Browsing by Author "Ay, Mehmet"
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Elucidation of the effects of fermented spirulina protein hydrolysate and bioactive peptide fractions on anti-inflammatory, anticancer, and indirect antioxidant mechanisms for therapeutic and nutraceutical applications
Cinar, Zeynep Özlem (Çanakkale Onsekiz Mart Üniversitesi, 2023)Artan metabolik sendrom oranı, inflamatuvar ve enfeksiyon hastalıkları nedeniyle takviye edici ürünlere ve sağlıklı beslenmeye olan ilgi giderek artmaktadır. Bu bağlamda, Spirulina platensis, sağlığa yararlı özellikleri ... -
Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) - A Review
Cömert Önder, Ferah; Kalın, Sevil; Şahin, Nebahat; Davutlar, Gülce; Abusharkh, Khaled A.N.; Maraba, Özlem; Ay, Mehmet; Hal, Rabia Selina (Tabriz University of Medical Sciences, 2024)In recent years, the incidence of cancers, inflammatory diseases, Alzheimer's disease, glucose metabolism disorder and diabetes has increased alarmingly which demands more research into the discovery of new drug candidates ... -
Nitro Compounds Inhibit Breast Cancer Cell Proliferation, Migration, and Colony Formation: Molecular Docking, Molecular Dynamics Simulations and Pharmacological Properties
Cömert Önder, Ferah; Şahin, Nebahat; Davutlar, Gülce; Önder, Alper; Ay, Mehmet (John Wiley and Sons Inc, 2023)In this study, the concept of combined in vitro and in silico studies were utilized by using some synthesized nitro bearing compounds. The anticancer activities of the studied compounds were performed by using colony ... -
Nitroredüktaz esaslı kanser tedavisine yönelik aromatik ve heterosiklik ilaç-öncü bileşiklerin geliştirilmesi
Güngör, Tuğba (Çanakkale Onsekiz Mart Üniversitesi, Lisansüstü Eğitim Enstitüsü, 2016)Bu tez çalışmasında; kanser tedavisinde, gen yönlendirilmiş enzim ilaç öncü bileşik yaklaşımında kullanılacak, CB 1954 bileşiğinden daha etkili olması beklenen, nitro işlevsel grubu içeren aromatik ve/veya heterohalkalı ... -
Prodrugs for Nitroreductase Based Cancer Therapy-5: Development of Trinitroaniline Prodrugs/Ssap-NtrB Combinations for Liver Cancer Using Intracellular and Extracellular Conditions
Hacıoğlu, Nelin; Güngör, Tuğba; Tokay, Esra; Ay, Mehmet (John Wiley and Sons Inc, 2021)In this study, a series of trinitroaniline derivatives (TNA1-8) were synthesized and investigated as potential antitumor agents for enzyme-prodrug therapy. Enzymatic efficiency of Ssap-NtrB on prodrug candidates was ... -
Synthesis of isothiocyanate derivatives and biological activities of H2S releasing compounds
Yılmaz, Yakup Berkay (Çanakkale Onsekiz Mart Üniversitesi, Lisansüstü Eğitim Enstitüsü, 2022)Inflammation involves various pathways and signaling processes to eliminate detrimental stimuli including various pathogens and cell damage. Prolonged inflammation is referred to as chronic inflammation and is related to ... -
Target-Driven Design of a Coumarinyl Chalcone Scaffold Based Novel EF2 Kinase Inhibitor Suppresses Breast Cancer Growth In Vivo
Cömert Önder, Ferah; Kahraman, Nermin; Bellur Atıcı, Esen; Çağır, Ali; Kandemir, Hakan; Tatar, Gizem; Ay, Mehmet (Amer Chemical Soc, 2021)Eukaryotic elongation factor 2 kinase (eEF-2K) is an unusual alpha kinase involved in protein synthesis through phosphorylation of elongation factor 2 (EF2). eEF-2K is highly overexpressed in breast cancer, and its activity ...
