Erdem, AhmetMutlu, DogukanKilincarslan, RafetDayan, OsmanArslan, Sevki2025-01-272025-01-2720242069-5837https://doi.org/10.33263/BRIAC144.082https://hdl.handle.net/20.500.12428/13225In this article, cytotoxic and apoptotic properties of previously synthesized and characterized four different half?sandwich ruthenium (II) complexes (C1-C4) with 2-(2¢-quinoly) benzimidazole frameworks (L1-L5) were described. These Ru (II) complexes (C1-C4) had strong cytotoxic activity towards the human glioblastoma (U373) cancer cell line with low toxicity to the non-cancerous human embryonic kidney (HEK293) cell line. Mechanistic studies revealed that all complexes caused apoptosis induction by activating caspases with upregulation of Bax and downregulation of Bcl-2. Our results indicate that ruthenium (II) complexes with 2-(2¢-quinoly) benzimidazole frameworks, especially C1 and C4, had a higher cytotoxic and apoptotic activity in human glioblastoma cells, and they should be further evaluated in detail for its anticancer properties as a new therapeutical strategy for glioblastoma. © 2024 by the authors.eninfo:eu-repo/semantics/closedAccess2-(2¢-quinoly)benzimidazole; anticancer; glioblastoma; half-sandwich Ru(II); piano-stool complexArticle14410.33263/BRIAC144.0822-s2.0-85204957010Q2