Ersan, IsmailKilic, SevilayArikan, SedatKara, SelcukIsik, SeldaGencer, BaranOgretmen, Zerrin2025-01-272025-01-2720170927-39481744-5078https://doi.org/10.3109/09273948.2016.1150493https://hdl.handle.net/20.500.12428/27286Purpose: To evaluate changes in the thickness of the central macula, macular ganglion cell-inner plexiform layer (mGCIPL), and subfoveal choroid in patients with psoriasis using spectral domain optical coherence tomography (SD-OCT). Methods: The measurements of macular, mGCIPL thicknesses and subfoveal choroidal thickness (SFCT) obtained by SD-OCT of psoriasis patients (n = 46). These measurements were compared with those of 50 healthy controls. Results: The macular, mGCIPL, and choroidal thicknesses did not differ between the controls and psoriatic subjects (p>0.05). When the patients were divided into two distinct groups, only the SFCT was significantly thicker in the severe psoriasis group compared with the mild psoriasis group (p = 0.003). Conclusions: These findings suggest that choroidal alterations are seen without macular changes in patients with psoriasis. Severe psoriasis appears to be related to increases in SFCT as a consequence of possible inflammatory cascades that are part of the disease's pathogenesis.eninfo:eu-repo/semantics/closedAccessChoroidal thickeningmacular ganglion cell layerpsoriasis area and severity indexsystemic inflammationtumor necrosis factor alphaArticle25452052410.3109/09273948.2016.1150493Q1WOS:0004127909000112-s2.0-8496165803527015161Q1