Rod-like L-Aspartic acid-Cu(II) metal organic frameworks; Synthesis, characterization and biomedical properties

Abstract

L-aspartic acid (L-AA) based MOFs were prepared from acetate, chloride, nitrate, and sulfate salts of Cu(II) ions as L-AA-Cu(II)-A,-C,-N,-S, respectively with 96.7 2.4, 89.8 3.1, 92.1 1.5, 74.6 5.2 m2/g, surface areas. L-AA- Cu(II)-MOFs in the same order induced 0.43 0.25%, 0.94 0.24%, 0.91 0.40%, 1.18 0.10% hemolysis, all being <2%, and blood clotting indices of ~90% and can be considered nonhemolytic and non-coagulative at 1 μg/mL concentration. L-AA-Cu(II)-A MOFs exhibited 86.3 0.2, and 92.4 0.6% α-Glucosidase inhibitory ac- tivities at 1.0 and 10.0 μg/mL concentrations, respectively. Moreover, L-AA-Cu(II)-S MOFs had effective anti- microbial activities against E. coli (ATCC-8739), and S. aureus (ATCC-6538) with MIC values of 0.63 mg/mL and 1.25 mg/mL for C. albicans (ATCC-10231). L-AA-Cu(II) MOFs synthesized herein with hemocompatible, antimi- crobial and antidiabetic properties prompt interesting possibilities for both industrial and biomedical applications