Hacivelioglu, S.Uysal, A.Gungor, A. N. CakirGencer, M.Cakir, D. U.Cosar, E.2025-01-272025-01-2720150390-6663https://hdl.handle.net/20.500.12428/25338Objective: To evaluate the effect of maternal polycystic ovary (PCO) morphology on maternal serum free beta-human chorionic gonadotropin (beta-hCG), pregnancy associated plasma protein A (PAPP-A), and nuchal translucency (NT) thickness in the first-trimester. Material and Methods: A total of 92 pregnant women in the first-trimester were included in the study. Of them, 57 had PCO morphology, and 35 women constituted the control group, with apparently normal ovaries. Maternal serum free beta-hCG, PAPP-A, and NT thickness were measured and compared in all patients. Results: The multiples of median (MoM) levels of serum free beta-hCG were significantly higher in the PCO morphology group compared to the normal ovary group (p = 0.024). However, the MoM levels of PAPP-A were similar in both groups (p = 0.947). No difference was found between the groups in terms of fasting glucose levels and NT measurements (p = 0.976 and 0.565, respectively). Conclusion: In pregnancies with maternal PCO morphology, the presence of higher maternal serum free beta-hCG levels may require correction in the calculation of risks related to first-trimester screening for chromosomal abnormalities. Larger studies are needed to confirm our preliminary data.eninfo:eu-repo/semantics/closedAccessMaternal serum screening testNuchal translucency measurementPolycystic ovary syndromePregnancy-associated plasma protein-AArticle4213235Q4WOS:0003511914000062-s2.0-8492454896625864278Q4