Misilli, TuğbaUslu, GülşahOrhan, KaanBayrakdar, İbrahim ŞevkiErdönmez, DemetÖzyürek, Taha2025-01-272025-01-2720231677-3217https://doi.org/10.20396/BJOS.V22I00.8671303https://hdl.handle.net/20.500.12428/13085Aim: To evaluate the potential of inducing mineral density changes of indirect pulp capping materials applied to demineralized dentin. Methods: A total of 50 cavities were prepared, 5 in each tooth, in extracted ten molars without caries, impacted or semi-embedded. The cavities were scanned by microcomputed tomography (?-CT) after creating artificial caries by microcosm method (pre-treatment). Each cavity was subjected to one of 5 different experimental conditions: control (dental wax), conventional glass ionomer cement (Fuji IX GP Extra), resin-modified calcium silicate (TheraCal LC), resin-modified calcium hydroxide (Ultra-Blend Plus), MTA (MM-MTA) and the samples were kept under intrapulpal pressure using simulated body fluid for 45 days. Then, the second ?-CT scan was performed (post-treatment), and the change in dentin mineral density was calculated. Afterward, elemental mapping was performed on the dentinal surfaces adjacent to the pulp capping agents of 5 randomly selected samples using energy dispersive X-ray spectroscopy (EDS) apparatus attached to a scanning electron microscope (SEM). The Ca/P ratio by weight was calculated. Friedman test and Wilcoxon Signed Ranks test were used to analyze the data. Results: There was a significant increase in mineral density values of demineralized dentin after treatment for all material groups (p<0.05). Resin-modified calcium silicate had similar efficacy to MTA and conventional glass ionomer cement, but was superior to resin-modified calcium hydroxide in increasing the mineral density values of demineralized dentin. Conclusions: Demineralized dentin tissue that is still repairable can be effectively preserved using materials with remineralization capability. © 2023, Piracicaba Dental School - UNICAMP. All Rights Reserved.eninfo:eu-repo/semantics/openAccessCalcium compounds; Calcium hydroxide; Glass ionomer cement; Silicates; Spectrometry; X-ray emission; X-ray microtomographyArticle2210.20396/BJOS.V22I00.86713032-s2.0-85167885080Q4