Güngör, Tuğba2023-03-272023-03-272021Güngör, T. (2021). Microwave assisted, sequential two-step, one-pot synthesis of novel imidazo[1,2-a] pyrimidine containing tri/tetrasubstituted imidazole derivatives. Turkish Journal of Chemistry, 45(1), 219-230. doi:10.3906/kim-2009-401300-0527https://hdl.handle.net/20.500.12428/3834A series of novel imidazo[1,2-a]pyrimidine containing tri/tetrasubstituted imidazole derivatives (1-10) has been synthesized via sequential two-step, one-pot, multicomponent reaction using imidazo[1,2-a]pyrimidine-2-carbaldehyde, benzil, primary amines, and ammonium acetate catalyzed by p-toluenesulfonic acid under microwave-assisted conditions. The results showed that target compounds can be obtained from a wide range of primary amines bearing different functional groups with moderate to good yields (46%-80%) under optimum reaction conditions. This method provides a green protocol for imidazo[1,2-a]pyrimidine containing tri/ tetrasubstituted imidazole derivatives due to ethyl alcohol as a green solvent, microwave irradiation as a greener heating method and one-pot multicomponent reaction as a green technique. The synthesized compounds have been elucidated using various spectroscopic tools such as FT-IR, 1 H NMR, 13C NMR, and MS.eninfo:eu-repo/semantics/openAccessAttribution 3.0 United StatesImidazo[1,2-a]pyrimidineTri/tetrasubstituted imidazoleMicrowave synthesisSequentialOne-pot reactionP-toluenesulfonic acidArticle45121923010.3906/kim-2009-40Q4WOS:0006392386000212-s2.0-8510231359052599733679165