Demirtürk, NeşeAygen, BilgehanÇelik, İlhamiMıstık, ReşitAkhan, SılaBarut, ŞenerŞener, Alper2023-06-122023-06-122021Demirtürk, N., Aygen, B., Çelik, İ., Mıstık, R., Akhan, S., Barut, Ş., . . . Doğan, N. (2021). Real-world data from Turkey: Is sofosbuvir/ledipasvir with or without ribavirin treatment for chronic hepatitis C really effective? Turkish Journal of Gastroenterology, 32(2), 155-163. doi:10.5152/tjg.2020.195692148-5607https://doi.org/10.5152/tjg.2020.19569https://hdl.handle.net/20.500.12428/4298Background: In this study, we aimed to investigate the efficacy and safety of sofosbuvir-based therapies in the treatment of chronic hepatitis C in real-world clinical practice. Methods: Data from patients with chronic hepatitis C treated with SOF/LDV ± RBV or SOF/RBV in 31 centers across Turkey between April 1, 2017, and August 31, 2018, were recorded in a nationwide database among infectious disease specialists. Demographics, clinical, and virological outcomes were analyzed. Results: A total of 552 patients were included in the study. The mean age of the patients was 51.28 ± 14.2, and 293 (55.8%) were female. The majority had HCV genotype 1b infection (65%), 75.04% of the patients underwent treatment, and non-cirrhosis was present at baseline in 381 patients (72.6%). SOF/LDV ± RBV treatment was given to 477 patients and 48 patients received SOF/RBV according to HCV genotype. The total SVR12 rate was 99% in all patients. Five patients experienced disease relapse during the study and all of them were genotype 2. In patients infected with HCV GT2, SVR12 was 77.3%. SVR was 100% in all patients infected with other HCV genotypes. All treatments were well tolerated by patients without causing severe adverse events. Side effects and side effects-associated treatment discontinuation rates were 28.2% and 0.4%, respectively. Weakness (13.7%) was the common side effect. Conclusion: The present real-world data of 525 patients with HCV genotypes 1, 1a, 1b, 3, 4, and 5 who underwent SOF/LDV ± RBV treatment in Turkey demonstrated a high efficacy and safety profile. HCV GT2 patients should be treated with more efficacious treatment.eninfo:eu-repo/semantics/openAccessChronic hepatitis CGenotypeLedipasvirReal-world dataSofosbuvirSustained virological responseArticle32215516310.5152/tjg.2020.19569Q4WOS:0006488164000072-s2.0-8510649795051187033960939