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    Effects of direct therapeutic radiation on pulpal surface of root dentin: an in vitro study
    (Springer Science and Business Media Deutschland GmbH, 2023) Deniz, Yeşim; Işıktaş Acar, Ezgi; Çetin Genç, Çiğdem
    The aims of the study were to analyze the effects of therapeutic radiation on human root dentin samples from the aspect of possible alterations in crystallinity, micro-morphology, and composition. Fifty-six root dentin specimens were divided into seven groups (0, 10, 20, 30, 40, 50, and 60 Gy). Scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD) analyses were performed on pulpal surfaces of root dentin after being irradiated by 6MV photon energy. Mineral compositions, Ca/P, P/N, Ca/N ratios, and hydroxyapatite pikes were calculated. Some deuteriations on the dentin surface were observed in SEM images after 30 Gy and subsequent doses. One-way ANOVA revealed that there was no significant alteration in weight percentages of C, O, Mg, Ca, P, and N between groups. Radiation did not influence stoichiometric Ca/P, Ca/N, and P/N molar ratios. XRD analysis did not show a remarkable decline in hydroxyapatite pikes by the increasing doses. Radiotherapy changes the micromorphology of circumpulpal dentin but does not affect elemental composition and crystallinity.
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    Nano-hydroxyapatite incorporated quince seed mucilage bioscaffolds for osteogenic differentiation of human adipose-derived mesenchymal stem cells
    (Elsevier B.V., 2022) Çetin Genç, Çiğdem; Yılmaz, Hilal Deniz; Karaca, Burak; Kıran, Fadime; Arslan, Yavuz Emre
    In this study, the therapeutic hydrocolloid quince seed mucilage (QSM) from Cydonia oblonga Miller fruit is enriched with needle-like nano-hydroxyapatite (nHAp) crystals to fabricate a novel biomimetic osteogenic bioscaffold. The molecular weight (Mw) of water-based extracted QSM was measured with GPC (8.67 × 105 g/mol), and the composite blend was prepared at a ratio of 1:1 (w/w) QSMaq and nHAp. The porous bioscaffolds were manufactured by the freeze-drying method, and evaluated in-depth with advanced analyses. The XRD, ATR-FTIR, SEM-EDX, and elemental mapping analyses revealed a uniform coated semi-crystalline structure with no covalent bindings between QSM and nHAp. Moreover, due to the hydrocolloid backbone, a supreme swelling ratio (w/w, 6523 ± 190%) with suitable pore size (208.12 ± 99.22 μm) for osteogenic development was obtained. Further, the cytocompatible bioscaffolds were evaluated for osteogenic differentiation in vitro using human adipose-derived mesenchymal stem cells (hAMSCs). The immuno/histochemical (I/HC) staining revealed that the cells with the spherical morphology invaded the pores of the prepared bioscaffolds. Also, relatively early up-regulated osteogenic markers were observed by the qRT-PCR analyses. Overall, it is believed that the QSM-nHAp bioscaffolds might be favorable in non-load bearing applications, especially in the cranio-maxillofacial region, due to their regenerative, bendable, and durable features.
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    Students' Perceptions About the Instructors' Competence in Technology-supported Courses at Dental Faculty: A Cross-sectional Study
    (Aydın Adnan Menderes University, 2023) Çetin Genç, Çiğdem; Deniz, Yeşim; Genç, Celal; Değirmenci, Alpin; Tosun, İlgi
    Objective: The pandemic has highlighted the importance of technology-supported courses throughout the world. Evaluating the perceptions of students attending these courses is important to provide high-quality education. Materials and Methods: This study was carried out on 1st, 2nd, and 3rd-grade dentistry students. The Student Perceptions Scale Regarding the Knowledge of Instructors in Technology - Supported Classrooms was applied to 207 dentistry students. This scale consists of four sub-dimensions: subject matter knowledge (SMK), technological knowledge (TK), knowledge of students' understanding (KSU), and technological pedagogical content knowledge (TPCK). Results: SMK, KSU, and TPCK sub-dimension scores did not significantly differ by gender (p>0.05). However, the mean TK score of females (3.55 +/- 0.47) was found to be significantly higher than that of males (3.28 +/- 0.59) (p=0.001). There was no statistically significant difference among the SMK, TK, KSU, and TPCK sub-dimension mean scores by age (p>0.05). There was a statistically significant difference in the mean scores of the SMK and KSU sub-dimensions by grade (p-values are p<0.001 and p=0.015 respectively). The mean TK and TPCK sub-dimension scores yielded no significant difference by grade (p-values are p=0.368 and p=0.050 respectively). Conclusion: Measuring the quality of technology-assisted teaching and the instructor's TPCK from the student's perspective and determining student perceptions will provide accurate data on the long-term quality of education.
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    Unveiling Bone and Dental Regeneration Potential of Quince Seed Mucilage-Nanohydroxyapatite Scaffolds in Rabbit Mandibles
    (Wiley, 2025) Çetin Genç, Çiğdem; Yılmaz-Dağdeviren, Hilal Deniz; Deniz, Yeşim; Derkuş, Burak; Değirmenci, Alpin; Arslan, Yavuz Emre
    Donor-side morbidity of autografting for maxillofacial region defect regeneration has directed attention to bioengineered scaffolds. Composite scaffolds that mimic the bone extracellular matrix (ECM) are the potential candidates for defect reconstruction. Herein, a plant-based regenerative hydrogel, quince seed mucilage (QSM), was enriched with the nanohydroxyapatite (nHAp) particles to construct composite scaffolds (QSM/nHAp). The emerging scaffold is able to induce cellular spheroid formation and regenerate the critical-sized bilateral mandibular defects in rabbits. The macroscopic observations, histochemical (HC) and immunohistochemical (IHC) stainings, mu-computer tomography (CT) scanning, quantitative real time-polymerase chain reaction (qRT-PCR) analyses, and scanning electron microscopy (SEM) imaging revealed that all QSM/nHAp scaffolds were swelled with host blood, filled the whole cavity, and sustained cellular infiltration without adverse reactions. The gradual biodegradation profile of the scaffolds improved bone regeneration by releasing nHAp particles from the scaffold. Strikingly, co-development of dental and bone regeneration was observed for all QSM/nHAp groups beginning after day 21. Moreover, QSM/nHAp scaffolds induced expression (> 2-fold) of bone and dental-related gene and protein expressions at the grafted area and sustained a proper platform for maxillofacial remodeling. Therefore, we strongly believe that such biocompatible plant-based constructs, compared with conventional medical devices used in maxillofacial surgery, could support and induce simultaneous bone and dental regeneration due to the intrinsic dynamics of the material.