Edremitlioglu, MustafaAndic, Mehmet FatihKorkut, Oguzhan2025-01-272025-01-2720122146-31232146-3131https://doi.org/10.5152/balkanmedj.2011.002https://hdl.handle.net/20.500.12428/26612Objective: The role of oxidant damage on the development of end-organ injuries caused by diabetic rat is well known. The aim of this study is to examine the effect of quercetin, which is a strong antioxidant bioflavonoid, on oxidant damage and antioxidant capacity in various organs in the case of medium-term or long-term diabetic rat. Material and Methods: Forty-eight male Wistar rats were divided into five groups, namely, control group, diabetic group of 8-weeks, diabetic group of 16-weeks, quercetin treated diabetic group of 8-weeks, and quercetin treated diabetic group of 16-weeks. At the end of the experiment, malondialdehyde levels, superoxide dismutase, catalase, and glutathione peroxidase activities, were measured in the lung, aorta, heart, spleen, liver, and kidney tissues. Results: MDA levels were elevated in all tissues except in the lung in non-treated diabetic groups. Quercetin treatment increased the antioxidant enzyme capacities and considerably reduced oxidant damage. Conclusion: We suggest that quercetin has a protective effect on the aorta, heart, brain, liver, and kidneys from oxidant damage in the case of medium-term or long-term diabetic rat. It can be argued that quercetin is effective by increasing the antioxidant defence capacity in this process.eninfo:eu-repo/semantics/openAccessQuercetindiabetic ratoxidative damageantioxidant enzymesArticle291495510.5152/balkanmedj.2011.002Q4WOS:0003036184000102-s2.0-84862086444Q1