Nickel Chloride Hexahydrate Catalyzed Multicomponent Biginelli's Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones

Gulten, Sirin2025-01-272025-01-2720170022-152X1943-5193https://doi.org/10.1002/jhet.2700https://hdl.handle.net/20.500.12428/25130An efficient protocol is reported for the one-pot three-component Bignelli synthesis of a series of 3,4-dihydropyrimidine-2(1H)-ones and thiones in good yields (66-90%) from the aldehydes (4-benzyloxybenzaldehyde, 5-bromovanilin, 4-formyl-1-cyclohexene, and trans-cinnamaldehyde), -keto esters (ethyl acetoacetate, allyl acetoacetate, and t-butyl acetoacetate), and urea/thiourea in ethanol, using nickel chloride hexahydrate as a catalyst.eninfo:eu-repo/semantics/closedAccessOne-Pot SynthesisSolvent-Free ConditionsSolid-Phase SynthesisEfficient SynthesisMagnesium BromideCondensation Reaction3-ComponentDihydropyrimidinonesTetrahydropyrimidinesNickel Chloride Hexahydrate Catalyzed Multicomponent Biginelli's Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and ThionesArticle5421252126010.1002/jhet.2700Q3WOS:0003975630000522-s2.0-84978199983Q2