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  • Küçük Resim
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    A case of acute brucellosis associated with HIV infection in Turkey
    (Termedia Publishing House Ltd, 2024) Ürkmez, Fatma Yekta; Alkan, Sevil
    Human brucellosis is a common public health problem in Turkey. Human immunodeficiency virus (HIV)-positive patients are vulnerable to co-infections and super-infections due to targeting the immune system. Because opportunistic infections are considered primarily, it is very difficult to detect co-infections, especially Brucella spp., in this patient group. In addition, non-specific clinical findings of brucellosis make diagnosis difficult. In this report, an HIV-positive patient with acute brucellosis was described. A 28-year-old male patient receiving antiretroviral therapy was admitted to the hospital with complaints of high fever and myalgia for the last two weeks. Physical examination revealed enlargement of bilateral cervical lymph nodes and enlargement of bilateral inguinal lymph nodes. Primarily, opportunistic infections were investigated in this patient. Brucella spp. was detected in blood cultures taken due to high fever. Subsequently, the patient was diagnosed with brucellosis. We presented this case report with the purpose of drawing more attention to the clinical diagnosis of brucellosis. In addition, we recommend that clinicians should be more cautious about fever of unknown origin in HIV-positive patients, especially in regions where brucellosis is endemic. In the presence of newly developing fever and lymphadenopathy in HIV-infected individuals, opportunistic infections as well as other infectious diseases, including brucellosis, should be considered.
  • Küçük Resim
    Öğe
    Predictive Significance of Laboratory Tests in Bacteremic Brucellosis
    (Iranian Scientific Society Medical Entomology, 2024) Çelik, Mehmet; Çiçek, Yeliz; Atalay, Ebru; Altındağ, Deniz; Akgül, Fethiye; Ürkmez, Fatma Yekta; Gürbüz, Esra; Alkan, Sevil
    Background: Brucellosis is one of the most common zoonotic infections. Although culture is the gold standard diagnostic method, bacterial growth in blood cultures may not always occur due to various factors. We aimed to investigate demographic, clinical, and laboratory findings that may have predictive significance for bacteremia in brucellosis. Methods: Patients older than 18 years of age followed up with a diagnosis of brucellosis between 2012 and 2022 were included in this retrospective multicenter study. They were divided into two main subgroups according to their Brucella species reproductive status as bacteremic and non-bacteremic. Results: A total of 743 patients, 370 (49.80%) bacteremic and 373 (50.20%) non-bacteremic brucellosis patients, were enrolled. The mean age of the bacteremic group (36.74 years) was lower than the non-bacteremic group (43.18 yr). High fever, chills/cold, sweating, nausea, vomiting, and weight loss were more common in the bacteremic group. In the bacteremic group, white blood cell count, platelet count, hemoglobin level, mean platelet volume, eosinophil, and neutrophil counts were lower, and lymphocyte, erythrocyte sedimentation rate, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and ferritin levels were higher. According to the receiver operating characteristic (ROC) analysis, when the cut-off value of ferritin was considered 67, it was the parameter with the strongest predictive significance in Brucella bacteremia. Conclusion: High ferritin level, low eosinophil count, and increased erythrocyte sedimentation rate were determined as the most critical laboratory findings in predicting bacteremia in brucellosis.