Şahiner, NurettinUmut, EvrimSağbaş Suner, SelinŞahiner, MehtapCulha, MustafaAyyala, Ramesh S.2025-02-062025-02-062022Şahiner, N., Umut, E., Sağbaş Suner, S., Şahiner, M., Culha, M., & Ayyala, R. S. (2022). Hyaluronic acid (HA)-Gd(III) and HA-Fe(III) microgels as MRI contrast enhancing agents. Carbohydrate Polymers, 277. https://doi.org/10.1016/j.carbpol.2021.1188730144-8617 / 1879-1344https://doi.org/10.1016/j.carbpol.2021.118873https://hdl.handle.net/20.500.12428/29554Hyaluronic acid (HA) was crosslinked with Gd(III) and Fe(III) ions rendering physically crosslinked HA-metal(III) microgels as magnetic resonance imaging (MRI) enhancing contrast agents. These HA-Gd(III) and HA-Fe(III) microgels are injectable with size range, 50–5000 nm in water. The same isoelectric point, pH 1.2 ± 0.1, was measured for both microgels. HA-Gd(III) and HA-Fe(III) microgels are hemo-compatible biomaterials and can be safely used in intravascular applications up to 1000 μg/mL concentration. Furthermore, no significant toxicity was attained as 95 ± 8 and 81 ± 2% cell viability on L929 fibroblast cells at 100 μg/mL of HA-Gd(III) and HA-Fe(III) microgels were measured. Moreover, HA-Gd(III) microgels were found to afford significant contrast improvement capability in MRI with proton relaxivity, r1 = 2.11 mM−1 s−1, comparable with the values reported for Gd(III) labeled functionalized HA gel systems and commercial Gd based contrast agents.enginfo:eu-repo/semantics/closedAccessBlood compatibleFe(II) chelatingHA-Fe(III) microgelHA-Gd(III) microgelHyaluronic acid (HA)Magnetic resonance imaging (MRI)article27711010.1016/j.carbpol.2021.118873Q1WOS:0007611284000092-s2.0-85119953736PMID: 34893278Q1