Two salonitenolide derivatives from the aerial parts of Centaurea gigantea inhibit the growth of colorectal cancer cells in vitro

Shoeb, MohammadCelik, SezginNahar, LutfunMacManus, Stephen M.Kong-Thu-lin, PaulJaspars, MarcelSarker, Satyajit D.2025-01-272025-01-2720071934-578Xhttps://hdl.handle.net/20.500.12428/24733The cytotoxic activity of two salonitenolide derivatives, 8-O-(3-hydroxy-2-methylpropanoyl)-salonitenolide (or arctiopicrin, 1) and 8-O-(4-hydroxy-3-methylbutanoyl)-salonitenolide,(2), isolated and identified from the methanol extract of the aerial parts of Centaurea gigantea, was assessed by the MTT cytotoxicity assay using the colon cancer cell line, CaCo-2. The IC50 values for 1 and 2 were found to be 8.5 and 26.4 mu M, respectively.eninfo:eu-repo/semantics/closedAccessCentaurea giganteaasteraceae8-O-(3-hydroxy-2-methylpropanoyl)-salonitenolide8-O-(4-hydroxy-3methylbutanoyl)-salonitenolideDPPH assaybrine shrimp lethality assaycolon cancerMTTTwo salonitenolide derivatives from the aerial parts of Centaurea gigantea inhibit the growth of colorectal cancer cells in vitroArticle22121125Q4WOS:0002490073000022-s2.0-68049085850Q2