Taşkiran Çömez, ArzuKömür, BarişŞanal, ElifTufan, Hasan Ali2025-01-272025-01-2720131300-0292https://doi.org/10.5336/medsci.2012-30139https://hdl.handle.net/20.500.12428/13494Objective: To evaluate the relationship between tear osmolarity, Ocular Surface Disease Index (OSDI© Allergan Inc., Irvine, Calif), Schirmer test and tear break-up time (TBUT). Material and Methods: After performing Ocular Surface Disease Index (OSDI©) survey, tear osmolarity testing with TearLab osmolarity system, Schirmer test without anesthesia and TBUT measurement were performed in 40 patients with dry eye syndrome diagnosis and 39 healthy subjects. Student t-test and Spearman's rho correlation analysis are used for statistical evaluation. Results: The mean tear osmolarity was 307±19.2 mOsm/l in group A, while it was 292.9±13.9 mOsm/l in group B. Schirmer test results were in normal ranges in both groups (13.4±7.5 mm in group A, and 17.4±8.5 mm in group B). TBUT was lower in group A, and the difference between two groups was statistically significant. OSDI© scoring was 43.9±20.4 in group A, while it was 8.56± 5.2 in group B and the difference was statistically significant. The sensitivity and spesificity of tear osmolarity for threshold value 305 mOsm/l were found to be 76.9 % and 80%, for TBUT for 10 seconds were 94.7% and 71.8%; for OSDI© score >15 were 79.5% and 70% and for Schirmer's test for 10 mm were 35.9% and 80%. Conclusion: Of all tests, TBUT, tear osmolarity and OSDI© are found to be successful in discriminating dry eye patients from healthy participants. The specificity and the sensitivity of the commonly used Schirmer test are found to be low. © 2013 by Türkiye Klinikleri.eninfo:eu-repo/semantics/openAccessDiagnostic tests; Dry eye syndromes; Osmolar concentration; Routine; Sensitivity and specificity; TearsArticle33245546310.5336/medsci.2012-301392-s2.0-84874608628Q4