Topaloglu, NaciKucuk, AdemYildirim, SuleTekin, MustafaErdem, HavvaDeniz, Mustafa2025-01-272025-01-2720152095-02172095-0225https://doi.org/10.1007/s11684-015-0403-1https://hdl.handle.net/20.500.12428/24537Glucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 mu g GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P < 0.001), whereas GLP-2 pretreatment significantly decreased their levels (P < 0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.eninfo:eu-repo/semantics/closedAccessischemia/reperfusionliverglucagon-like peptide-2alanine aminotransferaseArticle9336837310.1007/s11684-015-0403-1Q3WOS:0003684452000122-s2.0-8497341383026290282Q1