Şahiner, MehtapTian, ZhiDemirci, ŞahinSunol, AydınAllen-Gipson, Diane S.Şahiner, Nurettin2025-01-272025-01-2720241612-18721612-1880https://doi.org/10.1002/cbdv.202401857https://hdl.handle.net/20.500.12428/24586Here, using natural hematoxylin (HT) as linker, metal-organic frameworks (MOFs) from Cu(II), Fe(II), and Fe(III) ions was prepared. The SEM images and DLS analyses revealed HT-based MOFs are <micrometer sizes with the highest surface area value of 49.2 m2/g for HT−Fe(III) MOFs. Interestingly, HT-based MOFs exhibit fluorescent properties at λem=330 nm with fluorescence intensities of 11485, 2120, and 6790 (a.u) for HT−Cu(II), Fe(II), and Fe(III) MOFs, respectively. Moreover, HT-based MOFs inhibited α-glucosidase enyzme in a concentration-dependent manner e. g., 33.1 %, 69.8 %, and 59.7 % of Cenzyme=500 mg/mL was inhibited by HT−Cu(II)-MOF, HT−Fe(II)-MOF, and HT−Fe(III)-MOFs, respectively. The minimum bactericidal concentration (MBC) values of HT−Cu(II) MOFs for Escherichia coli (gram −), Staphylococcus aureus (gram +), and Candida albicans are determined as 5, 5, and 10 mg/mL, respectively. Also, the antioxidant activities of 250 ppm HT-based MOF based on total phenol content (TPC) tests revealed 279, 208, 124, and 152 mg.gallic acid equivalent/mL (mg GA equivalency/mL) for HT, HT−Cu(II) MOF, HT−Fe(II) MOF, and HT−Fe(III), respectively affirming that antioxidant properties were retained. Moreover, HT−Fe(II) and HT−Fe(III) MOFs (62.5 μg/mL) against human null-1 lung cell line revealed cell viabilities of 98.7±12.2 % and 88.9±11.7 %, respectively as concentration-dependent biocompatibility of MOFs.eninfo:eu-repo/semantics/closedAccessPhenolic Metal-Organic FrameworksHematoxylinAntimicrobial/antioxidant MOFsBiocompatible MOFsAlpha-glucosidase inhibitorsArticle10.1002/cbdv.202401857N/AWOS:0013573145000012-s2.0-8520820247339327818Q3