Kaymaz, BurakÇoban, GanimeGöksel, FerdiToman, HüseyinGölge, Umut HatayKömürcü, Erkam2025-01-272025-01-2720192458-88652459-1505https://search.trdizin.gov.tr/tr/yayin/detay/372046https://hdl.handle.net/20.500.12428/20138Introduction: Ischemia is reversible or irreversible cell/tissue damage that is secondary to insufficient blood flow to tissues or organs. Ischemia causesmany metabolic and structural changes at the cellular level. Ozone therapy is often used as an antioxidant remedy. This study aimed to investigate theeffects of ozone therapy on extremity ischemia-reperfusion (IR) injury.Methods: Twenty-four New Zealand White (NZW) rabbits were randomly allocated into three groups. Each group consisted of eight rabbits. Group Iwas the control group, Group II was the ischemia group, and Group III, the ozone group. Femoral arteries of the right legs were dissected, and femoralarterial occlusion was performed in Group II and III. Hematological and histopathological evaluation was performed in all groups.Results: The levels of total antioxidant status (TAS) after the surgical procedure was higher in the ozone group compared to the ischemia group(p=0.036). In addition, the levels of malondialdehyde (MDA) after the surgical procedure were lower in the ozone group compared to the ischemiagroup but not statistically significant (p=0.093). The control and ozone groups were histopathologically similar.Conclusions: Ozone therapy may be used as an alternative treatment modality with its anti-inflammatory and antioxidant effects for the treatment ofextremity IR injuryeninfo:eu-repo/semantics/openAccessTıbbi Araştırmalar DeneyselGenel ve Dahili TıpArticle437984372046