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  • Küçük Resim
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    Serum brain-derived neurotrophic factor in the diagnosis of febrile seizure
    (John Wiley and Sons Inc, 2021) Çokyaman, Turgay; Kasap, Tolga; Şehitoğlu, Hilal
    Background Brain-derived neurotrophic factor (BDNF) is a noncovalently linked homodimer protein from the neurotrophic growth factor family. Although it is expressed throughout the brain, it is produced more intensively in the entorhinal cortex and hippocampus and can cross the blood-brain barrier in two directions easily. The aim of this study is to understand, for the first time, whether there is a relationship between febrile seizure (FS) and BDNF. Methods The study included cases diagnosed with FS and febrile illness, of similar age, weight, and height, between 6 months and 6 years. Samples for serum BDNF measurement were taken within the first 24-48 h of admission at the hospital and levels were measured using the commercial enzyme-linked immunosorbent assay kit and expressed in ng/mL. Results Eighty cases (40 FS, 40 febrile illness) were included in the study. The mean serum BDNF was found to be 6.7 +/- 2.4 ng/mL in the FS group and 4.5 +/- 2.6 ng/mL in the febrile illness group (P = 0.001). No relation was found between gender, age, body weight, length, and platelet counts and serum BDNF levels. The optimal cut-off value for serum BDNF was found to be 5.2 ng/mL (75% sensitivity, 62.5% specificity, AUC: 0.723) to distinguish between FS and febrile illness. Conclusions Excluding demographic variables such as gender, age, weight, length, and platelet counts serum BDNF levels have increased in children with FS. Considering the hippocampal origin of FS, we can suggest that the pathophysiology of FS may be related to the BDNF.
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    Öğe
    The diagnostic value of calcium binding protein S100A8/A9 and S100A12 in acute pancreatitis
    (MediHealth Academy Yayıncılık, 2022) Bardakcı, Okan; Daş, Murat; Şehitoğlu, Hilal; Çetin, Ece Ünal; Atalay, Ünzile; Küçük, Uğur; Kamış, Fatih
    Background: S100A8/A9 and S100A12 which are the major calcium-binding proinflammatory proteins secreted by granulocytes, has been proposed to be related to distinct disease states of inflammatory origin. This study aims to explore the circulating levels of S100A8/A9 and S100A12 in acute pancreatitis (AP) and reveal their relationship with conventional inflammatory markers. Material and Method: Serum S100A8/A9 and S100A12 were determined in AP patients (male/female: 17/13) by using a specific enzyme-linked immunosorbent assay (ELISA) method at both onset and remission and in 30 healthy controls (male/female: 17/13). Results: Significantly higher S100A8/A9 and S100A12 levels were found in AP patients compared to healthy controls (p
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    Öğe
    The relationship between the amount of edema and functional capacity and annexin V and ICAM 1 in patients with heart failure
    (Çanakkale Onsekiz Mart Üniversitesi, 2022) Duygu, Ali; Şehitoğlu, Hilal; Kaya, Hakkı; Arslan, Mehmet; Akşit, Ercan
    Objective: Edema, one of the common findings of congestive heart failure, can be seen in the form of pretibial, scrotal or pulmonary edema and always undesired changes the quality of life of patients. Some studies have previously demonstrated the correlation of some cytokines and inflammation markers with heart failure. This study purposed to investigate the relevance of the amount of edema and functional capacity with ICAM 1 and annexin V in heart failure patients. Methods: The study included a total of 40 individuals, 20 of whom were diagnosed with heart failure and 20 of whom were enrolled as the control group. Edema grades and functional capacities were scored and noted. All patients underwent transthoracic echocardiography. ICAM 1 and annexin V levels were compared between the patient and control groups. The correlation between the grade of edema and functional capacity and ICAM 1 and annexin V levels was examined. ROC curve analysis was used to determine the cut-off point. Results: There was a significant difference in both ICAM 1 and annexin V levels in the patient group compared to the control group (ICAM 1 58.14±25.65 ng/mL, 36.04±14.14 ng/mL, p [TR] Amaç: Konjestif kalp yetmezliğinin yaygın bulgularından biri olan ödem pretibial, skrotal ya da pulmoner ödem şeklinde görülebilmekte ve hastaların yaşam standartlarını daima olumsuz yönde etkilemektedir. Bazı sitokin ve inflamasyon markerlarının kalp yetmezliği ile korelasyonu daha önce kimi çalışmalarda gösterilmiştir. Amacımız; kalp yetmezliği hastalarında fonksiyonel kapasite ve ödem miktarı ile ICAM 1 ve annexin V arasında ilişkiyi incelemektir. Yöntem: Çalışmaya kalp yetmezliği tanısı almış 20 ve kontrol grubu olarak belirlenmiş 20 olmak üzere toplam 40 kişi alındı. Ödem dereceleri ve fonksiyonel kapasiteleri skorlanarak not edildi. Tüm hastalara transtorasik ekokardiografi yapıldı. Hasta ve kontrol grubu arasında ICAM 1 ve annexin V düzeyleri karşılaştırıldı. Ödem derecesi ve fonksiyonel kapasite ile ICAM 1 ve annexin V düzeyleri arasındaki korelasyona bakıldı. Kesim noktasının belirlenmesi için ROC Curve analizi kullanıldı. Bulgular: Hem ICAM 1 hem de annexin V düzeylerinde hasta grupta kontrol grubuna kıyasla anlamlı fark oluştu (ICAM 1 58.14±25.65 ng/mL, 36.04±14.14 ng/mL, p