Şahin, Hacı ÖztürkGürlek, BerilDemir, BülentSılan, Fatma2025-01-272025-01-2720211300-47512602-4918https://doi.org/10.21613/GORM.2020.1070https://search.trdizin.gov.tr/tr/yayin/detay/510893https://hdl.handle.net/20.500.12428/15389OBJECTIVE: The persistence of high-risk human papillomavirus (HPV) infections, most of which are\rknown to be transient is of critical importance for the development of precursor lesions and cancer in the\rcervix. The aim of the present study is to investigate the persistence and clearance of genotype-based\rHPV infections and also some cofactors that could be effective in persistence.\rSTUDY DESIGN: Data of 115 patients whose human papillomavirus and genotype detection was made\rwith multiplex PCR (Polymerase chain reaction), and capillary electrophoresis were categorized as lowrisk HPV (LR-HPV)/high risk HPV (HR-HPV) and single/multiple HPV infections, and clearance/persistence data of two years were investigated.\rRESULTS: While 82 (71.3%) out of 115 patients (mean age 40.1 years) had a single HPV infection, the\rremaining had two or more HPV infections. Of all HPV infections, 81.5% (128/157) were HR-HPV.\rClearance rates of HPV infections during the first two years was 85.4% (134/157), persistence was 14.6%\r(23/157). The most frequently persisted HR-HPV genotypes were 31, 52, 68, 16, and 35, respectively. A\rstatistically significant difference was not found in HPV persistence with regard to the infection’s being\rsingle/multiple or LR/HR. A significant difference was not found between age groups and persistence.\rCONCLUSIONS: Of HPV infections, 85.4% are cleared during the first two years while the most frequently persisted HR-HPV genotypes were 31, 52, 68, 16, and 35, respectively. Being aware of population-based clearance/persistence results of type-specific infections may specify screening strategies.eninfo:eu-repo/semantics/openAccessKadın Hastalıkları ve DoğumGenel ve Dahili TıpMikrobiyolojiBiyoteknoloji ve Uygulamalı MikrobiyolojiArticle27326827210.21613/GORM.2020.1070510893