Cinpolat, Havva YaseminAlkan, SevilAltinisik, Hatice BetulCakir, Dilek UlkerOguzman, Hamdi2025-01-272025-01-2720230007-5027https://doi.org/10.1093/labmed/lmad009https://hdl.handle.net/20.500.12428/12820Objective: In this study, we aimed to evaluate the serum creatinine (SCr) levels with the reference change value (RCV) in patients receiving colistin treatment. Methods: We retrospectively recorded the SCr levels of 47 patients receiving colistin treatment before treatment and on days 3 and 7 after treatment. RCV was calculated with the asymmetrical RCV formula (Z = 1.64, P <. 05). Percent (%) increase in the SCr results of the patients was compared with RCV and values exceeding RCV were regarded as statistically significant. Results: The RCV was calculated as 15.6% for SCr. Compared with pretreatment values, SCr value on day 3 was 32/47 and on day 7 it was 36/47; as these results exceeded RCV, they were considered statistically significant. Conclusion: Use of RCV in the interpretation of results between serial measurements will provide a more rapid and sensitive method when making decisions. © 2023 The Author(s).eninfo:eu-repo/semantics/openAccessadverse effects; biological variation; clinical chemistry; colistin; reference values; toxicityArticle54658258610.1093/labmed/lmad0092-s2.0-8517650925436883236Q3