Browsing by Author "Hacıoğlu, Nelin"

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Prodrugs for Nitroreductase Based Cancer Therapy-5: Development of Trinitroaniline Prodrugs/Ssap-NtrB Combinations for Liver Cancer Using Intracellular and Extracellular Conditions

Hacıoğlu, Nelin; Güngör, Tuğba; Tokay, Esra; Ay, Mehmet (John Wiley and Sons Inc, 2021)

In this study, a series of trinitroaniline derivatives (TNA1-8) were synthesized and investigated as potential antitumor agents for enzyme-prodrug therapy. Enzymatic efficiency of Ssap-NtrB on prodrug candidates was ...