Comez, Arza TaskiranCakir, Dilek UlkerTutunculer, Funda KirtayGencer, BaranTufan, Hasan Ali2025-01-272025-01-2720142222-39592227-4898https://doi.org/10.3980/j.issn.2222-3959.2014.03.06https://hdl.handle.net/20.500.12428/24798AIM: To evaluate the relationship between increased intraocular pressure (IOP), ischemia-modified albumin levels in serum (IMA-s) and in humor aqueous (IMA-(HA)) in rabbits. METHODS: Twenty-five albino New Zealand rabbits weighing between 2.0 and 2.8 kg were used in this pilot study. With permission from Canakkale Onsekiz Mart University Animal Ethics Committee, the 10P of both eyes of each rabbit were recorded with a Tonopen (Tono-Pen XL, Reichart Inc., Depew, NY, USA) after the application of topical proparacaine 0.5% HCI anesthesia. Blood (4 mL) was collected from the marginal ear vein and an intracameral injection of 2.3 mg/mL sodium hyaluronate and subconjunctival dexamethasone was given in the right eye. Anterior chamber aqueous fluid was obtained using a timbal approach with a 27 gauge needle from both eyes. The left eyes were used as controls. 10P was measured on the 1st, 3rd and 10th day after the initial injection, with Tonopen, IMA -s levels and IMA -(HA) examined simultaneously. RESULTS: Before the injections, 10P was 11.4 +/- 3.0 mm Hg in the right eye and 11.3 +/- 3.1 mm Hg in the left eye (P> 0.05). There was a statistically significant difference between IMA-s levels before the IOP increase (IMA-s(o)) and IMA-s levels on the 1st and 3rd days after the increase in 10P (P=0.012 and P=0.01, respectively). No difference was observed between IMA -s(o) and serum IMA levels on the 10th day (IMA-s10) after IOP increase (P=0.989). IMA-HA in the right eye in the first day after the injection was positively correlated with 10P(gamma =0.748; P=0.02).No other correlation is found between any other parameter With IMA-Fik levels at any test time. A statistically significant positive correlation was observed between IMA-s values and 10P on the 1st and 3rd days(r =0.398, P =0.04 and r = 0.382, P =0.04, respectively). There was no correlation between IMA-s levels and increased 10P on the 10th day after kW increase (r =0.026, P =0.902). CONCLUSION: IMA may be an important indicator of acute damage caused by diseases involving ischemic damage to the eye, especially in case of increased intraocular pressure.eninfo:eu-repo/semantics/closedAccessischemia-modified albuminintraocular pressureserumhumoi aqueousrabbiteyeArticle7342142510.3980/j.issn.2222-3959.2014.03.06Q4WOS:0003376584000062-s2.0-8490382230724967184Q2