Can, MehmetDemirci, ŞahinYıldırım, YıldızÇakır Çoban, CananTürk, MustafaŞahiner, Nurettin2025-02-102025-02-102021Can, M., Demirci, S., Yıldrım, Y., Çoban, C. Ç., Türk, M., & Şahiner, N. (2021). Modification of halloysite clay nanotubes with various alkyl halides, and their characterization, blood compatibility, biocompatibility, and genotoxicity. Materials Chemistry and Physics, 259, 124013. https://doi.org/10.1016/j.matchemphys.2020.1240130254-0584 / 1879-3312https://doi.org/10.1016/j.matchemphys.2020.124013https://hdl.handle.net/20.500.12428/29608Halloysite nanotubes (HNTs) clay were modified with alkyl halides, bromoethane (BrE), bromodecane (BrD), and bromooctadecane (BrOD), respectively. The FT-IR spectra of modified HNTs demonstrated an increase in the intensity of aliphatic –CH2 peaks at 2920 and 2850 cm−1 proportional to the number of C atoms in the modifying agent confirming the success of chemical modification with corresponding alkyl halides. Surface charge of NaOH treated HNTs, −65.7 ± 5.1 mV was increased to −37.1 ± 2.4, −40.6 ± 5.3, and −44.7 ± 1.9 mV, respectively upon chemical modification with BrE, BrD, and BrOD. The Surface area of the HNT clays, 43.2 ± 1.3 m2/g was also increased to 59.8 ± 2.7, 56.9 ± 2.1, and 47.9 ± 1.7 m2/g for BrE, BrD, and BrOD modified HNT clays, respectively. Base-activated HNT clays at 1 mg/mL concentration found to be nonhemolytic with 3.5 ± 1.2% hemolysis ratio, whereas HNT-BrOD clays were slightly exceeded hemolytic safety level with 6.6 ± 0.2% hemolysis induction. Base-activated HNT and HNT-BrOD clays were found to show antithrombogenic character with more than 100% blood clotting indexes,107.6 ± 1.8, and 106.5 ± 1.9%, respectively. Cytotoxicity studies of HNTs on L929 fibroblast cells revealed that HNTs in 12.5–200 μg/mL concentration range were shown dose-dependent cell viability, and above 50% cell viability was maintained at 200 μg/mL in all forms of HNT based clays administered.enginfo:eu-repo/semantics/closedAccessBiocompatible HNTBlood compatible HNTGenotoxicityNatural halloysite nanoclaySurface modified HNTarticle25910.1016/j.matchemphys.2020.124013Q2WOS:0006157292000052-s2.0-85096686054Q1