Yildiz, Safiye NurSezgin Arslan, TugbaArslan, Yavuz Emre2025-01-272025-01-2720241748-6041https://doi.org/10.1088/1748-605X/ad2557https://hdl.handle.net/20.500.12428/12816Therapeutic angiogenesis is pivotal in creating effective tissue-engineered constructs that deliver nutrients and oxygen to surrounding cells. Hence, biomaterials that promote angiogenesis can enhance the efficacy of various medical treatments, encompassing tissue engineering, wound healing, and drug delivery systems. Considering these, we propose a rapid method for producing composite silicon-boron-wool keratin/jellyfish collagen (Si-B-WK/JFC) inorganic-organic biohybrid films using sol-gel reactions. In this approach, reactive tetraethyl orthosilicate and boric acid (pKa ? 9.24) were used as silicon and boron sources, respectively, and a solid-state gel was formed through the condensation reaction of these reactive groups with the keratin/collagen mixture. Once the resulting gel was thoroughly suspended in water, the films were prepared by a casting/solvent evaporation methodology. The fabricated hybrid films were characterized structurally and mechanically. In addition, angiogenic characteristics were determined by the in ovo chick chorioallantoic membrane assay, which revealed an increased vascular network within the Si-B-WK/JFC biohybrid films. In conclusion, it is believed that Si-B-WK/JFC biohybrid films with mechanical and pro-angiogenic properties have the potential to be possessed in soft tissue engineering applications, especially wound healing. © 2024 The Author(s). Published by IOP Publishing Ltd.eninfo:eu-repo/semantics/openAccessboron; CAM assay; jellyfish collagen; organic-inorganic biohybrid; regenerative medicine; sol-gel; wool keratinArticle19210.1088/1748-605X/ad25572-s2.0-8518500669238306684Q2