Ergin Tuncay, MerveAtagün, Murat İlhanErel, Özcan2024-01-162024-01-162023Ergin Tuncay, M., Atagün, M. I., & Erel, O. (2023). Thiol disulfide homeostasis in psychiatric disorders: A comprehensive review. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 123, 110719. https://doi.org/10.1016/j.pnpbp.2023.1107190278-58461878-4216https://doi.org/10.1016/j.pnpbp.2023.110719https://hdl.handle.net/20.500.12428/5242Thiol-disulfide couple maintains an intracellular redox status. Dynamic thiol-disulfide homeostasis acts crucial parts in metabolic processes involving signal mechanisms, inflammation, antioxidant defense. Thiol-disulfide homeostasis have been implicated in numerous diseases. In this comprehensive review we identified the studies that examined the thiol-disulfide homeostasis in psychiatric disorders. Most cases demonstrated alterations in thiol-disulfide homeostasis and in most of them the thiol-disulfide balance tended to change direction to the disulfide side, that is, to the oxidative side. Currently, the fact that N-acetylcysteine, a thiol-containing compound, is of great interest as a new treatment approach in psychiatric disorders and the role of glutathione, the most abundant thiol, in the brain highlights the importance of evaluating the thiol-disulfide balance in psychiatric disorders.eninfo:eu-repo/semantics/closedAccessAntioxidantsNeuroinflammationOxidative stressPsychiatric disordersThiol-disulfide homeostasisReview Article12310.1016/j.pnpbp.2023.110719Q1WOS:0009949524000012-s2.0-8514745726136634809