Topaloglu, NaciKucuk, AdemTekin, MustafaYildirim, SuleErbas, MesutKiraz, Hasan AliCakir, Dilek Ulker2025-01-272025-01-2720151022-386Xhttps://hdl.handle.net/20.500.12428/13622Objective: To establish whether the Ischemia-Modified Albumin (IMA), a new parameter of oxidative stress, has diagnostic role in experimental acute pancreatitis. Study Design: Randomized controlled trial. Place and Duration of Study: Experimental Animal Center, Çanakkale Onsekiz Mart University, çanakkale, Turkey, from May to September 2013. Methodology: Sixteen Sprague-Dawley rats were randomly divided into two groups (n=8 each): Sham and AP groups. AP was induced by ligation of pancreatic duct. Serum IMA, amylase, lipase, AST, ALT and CRP were determined. The severity of pancreatitis was scored by a blinded pathologist under microscope. Results: Serum IMA levels in the AP group increased significantly compared with the control group (p < 0.05). There was also a strong positive correlation between amylase and IMA levels. Conclusion: The present study showed in a rodent model that serum IMA might serve as an additional marker to monitor inflammation during pancreatitis.eninfo:eu-repo/semantics/closedAccessAcute pancreatitis; Amylase; Ischemia-modified albumin; RodentArticle2563953982-s2.0-8493081435126100988Q2