L. (Fenugreek) seed extract against sodium nitrite toxicity in rats
    (Biomedpress, 2019) Atila Uslu, Gozde; Uslu, Hamit; Adali, Yasemen
    Introduction: Feeding habits and environmental factors may rival genetic susceptibility as etiological factors related to various cancers. Humans are continuously exposed to many synthetic food additives, one of which is sodium nitrite (NaNO2). There is a direct correlation between increases in consumption of nitrite-treated products and incidence of tissue damage, hepatotoxicity, nephrotoxicity and some types of cancer. The objective of this study was to investigate the protective effects of Trigonella foenurn-graecum (TFG) on NaNO2-induced hepatotoxicity and nephrotoxicity. Methods: Forty rats were randomly assigned (10 per group) to control (physiological saline solution), TFG (150 mg/kg/day), NaNO2 (80 mg/kg/day), and NaNO2+TFG (80 mg/kg/day + 150 mg/kg/day) groups. This group was offered TFG seed extract two hours before NaNO2. At the end of three months, the rats were decapitated, and blood, kidney and liver tissues were removed. Results: Three months of oral administration of NaNO2 increased serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, and pro-inflammatory cytokine levels in the liver and kidney tissues [except for liver Interleukin 1 alpha (IL-1 alpha)] of rats. Serum AST, ALT, urea, creatinine, liver IL-6, and kidney tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-1 alpha levels significantly decreased in the NaNO2 +TFG group compared to the NaNO2 group. Pathological examinations, it was determined show that exogenously administered TFG could alleviate the effects of NaNO2 hepatotoxicity and nephrotoxicity. Conclusions: Our results suggest that exogenous TFG mitigates NaNO2-administration induced hepatotoxicity and nephrotoxicity. TFG extract exerted antioxidative and anti-inflammatory effects, and played a significant role in preventing hepatic and renal damage induced by chronic NaNO2 administration.
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    Investigation of the Effects of Dimethyl Sulfoxide in Experimental Gout with Comparison of Dexamethasone and Indomethacin
    (Springer, 2024) Aydeger, Cemre; Adali, Yasemen; Makav, Mustafa; Eroglu, Hueseyin Avni
    Gout arthritis is an inflammatory arthritis characterized by increased serum uric acid and accumulation of monosodium urate (MSU) crystals in soft tissues. The treatment for gout arthritis is centered on reducing uric acid agents with long-term and anti-inflammatory agents during attack times. In recent studies, it is noteworthy that Indomethacin and Dexamethasone have positive effects in the treatment of gout. Dimethyl sulfoxide (DMSO) is a lipophilic solvent and has an anti-inflammatory effect at appropriate doses. Based on this information, for this study, the effects of these three agents were investigated in rats using a gut model to compare their efficacy. In the study, a total of 48 female 3-4-month rats were divided equally into 8 groups: Control, Indomethacin, DMSO, Dexamethasone, Gout, Gout+Indomethacin, Gout+DMSO, Gout +Dexamethasone. During the eight-week study, a gout arthritis model was used that included 10 mg MSU given intra-articularly in the right foot. Indomethacin 12.5 mg/kg intragastric, DMSO 0.1 ml intraperitoneally and dexamethasone 0.2 mg/kg were administered subcutaneously to the related groups once a day for seven days. At the end of the study, collected articular tissues were stained with haematoxylin and eosin after the fixation and decalcification processes were done. The findings obtained showed that inflammation was reduced in treatment groups compared to the Control groups (all p values 0.002). Also, synovial proliferation was remarkably decreased in the Gout+Dexamethasone group compared to the Gout group (p = 0.019). As a result of these findings, although the three agents all reduced inflammation in gout arthritis, DMSO was shown to be more advantageous due to its having fewer side-effects.
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    Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats
    (Mashhad Univ Med Sciences, 2018) Yayla, Muhammed; Cetin, Damla; Adali, Yasemen; Kilicle, Pinar Aksu; Toktay, Erdem
    Objective(s): The aim of this study is to determine the therapeutic effects of pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in rats. Materials and Methods: Fifty-six female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Operation, Group 2; Ischemia, Group 3; Ischemia + Reperfusion, Group 4; Ischemia + Pomegranate 0,32 ml / kg (IP), Group 5; Ischemia + Pomegranate 0.64 ml / kg, Group 6; Ischemia + Pomegranate 0,32 ml / kg + reperfusion, Group 7; Ischemia + Pomegranate 0,64 ml / kg + reperfusion. Three hours after ischemia and 3 hours after reperfusion, the study was terminated. Results: While NADPH oxidase activity, MDA and TNF-alpha levels were significantly increased, SOD activity and GSH levels were reduced in ischemia and I/R groups. Low dose pomegranate seed oil application reduced significantly oxidative stress and NADPH oxidase activity in both ischemic and ischemic/reperfusion groups. At the same time, low-dose pomegranate seed oil extract reduced TNF-alpha levels and significantly increased antioxidant activity. Conclusion: PSO demonstrated an important therapeutic effect in the treatment of ovarian ischemia and reperfusion injury.
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    Protective Effect of Ozone Against Gentamicin-Induced Neprotoxicity and Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels: An Experimental Study
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2019) Ustebay, Sefer; Ustebay, Dondu Ulker; Ozturk, Omur; Ertekin, Omer; Adali, Yasemen
    Our aim was to investigate the protective role of ozone treatment against gentamicin-induced nephrotoxicity in an experimental rat model. In this study, a total of 30 rats were allocated in 5 groups (n=6 in each group). The control group (Group 1) received isotonic saline only, while Groups 2 and 3 received gentamicin at doses of 15 mg/kg/day and 50 mg/kg/day, respectively. In Group 4, intraperitoneal ozone treatment (1 mg/kg, 5% O-3-95% O-2) was performed after administration of gentamicin at a dose of 15 mg/kg/day. Group 5 underwent ozone treatment intraperitoneally following the application of gentamicin (50 mg/kg/day). Nephrotoxicity was formed by administration of glycerol.Serum levels of urea, creatinine, neutrophil-gelatinase-associated lipocalin (NGAL), lactate dehydrogenase (LDH), total antioxidant capacity (TAC) and protein carbonyl were measured, and kidneys were histopathologically examined after the sacrifice of animals on the 5th, day. Group 4 displayed more favorable outcomes regarding biochemical markers of oxidative stress such as NGAL, LDH, creatinine, urea, TAC and protein carbonyl. Similarly, histopathological alterations indicating gentamicin-induced nephrotoxicity such as hemorrhage, the presence of protein casts and epithelial injury in renal tubules were less evident in Groups 4 and 5 which received ozone treatment. To conclude, results of this experimental study demonstrated that ozone treatment might ameliorate biochemical disturbances and histopathological alterations linked with gentamicin-induced nephrotoxicity. However, furthertrials are warranted to document the actual therapeutic potential of ozone treatment in the clinical setting.
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    Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model
    (Acta Cirurgica Brasileira, 2020) Kapicibasi, Hasan Oguz; Kiraz, Hasan Ali; Demir, Emin Tunc; Adali, Yasemen; Elmas, Sait
    Purpose: This experimental sepsis model created with Escherichia coil aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. Methods: Rats were divided into 5 groups. Then sepsis was induced intraperitoneally in the first 4 groups. The 1st group was treated with cefepime, the 2nd and 3rd groups were treated with cefepime combined with ozone at a dose of 0.6 mg/kg and 1.1 mg/kg. Lung tissue sections were stained with hematoxylin-eosin and assessed under light microscope and scored between 0-4 in terms of histopathological findings. Results: In the comparisons between Group 1 and Group 4 in terms of cellular damage (p=0.030), inflammation (p=0.000) and overall score (p=0.007), statistically significant positive effects were observed in favor of Group 1. In the comparisons of Groups 2 and 3 with Group 4, only positive effects were observed in terms of inflammation (p=0.020, p=0.012, respectively). Conclusion: Although negative histopathological effects of ozone on tissue injury were detected, it was noteworthy that the increase in the ozone dose reduced the number of damaged parameters.
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    The Investigation of the Effect of Ozone Therapy on Gout in Experimental Rat Models
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2019) Bilge, Ali; Tuysuz, Murat; Ozturk, Omur; Adali, Yasemen; Eroglu, Huseyin Avni; Makav, Mustafa; Atilla Uslu, Gozde
    The effect of ozone treatment in experimental rat gout arthritis was investigated. Twenty adult albino male rats were divided into 4 groups: Group 1 (Control) was followed without any medication, Group 2 (Gout control) was injected with a single dose of 0.2 mL (10 mg) monosodium urate (MSU) intraarticulary to 1st metatarsophalangeal joint to create experimental Gouty arthritis. Group 3 (Gout + Ozone) was injected intraarticulary to 1st metatarsophalangeal joint with a single dose of 0.2 mL (10 mg) MSU to generate experimental gout, followed by ozone therapy to the rats a single dose of 1 mL (10 mu g/mL) intraperitoneally daily for 3 weeks. The Group 4 (Ozone control) ozone therapy was given a single dose of 1 mL (10 mu g/mL) intraperitoneally daily for 3 weeks without gout formation. The results were recorded and compared statistically between the groups. In conclusion, the low level of inflammation in the third group (Gout + Ozone) was considered statistically significant as compared to the second group. With Ozone treatment the gout joint has been shown to have reduced acute inflammation, it has not been affected by the chronic proliferation process.
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    The Relationship Between Histopathologic Findings and Body Mass Index in Sleeve Gastrectomy Materials
    (Springer, 2019) Adali, Yasemen; Binnetoglu, Kenan; Eroglu, Huseyin Avni; Kaya, Nilhan; Guvendi, Gulname Findik
    ObjectiveFor treatment of obesity, which is one of the important health problems of the present time, lifestyle modification, pharmacotherapy, behavioral treatment methods, and surgical procedures are commonly used. Sleeve gastrectomy is widely used among surgical procedures. We aimed to investigate the relationship between histopathologic findings and body mass indices (BMIs) of cases with sleeve gastrectomy in our study.MethodsThirty-seven patients were included in our study who underwent sleeve gastrectomy and whose operation materials were examined histopathologically in our hospital. Two pathologists re-evaluated all gastrectomy materials. The relationship between BMI and the presence of gastritis, atrophy, intestinal metaplasia (IM), Helicobacter pylori (HPL), and other histopathological findings was investigated.ResultsThe mean age of patients included in the study was 34.7+9.3years. Of patients, 70.3% were female and 29.7% were male. There was a statistically significant difference between BMI and IM among the evaluated histopathologic parameters. Moreover, IM was significantly more present in patients with type 2 diabetes.ConclusionsThere is no previous study investigating the relationship between gastric histopathological findings and BMI in sleeve gastrectomy patients. We think that the statistically significant difference between BMI and IM that we found in our study may shed light on studies to be performed in the future.