Browsing by Author "Çayır, Akın"
Now showing items 1-7 of 7
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Assessment of the genotoxic potential of tetrachlorvinphos insecticide by cytokinesis-block micronucleus and sister chromatid exchange assays
Çobanoğlu, Hayal; Çayır, Akın (SAGE Publications, 2021)Tetrachlorvinphos is an organophosphate that is classified as a carcinogen in humans by several authorities. Due to very limited data regarding the genotoxic potential, we aimed to comprehensively investigate in vitro ... -
The emergent role of mitochondrial RNA modifications in metabolic alterations
Boughanem, Hatim; Bottcher, Yvonne; Tome-Carneiro, Joao; Lopez de Las Hazas, Maria-Carmen; Davalos, Alberto; Çayır, Akın; Macias-Gonzalez, Manuel (John Wiley and Sons Inc, 2023)Mitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA types of mitochondria. Although the number of mitochondrial RNA modifications is less than those in cytoplasm, substantial ... -
Exposure to glyphosate and tetrachlorvinphos induces cytotoxicity and global DNA methylation in human cells
Ergün, Hacer; Çayır, Akın (SAGE Publications, 2021)Two organophosphate pesticides—glyphosate and tetrachlorvinphos—have been announced as carcinogens to humans by various authorities, including the European Chemical Agency and the Environmental Protection Agency. We aimed ... -
m6A Regulators in Human Adipose Tissue-Depot-Specificity and Correlation With Obesity
Ronningen, Torunn; Dahl, Mai Britt; Valderhaug, Tone Gretland; Çayır, Akın; Keller, Maria; Toenjes, Anke; Blueher, Matthias; Boettcher, Yvonne (Frontiers Media S.A., 2021)Background: N6-methyladenosine (m6A) is one of the most abundant post-transcriptional modifications on mRNA influencing mRNA metabolism. There is emerging evidence for its implication in metabolic disease. No comprehensive ... -
Occupational exposure to radiation among health workers: Genome integrity and predictors of exposure
Çobanoğlu, Hayal; Çayır, Akın (Elsevier B.V., 2024)The current study aimed to investigate genomic instabilities in healthcare workers who may experience varying levels of radiation exposure through various radiological procedures. It also sought to determine if factors ... -
RNA A-to-I editing, environmental exposure, and human diseases
Çayır, Akın (Taylor and Francis Ltd., 2021)Epigenetic modifications have gained attention since they can be potentially changed with environmental stimuli and can be associated with adverse health outcomes. Epitranscriptome field has begun to attract attention with ... -
RNA modifications as emerging therapeutic targets
Çayır, Akın (John Wiley and Sons Inc, 2021)The field of epitranscriptome, posttranscriptional modifications to RNAs, isstill growing up and has presented substantial evidences for the role of RNAmodifications in diseases. In terms of new drug development, RNA ...
