Yılmaz, Aynur S.Şahiner, Nurettin2025-01-272025-01-2720240021-89951097-4628https://doi.org/10.1002/app.54822https://hdl.handle.net/20.500.12428/22506Cyclodextrins (CDs) are truncated cone-like structures that are natural cyclic oligosaccharides. Here, a simple preparation method for super porous poly(alpha-CD), poly(beta-CD), and poly(gamma-CD) cryogels crosslinking with divinyl sulfone at 150%, 100% and 125% mole ratios with respect to the alpha-CD, beta-CD, and gamma-CD molecules, respectively, under cryogenic conditions, is reported. The interconnected homogeneous pore distribution of CD-based cryogels with pore sizes in the range of 5-100 mu m is confirmed by SEM analysis. The CD-based cryogels weighing 10 mg are determined as hemocompatible with <1% hemolysis ratios and >79% blood clotting indexes; whereas the same materials weighing 1 mg are biocompatible with >75% cell viability on L929 fibroblasts. Additionally, active agent adsorption/delivery efficiencies of CD-based cryogels utilizing two active agents, Bisphenol A (BPA, a carcinogenic compound) and Curcumin (CUR, a polyphenolic compound), are individually evaluated. It was revealed that p(gamma-CD) cryogels exhibited the highest active agent loading capacity for BPA, 87 +/- 13 mg/g, whereas p(alpha-CD) cryogels showed the highest loading capacity for CUR, 136 +/- 4 mg/g. Moreover, the active agent release from p(alpha-CD), p(beta-CD), and p(gamma-CD) cryogel networks at pH 7.4 and 37(degrees)C were determined as 40.6 +/- 2, 35.3 +/- 2, and 34 +/- 1 mg/g for BPA, and 1.07 +/- 0.2, 1.27 +/- 0.1, and 1.37 +/- 0.1 mg/g for CUR, respectively, within 96 h.eninfo:eu-repo/semantics/closedAccessBisphenol Acontrollable active agent releasecryogelcurcumincyclodextrinssuper porous cyclodextrin networkArticle141310.1002/app.54822Q2WOS:0010894881000012-s2.0-85174620666Q2