Gulten, SirinArslan, Ezgi2025-01-272025-01-2720180022-152X1943-5193https://doi.org/10.1002/jhet.3367https://hdl.handle.net/20.500.12428/21757Biologically important 21 new symmetrical bis 3,4-dihydropyrimidin-2(1H)-ones/thiones were synthesized by reacting 4,4 '-diaminodiphenyl ether/4,4 '-ethylenedianiline with tert-butyl acetoacetate to produce diphenyl ether-bridged bis beta-keto amide/diphenyl ethane-bridged bis beta-keto amide then treated with urea or thiourea and an appropriate aldehyde with either a catalytic amount of p-TSA center dot H2O or conc. HCl in ethanol afforded the title compounds.eninfo:eu-repo/semantics/closedAccessChlorideDihydropyrimidinonesDerivativesBlockersBromideDiethylArticle55122936294510.1002/jhet.3367Q3WOS:0004534573000322-s2.0-85056197815Q2